btbd6a

BTB/POZ domain-containing protein 6-A

540 amino acids

Adapter protein for the cul3 E3 ubiquitin-protein ligase complex. Promotes the export of zbtb16/plzf from the nucleus to the cytoplasm and targets zbtb16/plzf for ubiquitination and degradation. Up-regulates neurog1 expression and antagonizes zbtb16/plzf, to promote neurogenesis.

59.805 kDa

MPAAPECRLSNHGRIMKCVTFLLLLPETLKKLKRASKHPGRLSVCYNILTLSLKKRMAAELYPVSDHATLQKSGAVMLSLPEKKRNVEPVSQTTASIATTPTTEQNINNNNVEIPSWHSAHPTLRERNALMFNNEQMADVHFIVGPPGESQRVPAHKYVLAVGSSVFCAMFYGDLAEGDSDIHIPDVEPAAFLILLKYMYSDEIELAPDTVLATLYAAKKYLVSALARACVGFLETSLEARNACVLLSQSRLFEEPELTQRCWEVIDAQAELALRSEGFSEIDLPTLESILHRETLNVKESVVFQAVLGWADAECRRQGLSPTSQNQRSVLGKALHLVRLPSMTLQEFADGAAQVDILTLEETHSIFLWYTAATKPSLGFPVNAREGLTAQRCHRFQSSAYRSNQWRYRGRCDSIQFAVDKRVFIAGLGLYGSSGGKAEYSVRIELKRQGVLLAQNLTKFVSDGSSSTFPVWFEHPVQVEQDAFYTVSAVLDGSELSYFGQEGMTEVQCGKVTFQFQCSSDSTNGTGVQGGQIPELIFYA