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bmt2

Gene
BMT2
Protein
Beta-mannosyltransferase 2
Organism
Komagataella phaffii (strain GS115 / ATCC 20864)
Length
644 amino acids
Function
Beta-mannosyltransferase involved in cell wall biosynthesis. Initiates the beta-mannosylation of core N-linked glycans.
Similarity
Belongs to the BMT family.
Mass
74.561 kDa
Sequence
MRTRLNFLLLCIASVLSVIWIGVLLTWNDNNLGGISLNGGKDSAYDDLLSLGSFNDMEVDSYVTNIYDNAPVLGCTDLSYHGLLKVTPKHDLACDLEFIRAQILDIDVYSAIKDLEDKALTVKQKVEKHWFTFYGSSVFLPEHDVHYLVRRVIFSAEGKANSPVTSIIVAQIYDKNWNELNGHFLDILNPNTGKVQHNTFPQVLPIATNFVKGKKFRGAEDPRVVLRKGRFGPDPLVMFNSLTQDNKRRRIFTISPFDQFKTVMYDIKDYEMPRYEKNWVPFFLKDNQEAVHFVYSFNPLRVLKCSLDDGSCDIVFEIPKVDSMSSELRGATPMINLPQAIPMAKDKEIWVSFPRTRIANCGCSRTTYRPMLMLFVREGSNFFVELLSTSLDFGLEVLPYSGNGLPCSADHSVLIPNSIDNWEVVDSNGDDILTLSFSEADKSTSVIHIRGLYNYLSELDGYQGPEAEDEHNFQRILSDLHFDNKTTVNNFIKVQSCALDAAKGYCKEYGLTRGEAERRRRVAEERKKKEKEEEEKKKKKEKEEEEKKRIEEEKKKIEEKERKEKEKEEAERKKLQEMKKKLEEITEKLEKGQRNKEIDPKEKQREEEERKERVRKIAEKQRKEAEKKEAEKKANDKKDLKIRQ

Gene
BMT2
Protein
Beta-mannosyltransferase 2
Organism
Komagataella phaffii (strain ATCC 76273 / CBS 7435 / CECT 11047 / NRRL Y-11430 / Wegner 21-1)
Length
635 amino acids
Function
Beta-mannosyltransferase involved in cell wall biosynthesis. Initiates the beta-mannosylation of core N-linked glycans (By similarity).
Similarity
Belongs to the BMT family.
Mass
73.436 kDa
Sequence
MRTRLNFLLLCIASVLSVIWIGVLLTWNDNNLGGISLNGGKDSAYDDLLSLGSFNDMEVDSYVTNIYDNAPVLGCTDLSYHGLLKVTPKHDLACDLEFIRAQILDIDVYSAIKDLEDKALTVKQKVEKHWFTFYGSSVFLPEHDVHYLVRRVIFSAEGKANSPVTSIIVAQIYDKNWNELNGHFLDILNPNTGKVQHNTFPQVLPIATNFVKGKKFRGAEDPRVVLRKGRFGPDPLVMFNSLTQDNKRRRIFTISPFDQFKTVMYDIKDYEMPRYEKNWVPFFLKDNQEAVHFVYSFNPLRVLKCSLDDGSCDIVFEIPKVDSMSSELRGATPMINLPQAIPMAKDKEIWVSFPRTRIANCGCSRTTYRPMLMLFVREGSNFFVELLSTSLDFGLEVLPYSGNGLPCSADHSVLIPNSIDNWEVVDSNGDDILTLSFSEADKSTSVIHIRGLYNYLSELDGYQGPEAEDEHNFQRILSDLHFDNKTTVNNFIKVQSCALDAAKGYCKEYGLTRGEAERRRRVAEERKKKEKEEEEKKKKKEKEEEEKKRIEEEKKKIEEKERKEKEKEEAERKKLQEMKKKLEEITEKLEKGQRNKEIDPKEKQREEEERKERVRKIAEKQRKEAEKKEAEKKGK

Gene
BMT2
Protein
S-adenosylmethionine sensor upstream of mTORC1
Organism
Gallus gallus
Length
408 amino acids
Function
S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.
Similarity
Belongs to the BMT2 family.
Mass
46.514 kDa
Sequence
MEAAPRSRPRPGGAAASPPPPPPPPPPEQERKLEQEKLSGVVKSVHRRLRKKYREVGDFDKIWREHCEDEETLCEYAVAMKNLADNHWAKTCEGEGRIEWCCSVCREYFQNGGKRKALEKDEKRALLASKSTPALNASQPPKIEDPLPNFGLTNHEAITEELLHSLGKIRLLDVGSCFNPFLKFEEFLTVGIDIVPAVESVYKCDFLNLQIQQPLQLAQDAIDAFLKQLKNPIDSLPGELFHVVVFSLLLSYFPSPYQRWICCKKAHELLVLNGLLLVITPDSSHQNRRAMMMKSWKIAIESLGFKRFKYSKFSHMHLMAFRKTSLQTTSDLVSRNYPGMLYIPQDFNSIEDEEYSNTSCYIRSDMEDEQLAYGFMELPDAPYDSDSGESQSSSIPFYELEDPVLLLS

Gene
BMT2
Protein
S-adenosylmethionine sensor upstream of mTORC1
Organism
Homo sapiens
Length
405 amino acids
Function
S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes (PubMed:29123071). Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling (PubMed:29123071). Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling (PubMed:29123071). Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase (Potential).
Similarity
Belongs to the BMT2 family.
Mass
46.324 kDa
Sequence
MEPGAGGRNTARAQRAGSPNTPPPREQERKLEQEKLSGVVKSVHRRLRKKYREVGDFDKIWREHCEDEETLCEYAVAMKNLADNHWAKTCEGEGRIEWCCSVCREYFQNGGKRKALEKDEKRAVLATKTTPALNMHESSQLEGHLTNLSFTNPEFITELLQASGKIRLLDVGSCFNPFLKFEEFLTVGIDIVPAVESVYKCDFLNLQLQQPLQLAQDAIDAFLKQLKNPIDSLPGELFHVVVFSLLLSYFPSPYQRWICCKKAHELLVLNGLLLIITPDSSHQNRHAMMMKSWKIAIESLGFKRFKYSKFSHMHLMAFRKISLKTTSDLVSRNYPGMLYIPQDFNSIEDEEYSNPSCYVRSDIEDEQLAYGFTELPDAPYDSDSGESQASSIPFYELEDPILLLS

Gene
Bmt2
Protein
S-adenosylmethionine sensor upstream of mTORC1
Organism
Mus musculus
Length
403 amino acids
Function
S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.
Similarity
Belongs to the BMT2 family.
Mass
45.952 kDa
Sequence
MEPGPGGRGAARGQRPPNAAQPREQERKLEQEKLSGVVKSVHRRLRKKYREVGDFDKIWREHCEDAETLCEYAVAMKNLADNHWAKTCEGEGRIEWCCSVCREYFQNGGKRKALEKDEKRAVLATKTTPALNVHESSKLEGPLTNLSFTSPDFITELLQASGKIRLLDVGSCFNPFLKFEEFLTVGIDIVPAVESVYKCDFLNLQLQQPLQLAQDAIDAFLKQLRNPIDALPGELFHVVVFSLLLSYFPSPYQRWICCKKAHELLVLNGLLLIITPDSSHQNRHAMMMKSWKIAIESLGFKRFKYSKFSHMHLMAFRKTSLKTTSDLVSRNYPGMLYIPQDFNSVEEEEYSNTSCYVRSDLEDEQLAYGFTELPEAPYDSDSGESQASSIPFYELEDPILLLS

Gene
bmt2
Protein
S-adenosylmethionine sensor upstream of mTORC1
Organism
Xenopus laevis
Length
400 amino acids
Function
S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.
Similarity
Belongs to the BMT2 family.
Mass
45.75 kDa
Sequence
MEAVLPSRCNREDVPGKARAERFVSGFPSVCEQKTEQEKLSGVVKRVHLDLRKKYRKAGDFEKIWLEHCKDDGRLCEYAVAMKALADNHWAKKCEGEGRIEWCLGVCQEYFFNGGKKKALEKDAKRDALNKLQSSSHAEAGVSDFGVPSIKPLNDEYMTGKIRLLDVGSCYNPFLKYEDFLAVGIDIVPAVETVFKCDFLNLQIQRPLQLAPDAIDAFLKQLSSPIDYLPTELFHVIVFSLLLSYFPSPYQRWICCKKAHELLTLNGLLLIITPDSSHQNRHAVMMKSWKIAIESLGFRRMTYSKFSHMHLMAFRKTSLKTTSDLLTRNYPDMLYIPQDFNYDGEEDHFSPCCARSELEDEQLACGFTELPDTPYDSDSGESHNSTMPFYEFEDPILLLT

Gene
bmt2
Protein
S-adenosylmethionine sensor upstream of mTORC1
Organism
Xenopus tropicalis
Length
400 amino acids
Function
S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.
Similarity
Belongs to the BMT2 family.
Mass
45.958 kDa
Sequence
MEPVLQARGKRENVLGNAREERCVPGFPSACEQKLEQEKLSGVVKRVHRDLRKKYREAGDFEKIWLEHCKDKGRLCEYAVAMKALADNHWAKKCEGEGRIEWCLGVCQEYFFNGGKKKAIEKDARRATLNKLQSPNHAEDGVSDFSVPNIKPLNDEYMTGKIRLLDVGSCYNPFLKYEDFLAVGIDIVPAVETVCKCDFLNLQIQRPLQFAPDAIDAFLKQLESPIDYLPAELFHVVVFSLLLSYFPSPYQRWICCKKAHELLTLNGLLLIITPDSSHQNRHAVMMKSWKIAIESLGFRRMTYSKFSHMHLMAFRKTSLKTTSDLITMNYPDMLYIPQDFNYDGEEDYFSPCCARSELEDEQLACGFTELPDTPYDSDSGESQNSTMPFYEFEDPILLLT

Gene
bmt2
Protein
S-adenosylmethionine sensor upstream of mTORC1
Organism
Danio rerio
Length
393 amino acids
Function
S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.
Similarity
Belongs to the BMT2 family.
Mass
44.782 kDa
Sequence
MDLRSSAETDPDLSENHPGSVPAELQSRKQEQEKLSGVVKSVHRKLRRKYIEVGDFDKIWREHCEDEQTLSEYAMAMKNLADNHWANKCEGEGRIEWCRSVCQEYFQDGGMRRVLEKDEKSARHATAGNANTDTNAPPQLSSISTSSTFQLGKIRLLDVGSCFNPFLKFDEFLTVGIDIVPAVESVYKCDFLNLQLQQPLQLASDALDAFLRQLRGPIDALPAELFHVVVFSLLLSYFPSPYQRWLCCKKAHELLTLNGLLLIITPDSSHQGRHALMMRSWRVAVESLGFKRYKYVKFSHMHLIAFRKVSPTTSSDLVSRNYPEMLYIPQDFNTFDEDGFADCYEPPRSDFEDDQMACSFAELPETPYDSDSGESQSSSAPFYELEDPILLQS

Gene
BMT2
Protein
25S rRNA (adenine(2142)-N(1))-methyltransferase
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
337 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine 2142 in 25S rRNA. N(1)-methyladenine(2142) in 25S rRNA is present in helix 65, a region that accounts for most of the intersubunit surface of the large subunit.
Similarity
Belongs to the BMT2 family.
Mass
38.55 kDa
Sequence
MHSRKSKSITGKRKQVGSNVTRVIKPQKTRRIIRRFHHLINKRQSICKFLCLKENLDDSNEEKNDKIIRLSIKGNVRLGKYYEDGKSQSFNDAMESQLLRLHSLIKNESKSKDTSDLAVMYTLLGYIMNQINKLGGLETYQIASQNGQLKERGGDTSKLLEKWIRSSFENCPGAVALEIGSLSSGNRISRCALFRNVVRIDLEEHEGVIKQDFMERPLPRNENDKFDLISCSLVLNFVKNHRDRGAMCHRMVKFLKPQGYIFIVLPQACVTHSRYCDKTLLQNLLGSIGLIMLNSHQSNKLYYCLYQLQVVPPQPSSFSKRIKVNDGPGLNNFGITL