Protein
Modification methylase BspRI
Organism
Lysinibacillus sphaericus
Function
This methylase recognizes the double-stranded sequence GGCC, causes specific methylation on C-3 on both strands, and protects the DNA from cleavage by the BspRI endonuclease.
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
Sequence
MAIKINEKGRGKFKPAPTYEKEEVRQLLMEKINEEMEAVATATSDISNDEIQYKSDKFNVLSLFCGAGGLDLGFELAGLEQSLGTDKALEAFKDRDVYNAIRHESVFHTVYANDIFSEALQTYEKNMPNHVFIHEKDIRKIKEFPSANLVIGGFPCPGFSEAGPRLVDDERNFLYIHFIRCLMQVQPEIFVAENVKGMMTLGGGEVFRQIVEDFGAAGYRVEARLLNARDYGVPQIRERVIIVGVRNDIDFNYEYPEITHGNEEGLKPYVTLEEAIGDLSLDPGPYFTGSYSTIFMSRNRKKKWTDQSFTIQASGRQAPIHPGGLPMEKVDKNKWIFPDGEENHRRLSVKEIKRIQTFPDWYEFSDGGNMKVSVNNRLDKQYKQIGNAVPVFLARAVAKSIAQFAADYLKDNHPHEAPQMKLFI