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aurS

Gene
aurS
Protein
Aurofusarin biosynthesis cluster protein S
Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084)
Length
407 amino acids
Function
Part of the gene cluster that mediates the biosynthesis of aurofusarin, a red mycelium pigment which is acting as a mycotoxin (PubMed:15811992, PubMed:15809006, PubMed:16879655). The first step is performed by the polyketide synthase which condenses one acetyl-CoA and 6 malonyl-CoA units to form the first intermediate, the cyclic heptaketide and yellow pigment YWA1 (PubMed:21296881, PubMed:23557488). The C2 hydroxyl group in the pyrone ring of YWA1 is probably formed during ring closure by an aldol-type cyclization reaction (PubMed:21296881). The dehydratase aurZ then acts as the first tailoring enzyme in the aurofusarin biosynthetic pathway by converting YWA1 to nor-rubrofusarin (PubMed:21296881, PubMed:23557488). Nor-rubrofusarin is then methylated to rubrofusarin by the O-methyltransferase aurJ (PubMed:21296881, PubMed:23557488). Rubrofusarin is then transported across the plasma membrane by the rubrofusarin-specific pump aurT for further enzymatic processing by the extracellular complex composed of GIP1, aurF, aurO and aurS to yield aurofusarin (PubMed:21296881).
Mass
45.574 kDa
Sequence
MSKQKPSLWRALRALSFIISIPLLIQYLVLKWYSTSQNTPTPVFHEPNHETNLTVWEVLSNDDRVSKFVDVIGKLPDIVRGLSAPQARFTVYAPVNEAFDSFYFPPDPPPFFGLFIAGCHMGPGPVPAERLPSMGTVSSFVNGDIFFTYKQRISVQKDKSGLTLNRAARVLPVNASQSIAVNGFVHHIDTVLELPNSTAHALRTRPELSKLRRGLEATKLSESIYDTNAHVSQTIFAPTNAAFDRLGKTATKFLFSHGGRPYLRALLKYHVVANKTLFSDSYWPHGGAKLMDLSLIPNKDSHQFDLPTLHNNLTLQVESRKIHKKWHLNVLKDQVAEGKSHDSIPVSMPDVILMDGVMHFIDSILLPPAKSEQRKTSWLSRLKSSLGHNKQSIEDLVTLLGPYIDEP