bacC

Bacitracin synthase 3

6359 amino acids

Induces peptide synthesis, activates and incorporates five amino acids, forms a thiazoline ring between the first two amino acids and incoporates a D-glutamine in the fourth position.

Belongs to the ATP-dependent AMP-binding enzyme family.

722.943 kDa

MKTKVEKIYPLSNMQKGMLFHAMKDEASHAYFEQFIIELKGDVDERMFEESLNEVMKRHEILRASFHHRLDEPLHVIIKDRHMKFDYLDIRGRHDQDGVLERYLAEDRQKGFDLAKDTLMRACLIRMSDDSYQFVWTYHHILLDGWCLGIILDELLTIYEMKRKGQNHQLEDPRPYSDYIKWLEDQDKEEAQSYWESYLSGYDQKNSLPKLRTPSETGFKRREKTIECSKELTNRLIKLANRNHVTINTVLQSIWGVILAKYNNSEDVVFGTVVSGRDAEVEGIETMVGVFINTIPTRIRLDKDKLFKDVLRQTQADALESSRYNYMNLAEVQALSELKNDLIDHVMVFENYAVDQKAFEEKNDVGFEMVNVSGEEQTNYHFSISAALDDQLKLLFIYDENVYDTTIIETLEKHIITVAEQVAEDETQTLRDINLVSKEEQHRILDTFNDTKTGYPKDKPLHELFEEQAMKTPDHTALVFGAQRMTYRELNEKANQTARLLREKGIGRGSIAAIIADRSFEMIIGIIGILKAGGAYLPIDPETPKHRIAFMLSDTKAGVLLAQGKAADGIDCEADIIHLDKGVADGFSKKRLSSVNDSGDTAYIIYTSGSTGMPKGVVTPHYSAARVVKNTNYIDITEDDAILQLSNYSFDGSVFDIFGALLNGASLVLIEKETVLNTHELAEVIKKEQVSVMFITTALFNTLADINIGCLAKLRKIFLGGERASIPHVRKVLNHVGRDKLIHVYGPTESTVYATYYFINEIDDEAETIPIGSPLANTSVLIMDEAGKLLPIGVPGELCIAGDGLSKGYLNREELTAEKFIPHPFIPGERLYKTGDLAKWLPDGNIEFIGRIDHQVKIRGFRIELGEIESRLEMHEDINETIVTVREDEESRPYICAYITANREISLDELKGFLGEKLPEYMIPAYFVKMDKLPLTKNGKVDRKALPEPDRTAGAENEYEAPRNETEEKLAAIWRDILKVEKSGINDHFFEMGGHSLKAAAMAARIRKELKAEIPLGQIFKTPTIKGLGEYIRSTKDSVYSSIQKVEEKEYYRLSSAQKRLYILDQIEGSGLSYNIPFTMKVKGRFDIRRFENALKTIIQRHEALRTSFLMADGEPVQKIEKEVDFSIKCSKIQSLSIQEIIKQFVRPFDLKKAPLFRTEVVKVDDEEHIILFDMHHIISDGASMGVLTKEICDLYGGKELKPLSLQYKDYSEWQRDFYQKDEMKRQKEYWLNIFKGEIPVLNMPTDYPRPQMHSVEGDRIGFAIDGELTKKLKRIAKDNGATMYMLLLAAYTVLLRTYSGQEDVIIGTPIQGRKHHELKHVIGMFVNTLAMRNHPKGDKTFAEYLQDVKETALKAYENQDYQFDDLVEQLDLERDMSRNPLFDTMFVLQNLEKADAEIEGLTFEPFESDIHISKFDLTLSAIEKDSKIEFDLEYCTKLFKRETVERMAAHFVRVLEDISKRTDKRLDQIEAMSEDEKNTLLYRFNDTKTDAPTDKTICQLFAERAETSPDKTAVVFEDQTLTYRQLHERSNQLARFLREKGVQPDTAVGIMVDRSPEMIIGLLGILKAGGAYLPLDPAYPEDRIKYILGDSQTKFLLSEEALIKKRAFIKEADMINIDIHDKQIAAQDAAQLEPVSRSGDLAYIIYTSGSTGKPKGVLIEQKGLSNLVSAVVKLMHLNTGSRVIQFASLSFDASAFEIFPALAAGSALVLGRQEEMMPGQPLTSFLRQYNITHATLPPTVLDVLNESGLENLKVIVSAGSACSEELAKRWSGNRLFINAYGPTETTVCATAGIYEGSGRPHIGSPIANTNVYVLDQNQKPVPTGVVGELCVGGMSLARGYLNRPELTAEKFISHPFASGERLYRTGDLARWLPDGHLEFLGRIDHQVKIRGYRIELGEIENQLLKLDKIDEAAVIARKDDDHSDYLCAYIVSKEDWTSTEISEWLEKELPHYMIPAYFVRLDKLPLTSNDKVDRKALPAPDRHVATGAVYEAPRNDTEAKLVDIWRDVLGAGDIGISHHFFAAGGDSIKALQIVSRLSRLGLKLEMKDLFANPRIKDLAKYVKKQSQRKNANTIVTGHAELTPIQKWYFANNKEELDHFNQSFVLFRKGGFDESCVKKAFNKIMEQHDALRMIYEEKGGDFIQYNRSFREDLFDLDVYDVRGLDRQAEKVYELATSIQKLSSIRKGKLVHLGIFRADEGDHLLIVIHHLVVDGVSWRILFEDFETLYSQALKGQTLEIGYKTDSYQEFARRLKAYAHSRTLSKEAEYWRNIAKARVRFIPPKNVLKEDVYENSTTLSIKLGKEATADLLRNTNRAYNTEINDILLTALLTGARDITGENKLKVMMEGHGREDILEGVDITRTIGWFTTMYPVLLDAGEEKALSQQIKMVKETLRKIPNKGIGYGLLKYMAEDPDFTNEEKARISFNYLGDIDADMNRGEFSGSSFSEGESIGGKIARSHSIEINAIVMNHELVIHTTFNQMEYEKDTISRLNHQLKERLEQIIKHCTQQTESERTPSDYGDTNISLAELEEIKGKYRSAIEKIYPLANMQKGMLFHAIEDHTSDAYFQQTVMDIEGYVDPAILEASFNDIMKRHEILRASYEYEIVEEPRQIIIENRSIDFTYFNIAKSSAQQQEMFIERLLNEDRKKGFDLSKDVLMRAYLLKTAERSYRLVWSHHHILLDGWCLGIIMRELFVIYENRMNGKASPLKETKPYSDYIKWLERQDQEEARQYWREYLKGYEEQAQLPTLTKRKKSSRYDRREKVIHLSKQLTKQLKELAAKNSVTLHTVIQTIWGLMLTRYTKIDDVVFGTVVSGREANVDGIEDMIGLFINTIPTRIRFNEQARFNDCLQKVQEDAIQSNRYNYMNLAEVQALSSLKKDLIDHILVFENYEADEQDFEESQMKTGFKVNEISAAEQSITAFSMSVTPGEELTLVLTYDGNVYDRDIINNIEGHIKRVAEQVTANENRKIAEIDMLAEEERKTLLYEFNRTNADYPRNKTIHQLFEEQAERTPGHTAVVFEKEELSYKALNERSNQLAGLLREKGVKPDMIVGVMAERSVEMIVGMLAVLKAGGAYLPIDPEYPEDRIRYMIEDSGISILLKKADKQIDVDFTCIDMNEKGLAKDMAAENLGHTSGSSDMAYVIYTSGSTGKPKGVMVNHQSIVNTLYWRKQSYGYSTADATLQVPSFSFDSSVEDIFTTLISGAKLVLIRDLRMNPREIIGVLRTHKATNLLAVPSFYLNLLDTIEQPLDDLRFVTVAGEGFNESLIRQHFEKLPNVKLFNEYGPTENSVCSTRGELRKDDEKVVIGRPISNHKVYILNHNQQLLPLGTPGELCLSGEGLARGYLNRPDLTLEKFVPNPFAPGESMYRTGDLARFLPDGQIEYLGRIDHQVKIRGFRIELGEIENQLLKIEGIDAAAVMAREDQAGGKYLCAYIVADKAAGVADVRKCLLKELPDYMVPSYFVKLDQLPLTANGKIDRKALPEPSSTISEATYEAPRNRTEEKLVSIWEDVLGIENIGISHNFFELGGHSLKAAALTAKLHKEMKIEVPLRQLFETPTIKDIGDFIESMKESPYASITQAEEKEYYALSSAQRRLYILNQIEPGGLSYNMPFAMKIAGDFDVDRFEDAFRQLIERHEALRTAFVMVDGEPVQKIEKEVDFKVKYGRLGQDPLEEKIKAFIKPFALEKAPLLRAEVLKASGDEHVLMLDMHHIISDGVSMAIFTRELAELYEGKTLPPLTIQYKDFSEWQKLFYQKDEVKRQEDYWLNVFQGEVPVLNLPADEKRPQKRSIEGDIVQFEIDGETSAMLNKLAKENGATMYMLLLAGYTTLLAKYTGQEDIVVGSPIAGRHHSDLKHVIGLFINTLAMRNHPKGDMPFADYLKEVKETALKAYENQDYPFDELVEKLDVKRDMSRHPLFDTMLVLQNFDGDEADIDGLTFQPLQTEVNISKFDLTLTAAETNEGIQCVFNYSTKLFKRSTIERMAGHLINILKEAANDPHMPLSDVNMLSDEEMNALLDQNQGKQADYPQDQTVHQLFEQQADKTPEQTAVVYADEKLTYRELNERANQLARLLRDKGADADQPVAIMIEPSLEMIISMLAVLKAGAAYVPIEPEQLAKRTNEILSDSRAAILLVKGSVKENVAFAGEIVNVADGLIDAKVASNLSASGSADQNAYIIYTSGSTGKPKGVFVRHGNVVNYTTWFMKEAGLTENDKAMLVSSYAFDLGYTSIFSALLSGSELHIARKECYTNAHRALKYIKENGITYIKLTPSLFNIFVNDPGFSAEKPCATLRLVVLGGEMINTRDVETFYNQYPDHVVMNHYGPTETTIGSVFKVIDPEHLDSFKECPVIGTPIHNTNAYVLDENMKLLPEGVYGELCIAGAGVTGGYVNRPDETKEKFIENPFAPHTKMYRTGDLARRLSDGNIELAGRIDTQVKVRGYRIEPEEIKNRLLAHDDIKEAFIAAREDHKGAKQLCAYFTADAELPFEDIRTYLMHELPEYMIPSSFVQIEKMPLSANGKIDTAALPEPQPGKETEYEPPRNETEEKLVQIWEEVLGIDKIGITHHFFAAGGDSIKALQMISRLSREGLSLEMKDLFANPQIKSLSRYVKAESDKSASYETVEGEVLLTPIQQEYFSLNKTDRNHYNHAVMLYRKNGFDESIVKRVFKEIIKHHDALRTVFTEEDGKIIQYNRGPDKQLFDLFVYDVSSENDQPQKVYQLATELQQSIDIETGPLVKLAVFKTNNGDHLLIIIHHLVVDGISWRILFEDLAIGYSQLANGEKVEFYPKTASYQAYARHIAEYAKSVKLLSEKQYWLKAIAEGVEFLDMNENAGAFKVEDSRTFSTELEKEETKRLLRETNRAYHTEINDILITALLVAARDMNGQNQLRITLEGHGREQVADGIDISRTVGWFTSKYPVFIDLGQETDMSRTIKMVKEHLRNVPNKGIGYGILKYLTRDSEIAKGAASPILFNYLGQLDEDINSGEFSSSHLSPGEAAGKGITREHPLEINAVVFRGKLAIQTTYNTRAYSEDVVRAFAQNYKEALKAVIRHCAEREETEKTPSDYGDKGISLDQLEEIKLKYKGMEIEKIYPLANMQRGMLFHALEDKESQAYFEQMAINMKGLIDERLFAETFNDIMERHEILRASIEYEITDEPRNVIIKDRKINLDYHDLRKQSPAEREQVIQAYRKADREKGFRLNSEPLIRAALMRTEDDSYTFIWTNHHILLDGWSRGIIMGELFHMYHMKEARQKHRLEEARPYSDYIGWLQQQDKEAAKAYWRNYLSGFTEKSPISVLAGSSGHAKYKRKEAVIEFPEQLTGRITELASRNNVTFHTVLQCIWGMLLARYNQTDDVVFGTVISGRDAQVTGIEKMVGLFINTVPTRIRLDKSQSFKELIKSVQEQALEGRTYHDMNLSEVQSLSELKRELLDHILIFENYAVDQSAFETSGKRGAGFVFEEIHAEEQTNYGFNIVAVPGERLVIKLTYDGNIYHDHIIAGIKGHLQQVMEQVVQHEDQSLNDITVLSEAERNRLLYEWNDTKAEYPNQTIHRLFEEQAEKTPELAAVVSGNDKLTYRELNEKSNQLARYLRDKGVKADTIVAIMAERSPEMVVGIMGILKAGGAYLPIDPDYPEERIKYMLEDSGAAIILADHKQDLGTLHQEAVELTGDFSSYPADNLEPAGNADSLAYIIYTSGSTGKPKGVMIRQRGLVNYITWADRVYVQGEQLDFALYSSIAFDLTVTSIFTPLISGNRVIVYRHSEDGEPLIRKVFRDQKAGIVKLTPSHLSLVKDMDASGSSIKRLIVGGEDLKTELAKEITERFHHNIEIYNEYGPTETVVGCMIYQYDAGWDRQVSVPIGKPASNVQLYILDERQEVQPVGIAGELYISGDGVAKGYLNKPELTSEKFLPNPFLPGERMYRTGDLAKMRPDGHIEYLGRIDHQVKIRGYRIELGEIEHQLLRHSDIKEAAVAAKTDQNNDQVLCAYVVSERDITQKDIKTFLAKELPEYMVPSYLLKLDELPLTPNGKVDLKALPEPDRSAGALLEYEPPRHELEEKMAAIWEDILNIEQIGINANIFDIGANSLNVMSFVSRLYAELGFRVPFKDIFSKPTIKELSDFLKHAQDLLKDYTDDCMQLTRAEEGGKNLFCFPPAASMGIAYMGLAKHLKQHSVYSFNFIPSANRIRKYADIIKNIQGEGPYTLIGYSSGGILAFDVAKELNRQGYEVEDLIIIDSKYRTKAEKHQFTEEEYREEISKTFELEKYRDVEKLLSDYLVDLVMKSYVYIQNTVTTGAIDGHISYIKSSDNQRGENMMMWEKATSKTFTVVQGAGTHMQMISKSHPDILERNARLIHDIINKTVKI

bacC

Dihydroanticapsin 7-dehydrogenase

254 amino acids

Part of the bacABCDEFG operon responsible for the biosynthesis of bacilysin, an irreversible inactivator of the glutaminase domain of glucosamine synthetase. Catalyzes the dehydrogenation of the C7-hydroxyl group in the 4S-tetrahydrotyrosine (4S-H4Tyr) to yield anticapsin (epoxycyclohexanonyl-Ala).

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

27.368 kDa

MNLTDKTVLITGGASGIGYAAVQAFLNQQANVVVADIDEAQGEAMIRKENNDRLHFVQTDITNEPACQNAILSAVDKFGGLDVLINNAGIEIVAPIHEMELSDWNKVLNVNLTGMFLMSKHALKYMLKSGKGNIINTCSVGGVVAWPDIPAYNASKGGVLQTDAFYRPSIIAKHNIRVNCVCPGIIDTPLNEKSFLENNEGTLEEIKKEKAKVNPLLRLGKPEEIANVMLFLASDLSSYMTGSAITADGGYTAQ

bacC

Dihydroanticapsin 7-dehydrogenase

253 amino acids

Part of the bacABCDEFG operon responsible for the biosynthesis of bacilysin, an irreversible inactivator of the glutaminase domain of glucosamine synthetase. Catalyzes the dehydrogenation of the C7-hydroxyl group in the 4S-tetrahydrotyrosine (4S-H4Tyr) to yield anticapsin (epoxycyclohexanonyl-Ala).

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

27.293 kDa

MNLTDKTVLITGGASGIGYAAVQAFLNQQANVVVADIDEAQGEAMIRKENNDRLHFVHTDITDEPACQNAIRSAVDKFGGLDVLINNAGIEIVAPIHEMELSNWNKVLNVNLTGMFLMSKHALKYMLKSGKGNIINTCSVGGVVAWPDIPAYNASKGGVLQLTRSMAVDYAKHNIRVNCVCPGIIDTPLNEKSFLENNEGTLEEIKKEKAKVNPLLRLGKPEEIANVMLFLASDLSSYMTGSAITADGGYTAQ

bacC

Dihydroanticapsin 7-dehydrogenase

253 amino acids

Part of the bacABCDEFG operon responsible for the biosynthesis of bacilysin, an irreversible inactivator of the glutaminase domain of glucosamine synthetase. Catalyzes the dehydrogenation of the C7-hydroxyl group in the 4S-tetrahydrotyrosine (4S-H4Tyr) to yield anticapsin (epoxycyclohexanonyl-Ala). It is not able to oxidize the 4R-H4Tyr diastereomer and the dihydrobacilysin dipeptide (L-Ala-4S-H4Tyr dipeptide).

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

27.08 kDa

MNLTDKTVLITGGASGIGYAAVQAFLGQQANVVVADIDEAQGEAMVRKENNDRLHFVQTDITDEAACQHAVESAVHTFGGLDVLINNAGIEIVAPIHEMELSDWNKVLQVNLTGMFLMSKHALKHMLAAGKGNIINTCSVGGLVAWPDIPAYNASKGGVLQLTKSMAVDYAKHQIRVNCVCPGIIDTPLNEKSFLENNEGTLEEIKKEKAKVNPLLRLGKPEEIANVMLFLASDLSSYMTGSAITADGGYTAQ

Bacc

Bacchus

152 amino acids

Negatively regulates tyramine beta-hydroxylase tbh and thus the conversion of tyramine (TA) to octopamine (OA). In tyrosine decarboxylase 2 (Tdc2) neurons, acts in an amine-mediated signaling pathway to negatively regulate acute ethanol sensitivity probably via tbh-mediated depletion of TA.

15.46 kDa

MSAATEQQNNGDVAVEKVAADDVSAVKDDLKAKAAAEDKAAAADAAGDAADNGTSKDGEDAADAAAAAPAKESVKGTKRPAEAKSAESKKAKKAAAADGDSDEEEALEEIIEGDSEIESDEYDIPYDGEEDDIECDDDDDDNDDGSGSDDQA