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bacB

Gene
bacB
Protein
Bacitracin synthase 2
Organism
Bacillus licheniformis
Length
2607 amino acids
Function
Activates two amino acids and incorporate a D-ornithine from its second active site into bacitracin.
Similarity
Belongs to the ATP-dependent AMP-binding enzyme family.
Mass
297.479 kDa
Sequence
MSMSIMDFINDLKKKNITLYHNKGKIKIIGPQELLTADLKQQIKRYKEDIIAALEAGETDIERSFPKAAPSKSGTYPLSREQKRMFILNQLDDSKTAYNMPLAVKINGEVQISRLEQAWKALIKRHESLRTSFVMLDGEPVQKIEQEAEFRLEYSELGDQSIQEKISRFIKPFELEKAPLLRAEIVKVDEAEHMMMVDMHHIISDGVSIGILMKEFADCCEGKELSPLAVQYKDYSEWQRDIEQQSRLKKQEAYWLNTFRGDIPVLNMPLDFPRPKIRSFQGNRTVVELDQDTTKKLKTIAAKNGVTMYMLLLAGYTILLSKYTGQEDIIVGSPIAGRPHADLNGTIGMFVGTLALRNRPKGNMTFSEYVQTVKNNTLKAYENQDYQFDALIEHLGLTHDMSRNPLFDTMFDLQHADDFASEAGGGHFETYDIPFHVAKFDVSLTAFLHGDNLKFDFQYCTDLYKKETVERMAGHFLNVLKDAAHHPELALSEIRMMSEEEKDIILHTFNHEKTDGPKNKTLSRLFEERAEKTPDHTAVIFEDQQLTYRELNEKANQLAWLLREKGVKPDTIVAIMTDRSLEMIIGIIGILKAGGAYLPIDPDYPEDRVKYMLEDSGADMVVIQEPFKSKIDGRQLITAEDTRSFSKENLPNVNKASDLAYVIYTSGSSGRPKGVMTTHRNVVHYVDAFTKRIPLSEHDTVLQVVSFSFDAFSEEVYPILACSGRLVISRKVSDLNIDELVKTIGKYRVTLVSCSPLLLNEIDKNQHLTFHPQMKFISGGDVLKFEYVENIIKGADVYNSYGPTEATVCATYYQLSSADRKKTSIPIGKPLSNYKVYIADQYGRPQPVGVPGELLIGGEGVARGYLNHETLTKAAFVVDESGERVYRTGDLARWLSDGNIEFLGRIDSQVKIRGYRIELEEIEHRLLMNDNINEAIVVAKEDQENSKYLCAYIAFNNKNADIEQVQERLAKDLPEYMIPSCFIKLDQIPRTINGKADLKALPEPDRRAFAQARYEAPRNQTEALLLSIWQDILPAEQIGINDHFFDIGGHSLKAFSMAAKIQSALKVEVTLKEIFNHSTIQDLAAYIAQKQKQVQSDIQKAEKKEYYPLSSAQKRLYILNQIEEGQTAYNMPFAMKIKGELQTDKAEKAFRTLIKRHESSRTSFVTINGEPVQNINEEVTFEMKYRELDNCSLRERMNQFIRPFELEKAPLLRAELVRVNAAEHILLLDMHHIISDGVSIGILMKEWAALYEEKELAPLKIQYKDYSEWQRDPWQKDRLKKQEESWLSVFQNDIPVLNMPTDFPRPQMQSYEGDRIAFAIERELTDKLKKTAKENGVTMYMLLLAGYTILLSKYTGQEDIIVGSPIAGRTREELEQTVGMFVGTLAMRNHPKGGRTFIEYLQDVKENTFNAYENQDYPFDELVDKLDLERDISRNALFDTMFDMQALDDAEPDIEGLHVEPVDLEFQISKFDLSLTAAESAGVITFHLEFCTRLYKKETAETLAQHFVNILRDISDHPQKTLNDISMLSEEERHTVLYQFNDTNTEHPSGIFSELFEEQAEKSPNHPAAVFKDQMLTYRELNEKANQLARTLRQKGVQRESVVGIMAERSLEMLTGILAVLKAGGAYMPIDPGLPKERIQYLITDSGADLLLTQHQLIGSISFAGEIIQIDQADAYDTDGSNLEHLNSPGDLAYVIYTSGTTGNPKGVMVEHRNIIHAHYTWRKHYELASFSVNLLQLASMSFDVFAGDLCRSLLNGGTMYIVPDDVKLEMNLLYDMINKYGIHMLESTPSLIIPLMKYIDHHKLDFSSMKLLIMGSDTCTIKDYKWLVERFGQRMRIINSYGVTEASVDSGYYEEALDRIPEIANTPIGKPLDNTAFYILDPSLNPQPVGVYGELYIGGEGIARGYLNKPELTKERFVPNRFAAGGNMYKTGDLARWLPDGNVEFLGRIDHQVKIRGFRIETGEIETKLLENQNISEAVVIDREDKKGHKYLCAYIVARAKTNTNELREYLSDHLPDYMLPSYFIQINKMPLTPNGKIDRKALPEPAGDVIAASGYEAPRNETEEKLAAVWQEVLDRDKIGINDNFFEIGGDSIKALQIVSKLSRADLKLQVKDLFTNPFIRHLSKYVKKETKARTSEIVQGQVPLTPVQRSFFEANQREQNHYNQAFMLYRENGFAERIVEKVFRKLTEHHDALRMVYWEKNGDIIQHNRGLEDSVFDLYVYDLKTEKNLEKTVYQIATNIQKDISISEGKMIKLCVFKTTEGDHLLIAIHHLLVDGVSWRILFEDFEAAYGQALQGKPIELGYKTDSYKTFSEKLAEYANSKKLLKEQEYWREISKGKMAFLPKHRQAAHDNYENSRTLRISLSQTETEQLLKEAHKAYNTQINDLLLTALLIASRQLTGENRLKILMEGHGRDDILQDVDITRTVGWFTAMYPVFIDLEDEADLSVMIKIVKETLRKIPNNGIGYGILKYLRKDEGLLKDEKPPILFNYLGELDHDLTTEQFSSSKLSAGQSIGEKSARDASVEIDSVVAGRQLMISTTFNEYEYSPDTISELNQAFKESLQMVISHCTGKHETEKTSSDYGYDKLSLEDLEELLNEYESVDS

Gene
bacB
Protein
H2HPP isomerase
Organism
Bacillus amyloliquefaciens
Length
236 amino acids
Function
Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacB catalyzes the allylic isomerization of the endocyclic-delta(4),delta(8)-7R-dihydro-hydroxyphenylpyruvate (en-H2HPP) to generate a mixture of 3E,7R- and 3Z, 7R-olefins of the exocyclic-delta(3),delta(5)-dihydro-hydroxyphenylpyruvate (ex-H2HPP).
Mass
26.794 kDa
Sequence
MKTKQDLQELYFPTPKLIEWENGVRQYSSVRGDTEVLLSYVPPHTNVEPHQHKEVQIGLVVSGELSMTVGDVTRKMTALESAYIAPPYVPHGARNETDQEVIAIDIKRLKAGETYTSPEDYFLNIFKTRDLLPGMEVTFFVEDWVEIMLANIPGNGGEMPFHKHRNEQIGICIGGGYDMTIEGCKVDMTFGTAYFCDPREDHGAINRFEKDSKSVNIFFPPRYNRAKAKKLEAKES

Gene
bacB
Protein
H2HPP isomerase
Organism
Bacillus subtilis
Length
236 amino acids
Function
Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacB catalyzes the allylic isomerization of the endocyclic-delta(4),delta(8)-7R-dihydro-hydroxyphenylpyruvate (en-H2HPP) to generate a mixture of 3E,7R- and 3Z, 7R-olefins of the exocyclic-delta(3),delta(5)-dihydro-hydroxyphenylpyruvate (ex-H2HPP).
Mass
26.732 kDa
Sequence
MKTEQDLQELYFPTPKLIEWDNGVRQYSSVRGDTEVLLSYVPPHTNVEPHQHKEVQIGLVVSGELSMTVGDVTRKMTALESAYIAPPNVPHGARNETDQEVIAIDIKRLKAGETYTSPEDYFLNIFKTRDLLPGMEVTFFVEDWVEIMLANIPGNGGEMPFHKHRNEQIGICIGGGYDMTIEGCKVDMTFGTAYFCDPREDHGAINRFEKDSKSVNIFFPPRYNRAKAKKLEAKES

Gene
bacB
Protein
H2HPP isomerase
Organism
Bacillus subtilis (strain 168)
Length
235 amino acids
Function
Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase (PubMed:15609023, PubMed:20052993). BacB catalyzes the allylic isomerization of the endocyclic-delta(4),delta(8)-7R-dihydro-hydroxyphenylpyruvate (en-H2HPP) to generate a mixture of 3E,7R- and 3Z, 7R-olefins (E/Z ration of 3/1) of the exocyclic-delta(3),delta(5)-dihydro-hydroxyphenylpyruvate (ex-H2HPP) (PubMed:20052993, PubMed:22483065, PubMed:22765234, PubMed:19776011).
Mass
26.84 kDa
Sequence
MKTKEDMQELYFPTPKLIEWENGVRQYSTVRGDTEVLMSYVPPHTNVEPHQHKEVQIGMVVSGELMMTVGDVTRKMTALESAYIAPPHVPHGARNDTDQEVIAIDIKRLKADETYTSPEDYFLDIFKTRDLLPGMEVTFFVEDWVEIMLAKIPGNGGEMPFHKHRNEQIGICIGGGYDMTVEGCTVEMKFGTAYFCEPREDHGAINRSEKESKSINIFFPPRYNRAKAKKMKADE