bkdA

Gene

bkdA

Protein

2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

Organism

Dictyostelium discoideum

Length

441 amino acids

Function

The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).

Similarity

Belongs to the BCKDHA family.

Mass

50.326 kDa

Sequence

MISQSYRILSRISRNNELKKTFLTNLNCKSSSPSIIRSFCKKQNLDENFEYTNKLEVQELKHYIPCYTIMDQEGVVSKPDQDPNFSKEEVIKMYTTMLTLNVMDSILYDVQRQGRISFYMTSFGEEAIHIGSAAALEMSDTIFAQYRETGVFMWRGFTINDIINQCCTNEHDLGKGRQMPMHFGSRKINLQTISSPLTTQLPQAVGSSYAQKLAGEKNCTIVYFGEGAASEGDFHAAMNFAAALSTPTIFFCRNNKWAISTPSKEQYKGDGIAGRGPNGYGMKTIRVDGNDIWAVYNVTKLARKIAVEEQVPVLIEAMTYRVGHHSTSDDSSRYRTVEEINAWKEGKNPISRLRNYMNHKGWWSDAQEKETIANARTTVRESLVNAEKQYKPSINEIFTDVYDKPTPNLIEQQKELIEHLKLYPDEYPLNQFADSKLILKD

Protein

2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial: bkdA

Gene

bkdA

Protein

3-methyl-2-oxobutanoate dehydrogenase subunit alpha

Organism

Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

Length

367 amino acids

Function

Component of the branched-chain alpha-ketoacid dehydrogenase (BCKADH) complex, that catalyzes the overall conversion of branched-chain alpha-ketoacids to acyl-CoA and CO(2).

Mass

40.616 kDa

Sequence

MGEGSRRPSGMLMSVDLEPVQLVGPDGTPTAERRYHRDLPEETLRWLYEMMVVTRELDTEFVNLQRQGELALYTPCRGQEAAQVGAAACLRKTDWLFPQYRELGVYLVRGIPPGHVGVAWRGTWHGGLQFTTKCCAPMSVPIGTQTLHAVGAAMAAQRLDEDSVTVAFLGDGATSEGDVHEALNFAAVFTTPCVFYVQNNQWAISMPVSRQTAAPSIAHKAIGYGMPGIRVDGNDVLACYAVMAEAAARARAGDGPTLIEAVTYRLGPHTTADDPTRYRSQEEVDRWATLDPIPRYRTYLQDQGLWSQRLEEQVTARAKHVRSELRDAVFDAPDFDVDEVFTTVYAEITPGLQAQREQLRAELARTD

Protein

3-methyl-2-oxobutanoate dehydrogenase subunit alpha: bkdA

Gene

bkdA

Protein

3-methyl-2-oxobutanoate dehydrogenase subunit alpha

Organism

Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Length

367 amino acids

Function

Component of the branched-chain alpha-ketoacid dehydrogenase (BCKADH) complex, that catalyzes the overall conversion of branched-chain alpha-ketoacids to acyl-CoA and CO(2).

Mass

40.616 kDa

Sequence

Protein

3-methyl-2-oxobutanoate dehydrogenase subunit alpha: bkdA