Protein
3-hydroxy-5-methyl-1-naphthoate 3-O-methyltransferase
Organism
Streptomyces sahachiroi
Function
O-methyltransferase that mediates the formation of 3-methoxy-5-methyl-1-naphthoate from 3-hydroxy-5-methyl-1-naphthoate in the biosynthesis of the antitumor antibiotic azinomycin B.
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Sequence
MAAGSGSGTPPGTPPPTLLTDLATGLWKTQTLTAAIETGLFEALAAGDADAPETAQRLGIGKRPAEILLTACTALGLLEQRDGRYRNTAVAAHYLVPGLPDYFGGYVQMVARYTAPGWLRATEAVRTDAPTKPVPDPDRNMFEEGNRPESFWEGLFTFSTLTARQLAASVDLSGVRRIMDVGGGAGATLIELCRQHPHLSGTVVDLPHVCALAGERIAAAGMTGRIDTAAADFFADPLPSGHDAVLLSMILHDWDESQNRKILASCLDALPSGGTVLISELLVDDDKSGPVDAALMSMNMLVGTWGRNYTGAEYTDWLRDAGCSEVRTVRFASPGANGVVAGVKA