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bbs-1

Gene
bbs-1
Protein
Bardet-Biedl syndrome 1 protein homolog
Organism
Caenorhabditis elegans
Length
576 amino acids
Function
Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for proper BBSome complex assembly and its ciliary localization (PubMed:22922713). Required for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme (PubMed:15231740, PubMed:22022287, PubMed:22922713).
Mass
64.552 kDa
Sequence
MAKPVNVNQSKWTVPVLLKECEIYCPSTCVAFGPILSDNDSKLIIAHGGHRGVNMKLKVFQQLEQLSESSLADMPTALVHFINDLSSIPSIAVAAGPSLLIYKNLKPFYKFTVPSSAINPTESEAWKAVVNKKINGDTLLTVLKRLEDDVAFSKLTPISQTYLRADKETQVVLVEHYGTKIANSATITCIAKLTKSTAEPLDILVIGTEHCEIFLIDSQAFTILETIKIGSVPVNICAYGTYDVDYRLFVQTRASLIFCMKRGEADYQPIVISQSMITSMVLVNKMIVYTTVENLIHFASFRGKKMNTVKCPSKIKMLEPFIYPLKQLAAVIAVFDKEIRMYNEHYLLDTVQYEKPLAWVKYGCYGREDSTLVVAFKDGSIAIQIFRRKANFDTKLDYNQVPQAHALKLQIPKKTKVFIDLTQREVQLGNRIHKVYQKNLFDVKYRLAASYLELTSSASATVSTTTVLPVEISVDIHGFGPTFRMTIHLLSSSKQNLYDMHLSIISDPELYDFDTPLIPVHLLASGQSYSFTTLLYCKDPEKAANCDVRALLVHAKRATPIVTAVIKMPFSEFPLD