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bla

Gene
bla
Protein
Beta-lactamase FAR-1
Organism
Nocardia farcinica (strain IFM 10152)
Length
313 amino acids
Function
Confers high levels of resistance to amoxicillin, benzylpenicillin, piperacillin, ticarcillin and cephalothin. Also hydrolyzes aztreonam at a low level. Not active against ceftazidime, cefotaxime and imipenem.
Similarity
Belongs to the class-A beta-lactamase family.
Mass
32.566 kDa
Sequence
MPGVDISFLKKSGRRTMAAAAVIALLGGCGADAGSEPATTAASTTAPSAATDAATAEFAALEQRFGARLGVYAVDTTSGAVVAYRADERFGMASTFKGLACGALLREHPLSSGYFDQVVRYSREEVVSYSPVTETRVDTGMTVAELCHATITVSDNTAGNQILKLLGGPAGFTAFLRSLGDEVSRLDRWETELNEVPPGEERDTTTPAAVAANYRALVLGDVLAEPERAQLRDWLVANTTGDQRIRAGVPAGWTVGDKTGGGSHGGNNDVAVAWTETGDPIVIALLSHRTDPAAKADNALLAEATRAVVTALR

Gene
bla
Protein
Beta-lactamase BRO-1
Organism
Moraxella catarrhalis
Length
313 amino acids
Similarity
Belongs to the class-A beta-lactamase family.
Mass
35.383 kDa
Sequence
MQRRHFLQKTLLALPIIFSGNLLTGCKTNLSDDYLPDDKITNNPNLLQNKLKEILPIWENKFNAKIGMTIIADNGELSSHRGNEYFPVNSTIKAFIASHILLLVDKEKLDLNEKIIIKESDLIEYSPVCKKYFDENKPISISELCEATITLSDNGSANILLDKIGGLTAFNQFLKEIGADMVLANNEPLLNRSHYGETSDTAKPIPYTKSLKALIVGNILSNQSKEQLITWLINDKVADNLLRKYLPKNWRIGDKTGTGSESKNIIAVIWNENNKPYFISLFITQPHDGKSLDFKNQKDEIMAQIGKEIYPFL

Gene
bla
Protein
Beta-lactamase
Organism
Streptomyces cellulosae
Length
311 amino acids
Function
Hydrolyzes benzylpenicillin and cloxacillin (at 10% of the rate of benzylpenicillin).
Similarity
Belongs to the class-A beta-lactamase family.
Mass
33.137 kDa
Sequence
MRKPTSSLTRRSVLGAGLGLGGALALGSTTASAASAGTTPSENPAAVRRLRALEREHQARIGVFALNLATGASLLHRAHELFPMCSVFKTLAAAAVLRDLDHDGSQLARVIRYTEADVTKSGHAPVTKDHIDTGMTIRDLCDATIRYSDNCAANLLLRELGGPTAVTRFCRSLGDPVTRLDRWEPELNSGEPDRRTDTTSPYAIARTYQRLVLGNALNRPDRALLTDWLLRNTTTLTTFRTGLPKGWTVADKSGGGDTYGTRNEAAIAWTPDGAPVLLTALTHKPSLPTAPGDTPLIIKLATVLSEAVAPA

Gene
bla
Protein
Beta-lactamase
Organism
Kitasatospora aureofaciens
Length
311 amino acids
Similarity
Belongs to the class-A beta-lactamase family.
Mass
32.486 kDa
Sequence
MRLTQAPPSRRTLMTLGAGATMAALLPAGGAAYASTSTAKAPAAEGISGRLRALEKQYAARLGVFALDTGTGAGRSYRAGERFPMCSVFKALAAAAVLRDVDARREFLTKRIHYTEKFVKDAGYIPVTGKPENIAGGMTGAELCAAAVSESDNGAGNLLLRELDGPTGITRFCRSLGDTTTRLDRWEPALNSAEPDRVTDTTSPGAIGRTFGRLIVGSALRAGDRKRLTGWLVANTTNRPTFRAGLPDDWVLADKTGGGEQYGVANDVGVVQPPGRAPLVLSVLSTKFDPKGPTDNPLVAKAAALVAGELT

Gene
bla
Protein
Beta-lactamase AST-1
Organism
Nocardia asteroides
Length
310 amino acids
Function
Confers high levels of resistance to amoxicillin, benzylpenicillin, piperacillin, ticarcillin and cephalothin. Not active against ceftazidime, cefotaxime and aztreonam.
Similarity
Belongs to the class-A beta-lactamase family.
Mass
32.476 kDa
Sequence
MTFSALPFRRADRRRLLAAALAACALTLTAACDSGTVTVPVTDSVTTSAVADPRFAELETTSGARLGVFAVDTGSGRTVAHRADERFPMASTFKGLACGALLREHPLSTGYFDQVIHYSAAELVEYSPVTETRVETGMTVRELCDAAITVSDNTAGNQLLKLLGGPEGFTASLRSLGDATSRLDRWETDLNTAIPGDERDTTTPAALAADYRALVVGDVLGAPERDQLKAWLVANTTGATRIRAGLPADWTVGDKTGSPAYGSALDVAVAWPPGRAPIVIAVLSTKSEQDAEPDNALLAEATRVVVDALG

Gene
bla
Protein
Beta-lactamase
Organism
Bacillus thuringiensis
Length
309 amino acids
Function
This protein is a beta-lactamase with a substrate specificity for penicillins.
Similarity
Belongs to the class-A beta-lactamase family.
Mass
33.699 kDa
Sequence
MMILKNKRMLKIGICVGILGLSITSLEAFTGGALQVEAKQKTGQVKHKNQATHKEFSQLEKKFDARVGVYAIDTGTNQTISYRSNERFAFASTYKALAAGVLLQQNSIDTLNEVITFTKEDLVDYSPVTEKHVDTGMKLGEIAEAAVRSSDNTAGNILFNKIGGPKGYEKALRKMGDRVTMSDRFETELNEAIPGDIRDTSTAKRIATNLKAFTVGNALPAEKRKILTEWMKGNATGDKLIRAGVPTDWVVGDKSGAGSYGTRNDIAIVWPPNRAPIIIAILSSKDEKEASYDNQLIAEATEVIVKALK

Gene
bla
Protein
Beta-lactamase
Organism
Amycolatopsis lactamdurans
Length
302 amino acids
Function
Active on penicillins but not on cephalosporins.
Similarity
Belongs to the class-A beta-lactamase family.
Mass
32.084 kDa
Sequence
MADRRRVHAWARARPAAPEPAPPTPSAAAPSVAPGPAATPPDPAVEQEFTRLQTQYDARLGLYAVDTGSGESVAFRADERFAFASTFKALAAAAVLDSTTPQQLDQVVRYSKDELLENSPITKDHVATGMTLRELCDAAVRFSDNTAGNLLLKHVGGPQGLDAALTAVGDEVTSADRWEPELNSAVPGDVRDTSTPRALAHDLRQFVLGDALAEDDRALLTDWLRRNTTGGTVIRAGVPADWVVGDKTGSGYYGGRNDIAVLWPPNRAPIVMAVMTSREEPRAKRADALLADAARVAVTALG

Gene
bla
Protein
Carbapenem-hydrolyzing beta-lactamase KPC
Organism
Klebsiella oxytoca
Length
293 amino acids
Function
Hydrolyzes carbapenems, penicillins, cephalosporins and aztreonam with varying efficiency.
Similarity
Belongs to the class-A beta-lactamase family.
Mass
31.115 kDa
Sequence
MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHSEAVIAAAARLALEGLGVNGQ

Gene
bla
Protein
Carbapenem-hydrolyzing beta-lactamase KPC
Organism
Klebsiella pneumoniae
Length
293 amino acids
Function
Hydrolyzes carbapenems, penicillins, cephalosporins and monobactams with varying efficiency.
Similarity
Belongs to the class-A beta-lactamase family.
Mass
31.115 kDa
Sequence
MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHSEAVIAAAARLALEGLGVNGQ

Gene
bla
Protein
Beta-lactamase Toho-1
Organism
Escherichia coli
Length
291 amino acids
Function
Has strong cefotaxime-hydrolyzing activity.
Similarity
Belongs to the class-A beta-lactamase family.
Mass
31.447 kDa
Sequence
MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAERRRDILAAAAKIVTHGF

Gene
bla
Protein
Beta-lactamase CTX-M-1
Organism
Escherichia coli
Length
291 amino acids
Function
Broad spectrum beta-lactamase which confers resistance to penicillins, as well as first, second and third-generation cephalosporins.
Similarity
Belongs to the class-A beta-lactamase family.
Mass
31.246 kDa
Sequence
MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVDGTMSLAELSAAALQYSDNVAMNKLISHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL

Gene
bla
Protein
Beta-lactamase CTX-M-2
Organism
Salmonella typhimurium
Length
291 amino acids
Function
Has cefotaxime-hydrolyzing activity.
Similarity
Belongs to the class-A beta-lactamase family.
Mass
31.378 kDa
Sequence
MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAESRRDILAAAAKIVTHGF

Gene
bla
Protein
Beta-lactamase CTX-M-4
Organism
Salmonella typhimurium
Length
291 amino acids
Function
Has cefotaxime-hydrolyzing activity.
Similarity
Belongs to the class-A beta-lactamase family.
Mass
31.255 kDa
Sequence
MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGVAQINTADNSQILYVADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIRASDLVNYNPIAEKHVNGTMTLAELGAGALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNSAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGMPKSWGVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAESRRDILAAAAKIVTHGF

Gene
bla
Protein
Beta-lactamase CTX-M-5
Organism
Salmonella typhimurium
Length
291 amino acids
Function
Has cefotaxime-hydrolyzing activity.
Similarity
Belongs to the class-A beta-lactamase family.
Mass
31.252 kDa
Sequence
MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGVALINTADNSQILYLADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKASDLVNYNPIAEKHVNGTMTLAELGAGALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNSAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKCWVVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAESRRDVLAAAAKIVTHGF

Gene
bla
Protein
Beta-lactamase CTX-M-6
Organism
Salmonella typhimurium
Length
291 amino acids
Function
Has cefotaxime-hydrolyzing activity.
Similarity
Belongs to the class-A beta-lactamase family.
Mass
31.207 kDa
Sequence
MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGVALINTADNSQILYVADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIRASDLVNYNPIAEKHVNGTMTLAQLGAGALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNSAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKSWGVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAESRRDVLAAAAKIVTHGF

Gene
bla
Protein
Beta-lactamase CTX-M-97
Organism
Escherichia coli
Length
291 amino acids
Function
Is probably capable of hydrolyzing cephalosporins such as ceftriaxone and ceftazidime, thus conferring resistance to these antibiotics.
Similarity
Belongs to the class-A beta-lactamase family.
Mass
31.279 kDa
Sequence
MMTQSIGRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAESRRDILAAAAKIVTHGF

Gene
bla
Protein
Beta-lactamase Toho-2
Organism
Escherichia coli
Length
289 amino acids
Function
Hydrolyzes beta-lactam antibiotics such as penicillin G, carbenicillin, cephaloridine, cefoxitin, cefotaxime, ceftazidime, and aztreonam. Has especially increased relative hydrolysis rates for cephalothin, cephaloridine, cefotaxime and ceftizoxime.
Similarity
Belongs to the class-A beta-lactamase family.
Mass
30.745 kDa
Sequence
MVTKRVQRMMSAAAACIPLLLGSPTLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTARAGADVASLRWVMRWAKPSGAVGDVAQRQYDRAAGIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL

Gene
bla
Protein
Beta-lactamase TEM
Organism
Escherichia coli
Length
286 amino acids
Function
TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
Similarity
Belongs to the class-A beta-lactamase family.
Mass
31.515 kDa
Sequence
MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW

Gene
bla
Protein
Beta-lactamase TEM
Organism
Salmonella typhi
Length
286 amino acids
Function
TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins.
Similarity
Belongs to the class-A beta-lactamase family.
Mass
31.515 kDa
Sequence
MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW

Gene
bla
Protein
Beta-lactamase SHV-1
Organism
Escherichia coli
Length
286 amino acids
Similarity
Belongs to the class-A beta-lactamase family.
Mass
31.224 kDa
Sequence
MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR

Gene
bla
Protein
Beta-lactamase SHV-1
Organism
Klebsiella pneumoniae
Length
286 amino acids
Similarity
Belongs to the class-A beta-lactamase family.
Mass
31.224 kDa
Sequence
MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR

Gene
bla
Protein
Beta-lactamase SHV-24
Organism
Escherichia coli
Length
286 amino acids
Function
Hydrolyzes ampicillin. Can also hydrolyze cephaloridine, aztreonam and ceftazidime with a low catalytic rate.
Similarity
Belongs to the class-A beta-lactamase family.
Mass
31.166 kDa
Sequence
MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARGTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR

Gene
bla
Protein
Beta-lactamase SHV-29
Organism
Klebsiella pneumoniae
Length
286 amino acids
Similarity
Belongs to the class-A beta-lactamase family.
Mass
31.184 kDa
Sequence
MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGSVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAAERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR

Gene
bla
Protein
Beta-lactamase SHV-2
Organism
Escherichia coli
Length
286 amino acids
Function
This enzyme hydrolyzes cefotaxime, ceftazidime and other broad spectrum cephalosporins.
Similarity
Belongs to the class-A beta-lactamase family.
Mass
31.254 kDa
Sequence
MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR

Gene
bla
Protein
Beta-lactamase SHV-2
Organism
Klebsiella pneumoniae
Length
286 amino acids
Function
This enzyme hydrolyzes cefotaxime, ceftazidime and other broad spectrum cephalosporins.
Similarity
Belongs to the class-A beta-lactamase family.
Mass
31.269 kDa
Sequence
MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR

Gene
bla
Protein
Beta-lactamase SHV-2
Organism
Klebsiella pneumoniae subsp. ozaenae
Length
286 amino acids
Function
This enzyme hydrolyzes cefotaxime, ceftazidime and other broad spectrum cephalosporins.
Similarity
Belongs to the class-A beta-lactamase family.
Mass
31.254 kDa
Sequence
MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR

Gene
bla
Protein
Beta-lactamase SHV-2
Organism
Salmonella typhimurium
Length
286 amino acids
Function
This enzyme hydrolyzes cefotaxime, ceftazidime and other broad spectrum cephalosporins.
Similarity
Belongs to the class-A beta-lactamase family.
Mass
31.269 kDa
Sequence
MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR

Gene
bla
Protein
Beta-lactamase SHV-34
Organism
Escherichia coli
Length
286 amino acids
Function
Hydrolyzes ceftazidime and cefotaxime.
Similarity
Belongs to the class-A beta-lactamase family.
Mass
31.147 kDa
Sequence
MRYFRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGSVGMIEMDLASGRTLTAWRADGRFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR

Gene
bla
Protein
Beta-lactamase SHV-13
Organism
Klebsiella pneumoniae
Length
286 amino acids
Function
Broad spectrum beta-lactamase which hydrolyzes penicillins, as well as cephalosporins except cephamycins. Also hydrolyzes aztreonam, but not imipenem. Confers highly resistance to ceftazidime, cefotaxime, aztreonam and piperacillin.
Similarity
Belongs to the class-A beta-lactamase family.
Mass
31.253 kDa
Sequence
MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAAERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR

Gene
bla
Protein
Beta-lactamase SHV-3
Organism
Klebsiella pneumoniae
Length
286 amino acids
Function
This enzyme hydrolyzes cefotaxime, ceftazidime and other broad spectrum cephalosporins.
Similarity
Belongs to the class-A beta-lactamase family.
Mass
31.211 kDa
Sequence
MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQLQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR

Gene
bla
Protein
Beta-lactamase SHV-46
Organism
Klebsiella oxytoca
Length
286 amino acids
Similarity
Belongs to the class-A beta-lactamase family.
Mass
31.266 kDa
Sequence
MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLNSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR

Gene
bla
Protein
Beta-lactamase SHV-5
Organism
Klebsiella pneumoniae
Length
286 amino acids
Function
SHV enzymes hydrolyze broad spectrum cephalosporins notably cefotaxime and ceftazidime. SHV-5 causes particularly high levels of resistance to aztreonam and ceftazidime.
Similarity
Belongs to the class-A beta-lactamase family.
Mass
31.253 kDa
Sequence
MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR

Gene
bla
Protein
Beta-lactamase SHV-5
Organism
Pseudomonas aeruginosa
Length
286 amino acids
Function
SHV enzymes hydrolyze broad spectrum cephalosporins notably cefotaxime and ceftazidime. SHV-5 causes particularly high levels of resistance to aztreonam and ceftazidime.
Similarity
Belongs to the class-A beta-lactamase family.
Mass
31.253 kDa
Sequence
MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR

Gene
bla
Protein
Beta-lactamase SHV-8
Organism
Escherichia coli
Length
286 amino acids
Function
SHV enzymes hydrolyze broad spectrum cephalosporins notably cefotaxime and ceftazidime.
Similarity
Belongs to the class-A beta-lactamase family.
Mass
31.223 kDa
Sequence
MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARNTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR

Gene
bla
Protein
Beta-lactamase OXA-9
Organism
Klebsiella aerogenes
Length
274 amino acids
Function
Oxacillin-hydrolyzing beta-lactamase. Confers resistance to beta-lactam antibiotics but at a significantly lower level than the TEM bla gene product.
Similarity
Belongs to the class-D beta-lactamase family.
Mass
30.568 kDa
Sequence
MKKILLLHMLVFVSATLPISSVASDEVETLKCTIIADAITGNTLYETGECARRVSPCSSFKLPLAIMGFDSGILQSPKSPTWELKPEYNPSPRDRTYKQVYPALWQSDSVVWFSQQLTSRLGVDRFTEYVKKFEYGNQDVSGDSGKHNGLTQSWLMSSLTISPKEQIQFLLRFVAHKLPVSEAAYDMAYATIPQYQAAEGWAVHGKSGSGWLRDNNGKINESRPQGWFVGWAEKNGRQVVFARLEIGKEKSDIPGGSKAREDILVELPVLMGNK

Gene
bla
Protein
Beta-lactamase OXA-9
Organism
Klebsiella pneumoniae
Length
274 amino acids
Function
Oxacillin-hydrolyzing beta-lactamase. Confers resistance to beta-lactam antibiotics but at a significantly lower level than the TEM bla gene product.
Similarity
Belongs to the class-D beta-lactamase family.
Mass
30.568 kDa
Sequence
MKKILLLHMLVFVSATLPISSVASDEVETLKCTIIADAITGNTLYETGECARRVSPCSSFKLPLAIMGFDSGILQSPKSPTWELKPEYNPSPRDRTYKQVYPALWQSDSVVWFSQQLTSRLGVDRFTEYVKKFEYGNQDVSGDSGKHNGLTQSWLMSSLTISPKEQIQFLLRFVAHKLPVSEAAYDMAYATIPQYQAAEGWAVHGKSGSGWLRDNNGKINESRPQGWFVGWAEKNGRQVVFARLEIGKEKSDIPGGSKAREDILVELPVLMGNK

Gene
bla
Protein
Beta-lactamase OXA-5
Organism
Pseudomonas aeruginosa
Length
267 amino acids
Function
Hydrolyzes both oxacillin and methicillin.
Similarity
Belongs to the class-D beta-lactamase family.
Mass
29.432 kDa
Sequence
MKTIAAYLVLVFYASTALSESISENLAWNKEFSSESVHGVFVLCKSSSNSCTTNNAARASTAYIPASTFKIPNALIGLETGAIKDERQVFKWDGKPRAMKQWEKDLKLRGAIQVSAVPVFQQIAREVGEIRMQKYLNLFSYGNANIGGGIDKFWLEGQLRISAFNQVKFLESLYLNNLPASKANQLIVKEAIVTEATPEYIVHSKTGYSGVGTESSPGVAWWVGWVEKGTEVYFFAFNMDIDNESKLPSRKSISTKIMASEGIIIGG

Gene
bla
Protein
Beta-lactamase OXA-7
Organism
Escherichia coli
Length
266 amino acids
Function
This is an oxacillin-hydrolyzing beta-lactamase.
Similarity
Belongs to the class-D beta-lactamase family.
Mass
29.461 kDa
Sequence
MKTFAAYVITACLSSTALASSITENTFWNKEFSAEAVNGVFVLCKSSSKLACATNNLARASKEYLPASTFKIPNAIIGLETGVIKNEHQIFKWDGKPRAMKQWERDLSLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFLESLFLNKLSASKENQLIVKEALVTEAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKGAEVYFFAFNMDIDNENKLPLRKSIPTKIMASEGIIGG

Gene
bla
Protein
Beta-lactamase SHV-4
Organism
Klebsiella pneumoniae
Length
265 amino acids
Function
SHV enzymes hydrolyze broad spectrum cephalosporins notably cefotaxime and ceftazidime. SHV-4 causes particularly high levels of resistance to aztreonam and ceftazidime.
Similarity
Belongs to the class-A beta-lactamase family.
Mass
28.86 kDa
Sequence
SPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQLQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR

Gene
bla
Protein
Beta-lactamase SHV-6
Organism
Klebsiella pneumoniae
Length
260 amino acids
Function
SHV enzymes hydrolyze broad spectrum cephalosporins notably cefotaxime and ceftazidime.
Similarity
Belongs to the class-A beta-lactamase family.
Mass
28.157 kDa
Fragment
single
Sequence
LLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARATTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERN