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bcdin3d

Gene
BCDIN3D
Protein
RNA 5'-monophosphate methyltransferase
Organism
Homo sapiens
Length
292 amino acids
Function
O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA, acting as a capping enzyme (PubMed:28119416). Less efficiently, also methylates the 5' monophosphate of pre-miRNAs, acting as a negative regulator of miRNA processing (PubMed:23063121, PubMed:28119416). The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Able to mediate methylation of pre-miR-145, as well as other pre-miRNAs (PubMed:23063121). There is some controversy about the methylation of pre-miR-145, since the dimethylation first described as the specific enzymatic activity cannot be reproduced by a more recent work which observes a monomehtylation of pre-miR-145 but two orders weaker than the methylation of cytosolic histidyl tRNA (PubMed:23063121, PubMed:28119416, PubMed:30127802).
Similarity
Belongs to the methyltransferase superfamily.
Mass
33.2 kDa
Sequence
MAVPTELDGGSVKETAAEEESRVLAPGAAPFGNFPHYSRFHPPEQRLRLLPPELLRQLFPESPENGPILGLDVGCNSGDLSVALYKHFLSLPDGETCSDASREFRLLCCDIDPVLVKRAEKECPFPDALTFITLDFMNQRTRKVLLSSFLSQFGRSVFDIGFCMSITMWIHLNHGDHGLWEFLAHLSSLCHYLLVEPQPWKCYRAAARRLRKLGLHDFDHFHSLAIRGDMPNQIVQILTQDHGMELICCFGNTSWDRSLLLFRAKQTIETHPIPESLIEKGKEKNRLSFQKQ

Gene
BCDIN3D
Protein
RNA 5'-monophosphate methyltransferase
Organism
Pongo abelii
Length
292 amino acids
Function
O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA, acting as a capping enzyme. Less efficiently, also methylates the 5' monophosphate of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Able to mediate methylation of pre-miR-145, as well as other pre-miRNAs. There is some controversy about the methylation of pre-miR-145, since the dimethylation first described as the specific enzymatic activity cannot be reproduced by a more recent work which observes a monomehtylation of pre-miR-145 but two orders weaker than the methylation of cytosolic histidyl tRNA.
Similarity
Belongs to the methyltransferase superfamily.
Mass
33.347 kDa
Sequence
MAVPTELHGGSVKETAAEKESRVLEPGAAPFGNFPHYSRFHPPEQRLRLLPPELLRQLFPESPENGPILGLDVGCNSGDLSVALYKHFLSLPDGKTCSDASREFRLLCCDIDPVLVKRAEKECPFPDALTFITLDFMNQRTRKVLLSSFLSQFGRSVFDIGFCMSITMWIHLNHGDHGLWEFLARLSSLCRYLLVEPQPWKCYRAAARRLRKLGLHDFDHFHSLTIRGDMPNQIVQILTQDHGMELICCFGNTSWDRSLLLFRAKQTIETHPIPESLIEKGKEKNRLSFQKQ

Gene
BCDIN3D
Protein
RNA 5'-monophosphate methyltransferase
Organism
Bos taurus
Length
292 amino acids
Function
O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA, acting as a capping enzyme. Less efficiently, also methylates the 5' monophosphate of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Able to mediate methylation of pre-miR-145, as well as other pre-miRNAs. There is some controversy about the methylation of pre-miR-145, since the dimethylation first described as the specific enzymatic activity cannot be reproduced by a more recent work which observes a monomehtylation of pre-miR-145 but two orders weaker than the methylation of cytosolic histidyl tRNA.
Similarity
Belongs to the methyltransferase superfamily.
Mass
33.49 kDa
Sequence
MAASTEQATGGVEKTAAEEKPRVLEPGAAPFGNFPHYSRFHPPEQRLRLLPPELLRRLFPQSPETRPILGLDVGCNSGDLSVALYKHFLSLHDGETCLDASRELHLLCCDIDPVLVERAEKECPFPDGLTFITLDFMNQRTRKVLLSSFLSQFGRSVFDIGFCMSVTMWIHLNHGDQGLWEFLAHLSSLCRYLLVEPQPWKCYRAAARRLRKLGLHDFDHFRSLAIRGDMASQIVQILTQDHGMELVCCFGNTKWDRSLLLFRTKQATETHPIPESLIEEGKERNRIRFWRE

Gene
Bcdin3d
Protein
RNA 5'-monophosphate methyltransferase
Organism
Mus musculus
Length
285 amino acids
Function
O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA, acting as a capping enzyme. Less efficiently, also methylates the 5' monophosphate of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Able to mediate methylation of pre-miR-145, as well as other pre-miRNAs. There is some controversy about the methylation of pre-miR-145, since the dimethylation first described as the specific enzymatic activity cannot be reproduced by a more recent work which observes a monomehtylation of pre-miR-145 but two orders weaker than the methylation of cytosolic histidyl tRNA.
Similarity
Belongs to the methyltransferase superfamily.
Mass
32.035 kDa
Sequence
MAADGTLSRGGVGEAVEEEHPGALEPGAAPFGNFPHYSRFHPPEQRLRLLPPELLRQLFPPEGPEKRPILGLDVGCNSGDLSVALYKHFLSPRDGETCSGASRELRILCCDIDPVLVERAERDCPFPEALTFITLDIMDQESRKVPLSSFLSQFGRSVFDMVFCMSVTMWIHLNHGDRGLCEFLAHVSSLCSYLLVEPQPWKCYRAAARRLRKLGLHSFDHFRSLAIRGDMAKQIVRILTQDHGMELACCFGNTSWDRSLLLFRAKHTHETQAIPESSTKETRTD

Gene
Bcdin3d
Protein
RNA 5'-monophosphate methyltransferase
Organism
Rattus norvegicus
Length
285 amino acids
Function
O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA, acting as a capping enzyme. Less efficiently, also methylates the 5' monophosphate of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Able to mediate methylation of pre-miR-145, as well as other pre-miRNAs. There is some controversy about the methylation of pre-miR-145, since the dimethylation first described as the specific enzymatic activity cannot be reproduced by a more recent work which observes a monomehtylation of pre-miR-145 but two orders weaker than the methylation of cytosolic histidyl tRNA.
Similarity
Belongs to the methyltransferase superfamily.
Mass
32.002 kDa
Sequence
MAATQELSKGGVEEAVEEDDPAALKPGAAPFGNFPHYSRFHPPEQRLRLLPPELLRQLFPPEGPERRPILGLDVGCNSGDLSMALYKHFLSPHDGETSSGTSRELRLLCCDIDPVLVERAENGCRFPDALTFITLDIMDQESRKVPLSSFLSQFGRSVFDIVFCMSVTMWIHLNHGDRGLCEFLAHVSSLCSYLLVEPQPWKCYRAAARRLRKLGLHNFDHFRSLAIRGDMASQIVRILTQDHGMELACCFGNTSWDRSLLLFRAKHTEETQAIPESSTKETGTD

Gene
bcdin3d
Protein
Pre-miRNA 5'-monophosphate methyltransferase
Organism
Xenopus laevis
Length
255 amino acids
Function
O-methyltransferase that specifically dimethylates the 5' monophosphate of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by dicer1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by dicer1 (By similarity).
Similarity
Belongs to the methyltransferase superfamily.
Mass
28.629 kDa
Sequence
MSNSESVPHVDPGAAPYGNFPNYYSFNPPENRISLLPAELLHKLFRKPAESDSSTQPLLGLDVGCNTGDLSVALYNHLTEPHSKSSDVPVHFLCCDIDPDLITRARASNPFPDFISYATLDIMDSSAVRGPVNDFLQQFARSTFDIAFCMSVTMWIHLNYGDQGLVTFLGHLANLCDYLLVEPQPWKCYRSAARRLRKLGRQDFDHFHSLSIRGDMAENITQILTAEGAAKLIHIFGNTSWDRSLLLFKIQRHPC

Gene
bcdin3d
Protein
Pre-miRNA 5'-monophosphate methyltransferase
Organism
Danio rerio
Length
254 amino acids
Function
O-methyltransferase that specifically dimethylates the 5' monophosphate of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by dicer1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by dicer1 (By similarity).
Similarity
Belongs to the methyltransferase superfamily.
Mass
28.819 kDa
Sequence
MEAHDAHVNSEESENPGAAPYGNFINYYTFNPPENRLSLIPEALLQNIGFTSGDGERVLMLDVGCNSGDLSVALYKHLLNKEACTSDSPRQELYMLGFDLDQDLILRAQTSNPFPQNIQFIPLDITDDTESRAVLQAFLGKFGCSRFHLSTCFAVTMWVHLNHGDAAFLSLLSRLASHSEYLLLEAQPWKCYRSAARRLRKLGRSDFDHFKALKIRGDMAAHAREHLEKQCSMELVQCFGNTSWDRSLLLFRRQ