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aurka-b

Gene
aurka-b
Protein
Aurora kinase A-B
Organism
Xenopus laevis
Length
408 amino acids
Function
Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Phosphorylates numerous target proteins. Important for microtubule formation and/or stabilization (By similarity).
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
Mass
46.477 kDa
Sequence
MERAVKENHKPSNVKVFHPMTEGPKRIPVSQPPSTQVRPPVTGVSAQRILGPSNVPQRVMMQAQKPVLSNQKPTAQGLLRPATHGHQTSKPQGPNENRNPQQTSHSSTPNMEKKGSTDQGKTLAVPKEEGKKKQWCLEDFEIGRPLGKGKFGNVYLARERESKFILALKVLFKSQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDACRVYLILDYAPGGELFRELQKCTRFDDQRSALYIKQLAEALLYCHSKKVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFETDTHQETYRRISKVEFQYPPYVSEEAKDLVSKLLKHNPNHRLPLKGVLEHPWIVKNSQQPKKKDEPLAGAQ