Protein
N(4)-bis(aminopropyl)spermidine synthase
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Function
Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.
Similarity
Belongs to the branched-chain polyamine synthase family.
Sequence
MERILEKVRAKSEIPVYDKSIENVLSAILTTNDFWKIVDLSEEPLPLVADIIRILEEEGLVKISNGIEFTEKGNEFIKSYGIGAKDNSVCECCEGRGVSLKNYQDLLERFKEIVKNRPMPKHEYDQGFVTPECTISRIALMNSRGDLFNKDVLVLGDDDLTSIALMLSNLPKKIVVVDIDDRLINFIKEVAEQLNYKNIEVITLDLRKPLPEKYSRAFDTFITDPPETVYAVKTFIGRGISALKGERRAGYFGITRRESSLDKWREIQRTLINDFNVVITDIIRNFNHYVNWGYEEETRAWKLAPVKKKPEDIWYKSYMFRIETLKDSRGFEEEVDVGDELYNDAESSTT