atg-13

Gene

atg-13

Protein

Autophagy-related protein 13 homolog

Organism

Caenorhabditis elegans

Length

443 amino acids

Function

Component of the unc-51/atg-13 complex required for autophagosome formation (PubMed:19377305, PubMed:26687600). Required for the degradation of germ cell specific P-granule components such as sepa-1 by autophagy in somatic cells (PubMed:19377305). This ensures exclusive localization of the P-granules in germ cells (PubMed:19377305). May function downstream of the let-363 (Tor) signaling pathway to mediate sepa-1 degradation (PubMed:19377305). Plays a role in survival during limited food availability (PubMed:19377305).

Similarity

Belongs to the ATG13 family. Metazoan subfamily.

Mass

49.8 kDa

Sequence

MVNEYDTYNKWLKFFSVRMVQSIIQSRLGDEIESKCVPYSENAVDWFNMRIDELGEISAYLKSNIKSYPPVGTLTLEFLLYTPSGQLLPLEAWILSSSEGTDDCSRNELYHDMSTLLRSAIVSARMTPMHRLYVKKQHLETFVIMYRVFENDISSDMGKGKKTRKIGELVSKFGNISLDLHYRTSMHFEEPEIAPVTPVEDVEEEIDDGEKTVVDENIQTRTVSECVPIADAKKRKASGSVESATSAGSSTSREAAPRFILGQSTSSEDSRHSDVQNSYEEDHKPSLADLRNHSFPFVNLLQSAYNPANGTKKNSSSTCLNSPKSTPEDKEPTIEKVAESFRAAKIDEVVFEEDEDEELPLDSMELSEDSFVHFNQLSDFGGAPSLGNELGDYLKQLKTAPDMTESGDIDICNMDLKTELEKISSQTANFNNFLKHVNSFSDE

Protein