Protein
Autophagy-related protein 2
Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084)
Function
Required for cytoplasm to vacuole transport (Cvt) vesicle and autophagosome completion (By similarity). Necessary for the localization of ATG18 to the preautophagosomal structure (PAS) and the binding of ATG18 to ATG9 (By similarity). Involved in correct ATG9 trafficking through the preautophagosomal structure and in peroxisome degradation (By similarity). ATG2 is the most downstream ATG protein in the preautophagosomal structure organization process (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).
Similarity
Belongs to the ATG2 family.
Sequence
MATFFQSFRSSSMPKRLLRYALSRLELLDADALEMDNLDLAIGRNTVFEFRDVGIKLKKLNKLLQLPDTFKLKKAKVLLLRVTIPMDFYTSPIIVEVDGVDIALQVIGNESKPSRSPGTRTPDESVAVPNTVDLAQSFLETQPKSERRKLEDALAAESQDLGASVSMSDDGSEDDLAYGTGQALSLPAFLADFLQGIVDRMQVRIKGVNFQLDVEVLVEPSSTTNEMVSFQVALEGIDVEGVTTRSYDDAGFPTIVHKEGKRHVSLSNVRAYLISEANVFSALAKSPSIASPSLASSPAMTRNPPSRQATELSLASLRDEPVSSSQASIRSNEPESASHHSLPENDHILSSQHSIDQRLESSLRQSLQRKDPLADSHESLQDDYFMDQEPVEQDYPLGDSEDALGIPYEFSNPQDDDAEDSPATPRASMYHDFNNAANDETLFHSILLPGEHGSQSTVLENERSMWSTPEREARSAPNLETPVAQFNMEASSSSIQNEQLRRTFSSESFGVASTEELAQSHMYTHEDAENEPAPEVEQTTEPEKPDSPVLDTSVHELARPQTPEPELSIAEAPVPETSSPKALSLRAPSPVTEDAPSPVREHRKPEGFIPGAWDDDYDDPEEEPVASTTLRRSAYRSKILSDPADASDSESSEPAFSRACLTDIDPENPRASTKQQEDVATPKGPTRLVKEILNLKTISIYIPSQHQHIQVQPASSESVAELSQSLGQSAYPQAPGAFSVHGATHAQQRSSQGTSSVENSLEVDLSPINLRFDASLGFLLAMVVGKLLEAVKDKKPSPAEGSKQDTASKDAPSKETPNVKVTFEEIKLDFVNRLGGISDTPERYLDPSAFIFDQEVLLNATLQNLAISITQTEISTTPVTKGRLTTQPAVLTRIDLQKFRFGYANGDIISFDSGKPMSTSVRDTFLSDGTDIGIKILQSGGNTKTEVQTLPLVFQLDLRRLDETFSWFGGLSSFLNMSASIASSPAPTPKPAAVVQKPRGVRFDTPVDPDDKSAASENKINLRIGGSWVELIGKDCSMIAETSAIKLISRDEVIGMACSMMRVSGPHLKNSAAEPPINTEIGGVRVEFLTTPKDTDLEKLLELIMPSKHQFDGENDEIMVDTLLRQRRKGSVLRVTVDTVSVRVQNMPLLSVLPNLGEEVAKLSTVAKYLPEDDRPGLLTLGKIRKVGLSLDFGGKLGHLGTDIQDLHVGHISIPSLVAIALHDISVQRNRSEELVSTSPYGARDISLRSPVLMARMIGDEIEPVIKLKMQDLCIEYRVPTIMDLLELGEDATPQDFEASLAASVANLGDQAHHVLTGAPGSPGGKAKSGKPMTLDIGFRDCLLGLNPLGQPSKMVIALTDAHLVALLPQDVETNAVFTINKSSILLINDVAEVKMNELPATQRSRASSSTSRQVSDMCARGYVDICYISSAKVTVDVKELEDGEKQLVVELKDDLLVLETCADSMQTLVSLANALKPPTPPSKENKYLTDVVPMQDLLASISAEAFGRPEGEYDFDQDFAGAQEMAGSGSEADYNTDSPLQVQSRYYDEPVAEELFDATSSSIISRGSQRSGPMMQDTNEGVLLTGFEPTSQQSIDSDDLVIHDDYYDQGASKDSKAKVWNSMKNSYDLAPSDLVKRSILRVKVRDVHVIWNLFDGYDWVHTRDVITKAVQDVEAKAYERQARAGQVHVYEEELEDEEAIGDFLFNSIYIGIPANRDPQELSRAINEGFNDGATETESVATTAFTSATNRTARARPRSKRLKLKRSKHHKITFELQGVDADLFVFPPNSGETLNSIDVRIKTLDVFDHVPTSTWKKFATYDQDMGEREMGTSMVHLEMLNVKPQPSLEASEIVLRATILPLRLHVDQDALDFITRFFEFKDDQVPVHTSKSDVPFLQRAEINNISVKLDFKPKRVDYAGLRSGHTTEFMNFIVLEEARMVLRHVIIYGISGFEKLGKTLNDIWTPDVKANQLPGILAGLAPVRSLVNVGSGFRDLVEVPIREYKKDGRVIRSISKGATAFARTTGTELVKLGAKLAVGTQYALQGAEGMLSGPQQVYEGWDDDDVDPDEQRQISLYADQPTGVISGIRGGYRSLARDVNLVRDAIIAVPGEVMESSTASGAARAVLKRAPTIIFRPAVGVTRAIGQTLMGATNSIDPNNRRRIEEVCYLFAILRRILLTAA