Function
Required for the maturation but not the establishment of septate junctions in developing epithelial cells and is involved in epithelial cell adhesion during septate junction maturation (PubMed:25704509). Plays a role in the proper localization of the septate junction core components pck/mega, kune, Nrx-IV and Nrg during late embryogenesis (PubMed:25704509). Involved in the formation of tricellular junctions which mediate cell contact where three epithelial cells meet but not of bicellular junctions (PubMed:25982676). Required for the accumulation of Gli at tricellular junctions.
Sequence
MKLQHHKTNRQRISKPHRDPKWASICLWLLVTLAFSTHLARSQESRQTEDSKEVELLQDNDIEFASLDGASQLLPATRHSGADVTVAPQGSTPSMTSSSSYTELQGGEILSDRILRRSESPYLARDDIEVLRGARLTIEPGVTIEFAPTKGLKINGVLQAVGTPTSRIVLKSQSNTANYKLELPDDQEKGIRLVDGPTPVEGRLQLFHKGAWRSVCSNSRNWTLADYGVACKQLGYRGGRFWNWVERTPGYYPRLLYEQPKCKGGEGSLQDCAWTSRQMGAGACDYHNDLGIQCLPVHSETLGHWRGIYFDNAPSTKALGRDNIVYAAQSESRLKYVDIIRAGSGAGFNAKSAVEVQGLPPQMEHVVISHSAYTGFNSTRPWAGFQLQNVTVRKCNGIGVFVNSSQGAVQLDGCSIVDNAGDGIKYVGHDLRGTERKDRASIYDFCTLPTTSGQTYPISLSFTQKYYAGSGKECGKYFFTRPGYLLTLHFENFVLMQNETATVEIYDGASTNDRLLFEWKARNFTRPQSVTSTREKMFVRIRADARQELNGFFRMTSGDSVAYDLKVSQSTVEDNGGRGVAIDNIRSKLHVHSSSVSGNGHVAGVHVTSGAGDVNITSSNISFNNGAGVNITYYGGNRNISRSALTANKGYGVATWLNQTSDVNRMEYIPFNQTSVVEYSQIGGNLETGVFHGNFCRPIWVNITGNSFNGSQQNDIFIESCYQATANGRPNMQLQLGHNQFKYSQANSIYLSPALNLQGRIEYNMFRFGSYGCLFINNDYIYPEFNYFPVKLIIQSNYFMRNSGVHVVSLGLSPYSRAEVQYILFTRNFVRGNNITEAFGPLIAGSEGSDGAGRLNPRSRVAAPVVVGSSNVDIFRNILHNLDSMYEIGSQLTDQSKIINATCNWLGHTDENKIYARLFHRNDRYNLAKINYLPYLLHSSNPGSTAMITVSTVVPRFFHEGSDVIGGEVDGQDMVPAGTYTVTKDINIRPGGKLILQPGTTLKFEPSVGMMVAGKLEARGRRPDDILFTLKRETIMGESNDTETIDLDSETEAIDMETEVIPADGVPRVPVRLVGGAGANEGRLQVYLKGRWGTVCDYGWNVLNAALVCHQLGYSLNPQDWRLLRSQLPNAGTSEDILMANVRCTLQDRDVTKCRAEYEFENTCSHENDVGLRCYEGAWAGVRFSMLAERADLQYVTVEKAGLFDYTTNAFKPAVQMDHARHNLENVRIVNNLQDGLGIIYADIYAGKSVNNIKNSEFSGNKGSGISLKQLDFRVSGSIIKDNKGSGVSHDAVISALDQKEIGGWFNMATDFNSFDTDYDPYLLPREISNIDLGTFEHKYIRTEELLGQNINRKIVVQCPAGYVIGIQLLNPIHNLSTESINILNARTENIRSDLWQVKRDLNVFPVTSSSYGIIIYYESGLQALGGAVLMLSTVTAPVQNIRNRIVSGAVPTLTIRSTKIQKNLRGITGIYYNRYIGDNGEYYLRKANESIKLINSELSYNEREAILIRSPFWDVISSNLSEVTLHVNGSLITQNGLGIRQMSKDLRSSNNLFHYVIQDTTFEQNTHGGFQVSLPYVWQYNENFTHSIYFGNSTWQRNRDFRISVSGHYTVFNITSNVFRENNCPGALISLDGMEKRLRFDNNRFESNNAKFVLLFKADSLSEIIGQVPASIEFNSFKGNNIVTMTANYRNHYMKVARRIRKQHKIPTAVIRLDGVQNVRLYRNLIAENEMDYNLVAGVRSARLNNYFEARENWWGTKDTAFIEAKIFDFDNWNDHADVIYQPFLIEDSYDASVSVVVPFNQDQEIDLTNYKGGRVYKDLLLTKQSTPYYISSDITVMPGKTLTINHGVTMEFEPNVGILVLGTLVAIGYRESPIVMRPFRNATRESLIDVQPKKRALEDMSAPLTEFDSIRLCTSANNCTGDADGLFGLNEGFLEYFNHTTLQWVPICDSRFTERNAQVVCRELGYDPLNVYYGHDRRIEFHTNSLTRIWSWVQPLECRGDEERMEDCAERLNGQLYGHRHECRWDDVFVFVSCNGIADDEVYWGGIRFANSKFEEIQYEHRLHNTRSHARLPLRESQLEFVRIEQAGILHNHKAAAIQAIHKNPSITSVSIENSANHGINMIAPSGKLNLNHLNINNTLGTGISIVSLSGEGRDSDESSFTPLKKLDLPYKLFSLVDICDPQKVLTIEERMLIYYKYDNNPVNCVKIFTSAFRAKPIGFRLLQSNLFNHSKLYGRTDFIKLYDGDIYNVTATYLGKIESDTDNQRSFFKTKGPTMSLQLVASGAPETHGFIAEVVTVPISTLGQYRDALHNITDTHISGAIKGAVTYSSAGEVTPTLTLIGNRIEKNCRQLYGNFSTCTSALNLDVQNMNSLYFMNNLITENQGGLRIRADSRGSATSLRGFVHHNLFMRNRNRPALYVEGRQSSPYQEVELYRNYFAQNMAGYEDVIRLCQVVSNFSYNYVHSNVGGRIMEVSGFEKVRLQIYQTTAHNGFYRNFATNWMTRATIVAGTAGQQYVDNIFENHENDYELLTVNNSILSFDYENRTFETWSSKIDARHNYWSYNNTISVQSRIRDKSDDPMLLEVLAVPFQMNNETILDGKCPPGWALVHDTCFIYVGAPMTFHEARDFCRSENSTMPFIRTDKTTLWKYLQSQMRHLKYPDKVWIQDYNHIDRCTSFVFGEIEIEDCNKERGFICESDPRVIIDPLSWRADIFAISIISAFVLAIILLILVAFCWFAKSKHRHTQRLQRRNSIRQSLRSLNSIDPQGSLRRRPNYNMSSNGTLSKGQDYKQMVANGSIDSMDKSVLSSEAGSFEGYEQKPHYNEYVNQNALRPAHPAQDHQSHKVATISKASGHRARAAAAAAAALEPDAFELSYRNEGFRDNSTYGDNTRANSISTSVAEDTPIIHHTDQEIDEGGSDYYGNASTLPLRTEGGTPAGRRGQPGLAFLSELKQNLPEYQRSSHSSFMPHRSSGDSLPFDQKLDQFNYSTESSLYRPAPAVPSSQQATPADMRRPDSYYTAVRSSKAPVSHYRTPRPLAQPPAAPNVAPAGGPAQRRPKTVYQTASEESSPTTPSPLTNQYHRSKSEALLETDFDGDGGSVGLQPLQTNGRSHSQPLETAM