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btrK

Gene
btrK
Protein
L-glutamyl-[BtrI acyl-carrier protein] decarboxylase
Organism
Bacillus circulans
Length
428 amino acids
Function
Pyridoxal phosphate-dependent decarboxylase that catalyzes 1 step in the biosynthesis of the side chain of the aminoglycoside antibiotics in the biosynthetic pathway of butirosin. Able to decarboxylate L-ornithine, L-arginine, L-lysine, but not L-glutamate or any D-amino acids. Has low activity with substrates not bound to an acyl-carrier protein.
Similarity
Belongs to the Orn/Lys/Arg decarboxylase class-II family.
Mass
47.816 kDa
Sequence
MNLDQAEITALTKRFETPFYLYDGDFIEAHYRQLRSRTNPAIQFYLSLKANNNIHLAKLFRQWGLGVEVASAGELALARHAGFSAENIIFSGPGKKRSELEIAVQSGIYCIIAESVEELFYIEELAEKENKTARVAIRINPDKSFGSTAIKMGGVPRQFGMDESMLDAVMDAVRSLQFTKFIGIHVYTGTQNLNTDSIIESMKYTVDLGRNIYERYGIVCECINLGGGFGVPYFSHEKALDIGKITRTVSDYVQEARDTRFPQTTFIIESGRYLLAQAAVYVTEVLYRKASKGEVFVIVDGGMHHHAASTFRGRSMRSNYPMEYIPVREDSGRRELEKVTIAGPLCTPEDCLGKDVHVPALYPGDLVCVLNSGAYGLSFSPVHFLGHPTPIEILKRNGSYELIRRKGTADDIVATQLQTESNLLFVDK