Protein
Antibiotic efflux pump membrane transporter ArpB
Organism
Pseudomonas putida
Function
The inner membrane transporter component of an antibiotic efflux pump. Confers resistance to numerous structurally unrelated antibiotics such as carbenicillin, chloramphenicol, erythromycin, novobiocin, streptomycin and tetracycline. Is not involved in organic solvent efflux.
Similarity
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
Sequence
MSKFFIDRPIFAWVIALVIMLVGALSILKLPINQYPSIAPPAIAIAVTYPGASAQTVQDTVVQVIEQQLNGIDNLRYVSSESNSDGSMTITATFEQGTNPDTAQVQVQNKLNLATPLLPQEVQQQGIRVTKAVKNFLLVIGLVSEDGSMTKDDLANYIVSNMQDPISRTAGVGDFQVFGAQYAMRIWLDPAKLNKFQLTPVDVKTAVAAQNVQVSSGQLGGLPALPGTQLNATIIGKTRLQTAEQFESILLKVNKDGSQVRLGDVAQVGLGGENYAVSAQFNGKPASGLAVKLATGANALDTAKALRETIKGLEPFFPPGVKAVFPYDTTPVVTESISGVIHTLIEAVVLVFLVMYLFLQNFRATIITTMTVPVVLLGTFGILAAAGFSINTLTMFAMVLAIGLLVDDAIVVVENVERVMSEEGLPPKEATKRSMEQIQGALVGIALVLSAVLLPMAFFGGSTGVIYRQFSITIVSAMGLSVLVALIFTPALCATMLKPLKKGEHHTAKGGFFGWFNRNFDRSVNGYERSVGTILRNKVPFLLGYALIVVGMIWLFARIPTAFLPEEDQGVLFAQVQTPAGSSAERTQVVVDQMREYLLKDEADTVSSVFTVNGFNFAGRGQSSGMAFIMLKPWDERSKENSVFALAQRAQQHFFTFRDAMVFAFAPPAVLELGNATGFDVFLQDRGGVGHAKLMEARNQFLAKAAQSKILSAVRPNGLNDEPQYQLTIDDERASALGVTIADINNTLSIALGASYVNDFIDRGRVKKVYIQGEPSARMSPEDLQKWYVRNGAGEMVPFSSFAKGEWTYGSPKLSRYNGVEAMEILGAPAPGYSTGEAMAEVERIAGELPSGIGFSWTGMSYEEKLSGSQMPALFALSVLFVFLCLAALYESWSIPIAVVLVVPLGIIGALIATSLRGLSNDVYFLVGLLTTIGLAAKNAILIVEFAKELHEQGRSLYDAAIEACRMRLRPIIMTSLAFILGVVPLTIASGAGAGSQHAIGTGVIGGMISATVLAIFWVPLFFVAVSSLFGSKEPEKDVTPENPRYEAGQ