Protein
5-methyl-1-naphthoate 3-hydroxylase
Organism
Streptomyces sahachiroi
Function
Hydroxylase that catalyzes the C3 regiospecific hydroxylation on the 5-methyl-1-naphthoate to 3-hydroxy-5-methyl-1-naphthoate in the biosynthesis of the antitumor antibiotic azinomycin B.
Similarity
Belongs to the cytochrome P450 family.
Sequence
MTTEAADATDRLVTAFDHHDPGYTPRTAERINTEIRERGVTWSPAYGGIWILSRYADVRAALTDWRTYSSARGVHFPRAEGMPMFSPIDYDPPAQRGIRERMAAPMTGDAVSAMVPELRRMVARLLAPLAGRGHGDLMAEFAEPFAIEVLGVAFGLSESCRARIREATRTMWTYISADRDASKFWPAFHALLAEEVERVRDEPDGSYLARLAAMRRDGSPLPDEELYSIIVSFCVAGHDNTMNSITRLVHTLAQDPALQLRLRREPELRPAVAEEALRRWCPTDRFTRVTTREVTVAGTVIPAGARVVLLFDAANRDPEKFPDPDTFDPDRGNSHQHLSFGHGIHHCMGVHLARAEFAAVLDELSRLPLFDLEQPSDLHFENGRHIMFDRVSVRFRTGEEH