Function
Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (By similarity). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion (PubMed:19052547, PubMed:20176933, PubMed:24120942, PubMed:25202121, PubMed:26083785, PubMed:26098762). Acts coordinately with lid-1 within the lipolytic cascade to distribute stored energy to tissues (PubMed:25202121). Together with lipid droplet protein cgi-58, regulates lipid reserves as well as lipid droplet size and localization during the dauer phase in response to phosphorylation by ampk (PubMed:19052547, PubMed:26083785, PubMed:26098762). May regulate serotonin-mediated lipolysis in metabolic tissues (PubMed:24120942).
Sequence
MTMINSRPELMNLSFSGCGFLCVYHAGVAAAIKEYAPELLQNKILGASAGSIVACGLITGVCISHATSTILKVVSQARSRTFGPLHPEFNLLGIVRDELEVILPPNAYEMCTGRLVISLTRWSDHENVIIDEYRSNADLIDAIMCSCFIPLYCGITPPKFRGVQYIDGGVSDNQPIYDEHTVTVSPFSGESDICPPDWDSGSMLGVDFNGTSIRFTTRNMFRLMACLWPRSTDDLSRMCLQGFGDALRFLTKCGLAPCIRCLTIQTIDANEPAGRVSSECFSENDDAKKVTHVAVPRMKKRASANALNSFRTRGESECETCGDSDIPLEEVNIQSFFPSIMKKPFEDAVAAERSVFQYMMSFRLVRYATTAMGISKFPFDMALAFVKKVHQYLDMVSPPRWIMLKFRGLADFILGEVEKQKSRYTNFSCLVAVAETDSFGSVLASSTMEKEEHKEIELSEDAKKEMILLRERDRRRKLLKKAGKITPNNSENQFDETSVYDVDSFEHVIDFTKSHEALYEFHYRDENQVMKTFGLFTDSQQRPYSSASQHQHHHTKSLGGTSRLVHVPEEDEDAPLSAVSAPAVIFHGGQEIVELGESDKDSGLSGIDTKRKVPDEPTTRF