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bluB

Gene
bluB
Protein
5,6-dimethylbenzimidazole synthase
Organism
Rhizobium meliloti (strain 1021)
Length
227 amino acids
Function
Involved in the biosynthesis of cobalamin (vitamin B12). Catalyzes the oxidative fragmentation and contraction of the isoalloxazine heterocycle and the cleavage of the ribityl tail of FMN(2) to form 5,6-dimethylbenzimidazole (DMB) and D-erythrose 4-phosphate (E4P). NAD(P)H is only required initially to reduce FMN and oxygen drives the oxidative fragmentation.
Similarity
Belongs to the BluB family.
Mass
25.508 kDa
Sequence
MLPDPNGCLTAAGAFSSDERAAVYRAIETRRDVRDEFLPEPLSEELIARLLGAAHQAPSVGFMQPWNFVLVRQDETREKVWQAFQRANDEAAEMFSGERQAKYRSLKLEGIRKAPLSICVTCDRTRGGAVVLGRTHNPQMDLYSTVCAVQNLWLAARAEGVGVGWVSIFHESEIKAILGIPDHVEIVAWLCLGFVDRLYQEPELAAKGWRQRLPLEDLVFEEGWGVR

Gene
bluB
Protein
5,6-dimethylbenzimidazole synthase
Organism
Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
Length
207 amino acids
Function
Involved in the biosynthesis of cobalamin (vitamin B12). Catalyzes the oxidative fragmentation and contraction of the isoalloxazine heterocycle and the cleavage of the ribityl tail of FMNH(2) to form 5,6-dimethylbenzimidazole (DMB) and D-erythrose 4-phosphate (E4P). NAD(P)H is only required initially to reduce FMN and oxygen drives the oxidative fragmentation (By similarity).
Similarity
Belongs to the BluB family.
Mass
23.059 kDa
Sequence
MNFEQTHRDALTEVLRWRRDVRHFRPDPIDEAVIDRLRAVMDMAPSVGNARPWRVIRVDSPALRAEVLANFNAARAAAGSAYAGEQAEAYATLKLQGIDQAPLQLAVFTHRDPAAGHGLGRASMPVTLQQSTAMAIHTLWLAARAENLGLGMVSVLDPKAVERLLNAPPDWDFVAWLCIGVPEFTDDTPLLHRAGWQENLPTEWERR

Gene
bluB
Protein
5,6-dimethylbenzimidazole synthase
Organism
Rhodobacter capsulatus
Length
206 amino acids
Function
Involved in the biosynthesis of cobalamin (vitamin B12). Catalyzes the oxidative fragmentation and contraction of the isoalloxazine heterocycle and the cleavage of the ribityl tail of FMNH(2) to form 5,6-dimethylbenzimidazole (DMB) and D-erythrose 4-phosphate (E4P). NAD(P)H is only required initially to reduce FMN and oxygen drives the oxidative fragmentation (By similarity).
Similarity
Belongs to the BluB family.
Mass
22.862 kDa
Sequence
MNFEQTHRDALTEVLRWRRDVRHFRPDPIDEAVIDRLRAVMDMAPSVGNARPWRVIRVDSPALRAEVLANFNAARAAAGSAYAGEQAEAYATLKLQGIDQAPLQLAVFTHRDPAAGHGLGRASMPVTLQQSTAMAFTRSGCRAGENLGLGMVSVLDPKAVERLLNAPPDWDFVAWLCIGVPEFTDDTPLLHRAGWQENLPTEWERR