Protein
Nucleosomal histone kinase 1
Organism
Drosophila melanogaster
Function
Serine/threonine-protein kinase involved in somatic mitosis and female meiosis (PubMed:16230526). Required for spindle organization in mitosis, and for the establishment or maintenance of meiosis-specific chromosomal configurations, including the prophase I karyosome and the metaphase I spindle (PubMed:15078818, PubMed:16301329). Specifically phosphorylates nucleosomal H2A on 'Thr-119' (PubMed:15078818). Required for the development and organization of indirect flight muscle sarcomeres by regulating the formation of M line and H zone and the correct assembly of thick and thin filaments in the sarcomere (PubMed:26251439).
Similarity
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.
Sequence
MPRVAKPKAAAPAKKVVSAKKAKSKLYKMPEKVKEGTVFTDLAKGQWRIGPSIGVGGFGEIYAACKVGEKNYDAVVKCEPHGNGPLFVEMHFYLRNAKLEDIKQFMQKHGLKSLGMPYILANGSVEVNGEKHRFIVMPRYGSDLTKFLEQNGKRLPEGTVYRLAIQMLDVYQYMHSNGYVHADLKAANILLGLEKGGAAQAYLVDFGLASHFVTGDFKPDPKKMHNGTIEYTSRDAHLGVPTRRADLEILGYNLIEWLGAELPWVTQKLLAVPPKVQKAKEAFMDNIGESLKTLFPKGVPPPIGDFMKYVSKLTHNQEPDYDKCRSWFSSALKQLKIPNNGDLDFKMKPQTSSNNNLSPPGTSKAATARKAKKIDSPVLNSSLDEKISASEDDEEEEEKSHRKKTAKKVTPSARNAKVSPLKRVADSSPPSQKRVKTEPKSTPRERATPKASPKPRSTPKASPKPQTPTAARLRTPNAKINFSPSISLRGRPGGKTVINDDLTPQPRSKKTYEFNFELDVSMDANVIVNVKRKKKADQDKATAVDSRTPSSRSALASSSKEEASPVTRVNLRKVNGHGDSSTPGRSPRTPAVTVRKYQG