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bmi1a

Gene
bmi1a
Protein
Polycomb complex protein BMI-1-A
Organism
Xenopus laevis
Length
326 amino acids
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of rnf2 (By similarity).
Mass
36.945 kDa
Sequence
MHRTTRIKITELNPHLMCVLCGGYFIDATTIIECLHSFCKTCIVRYLETSKYCPICDVQVHKTRPLLNIRADKTLQDIVYKLVPGLFKGEMKRRRDFYAAHPSADVANGSNEDRGEVADEDKRIITDDEIISLSIEFFDQNKADRKGSKDKDKEKSKDEINDKRYLRCPAALTIMHLRKFLRSKMDIPSNFQIDVMYEEEALKDYYTLMDIAYIYTWRRNGPLPLKYRVRPTCKRVKINPHTDRINHTSGDMESDSGSDKAGSLGVVIPSTSSCIPSPPVQSPHPHFPHISSTINGTSSSSSSHQNPFTNRARKISLNGVSAISSG

Gene
bmi1a
Protein
Polycomb complex protein BMI-1-A
Organism
Danio rerio
Length
320 amino acids
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of rnf2.
Mass
36.539 kDa
Sequence
MHRTTRIKITELNPHLMCVLCGGYFIDATTIIECLHSFCKMCIVRYLETSKYCPICDVQVHKTKPLLNIRSDKTLQDIVYKLVPGLFKNEMKRRRDFYAEHPSVDAANGSNEDRGEVADEDKRIITDDEIISLSIEFFDHRAQQQGCTEERQKEEVNNKRYLQCPAAMTVMHLRKFLRSKMDIPPTYQIEVMYEDEPLKDYYTLMDIAYIYTWRRNGPLPLKYRVRPSCKKMKITHPQEGLNNANRSESDSASDKACSPAGVPSTSSPLPSPSTLVQPSQPHFTHISSPINGTTMTSPNRQFNFSKVRKSALNGSSTSSG