Arid3a

AT-rich interactive domain-containing protein 3A

601 amino acids

Transcription factor involved in B-cell differentiation. Binds a VH promoter proximal site necessary for induced mu-heavy-chain transcription. Binds the minor groove of a restricted ATC sequence that is sufficient for nuclear matrix association. This sequence motif is present in matrix-associating regions (MARS) proximal to the promoter and flanking E mu. Activates E mu-driven transcription by binding these sites. May be involved in the control of cell cycle progression by the RB1/E2F1 pathway.

64.173 kDa

MKLQAVMETLIQRQQRARQELEARQAPPPPPPEPTGVRARTTMTDEDREPENARMHRTQMAALAAMRAAAAGLGHPSSPGGSEDGPPISGDEDTAREGTLSSPALHGSVLEGAGHAEGDRHLMDVGSDDDDTKSKWEEQELEELGEEEEEEEEEDDFEEEEEEEEGLGPPESASLGTAGLFTRKAPPAQAFRGDGGPRMLSGPERLGPGPAHPSHMASQMPPPDHGDWTFEEQFKQLYELDADPKRKEFLDDLFSFMQKRGTPVNRIPIMAKQVLDLFMLYVLVTEKGGLVEVINKKLWREITKGLNLPTSITSAAFTLRTQYMKYLYPYECERRGLSSPNELQAAIDSNRREGRRQSFGGSLFAYSPSGAHSMLPSPKLPVTPLGLAASTNGSSITPAPKIKKEEDSAIPITVPGRLPVSLAGHPVVAAQAAAVQAAAAQAAVAAQAAALEQLREKLESTEPPEKKMALVADEQQRLMQRAVQQSFLAMTAQLPMNIRINSQASESRQDSAVSLTSANGSNSISMSVEMNGIVYTGVLFAQPPPPTAPSAPGKGGVSSIGTNTTTGSRTGASGSTVSGGQVGLPGVSTPTMSSTSNNSLP

ARID3A

AT-rich interactive domain-containing protein 3A

593 amino acids

Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation.

62.889 kDa

MKLQAVMETLLQRQQRARQELEARQQLPPDPPAAPPGRARAAPDEDREPESARMQRAQMAALAAMRAAAAGLGHPASPGGSEDGPPGSEEEDAAREGTPGSPGRGREGPGEEHFEDMASDEDMKPKWEEEEMEEDLGEDEEEEEEDYEDEEEEEDEEGLGPPGPASLGTTALFPRKAQPPQAFRGDGVPRVLGGQERPGPGPAHPGGAAHVAPQLQPPDHGDWTYEEQFKQLYELDGDPKRKEFLDDLFSFMQKRGTPVNRIPIMAKQVLDLFMLYVLVTEKGGLVEVINKKLWREITKGLNLPTSITSAAFTLRTQYMKYLYPYECEKRGLSNPNELQAAIDSNRREGRRQSFGGSLFAYSPGGAHGMLSSPKLPVSSLGLAASTNGSSITPAPKIKKEEDSAIPITVPGRLPVSLAGHPVVAAQAAAVQAAAAQAAVAAQAAALEQLREKLESAEPPEKKMALVADEQQRLMQRALQQNFLAMAAQLPMSIRINSQASESRQDSAVNLTGTNGSNSISMSVEINGIMYTGVLFAQPPAPTPTSAPNKGGGGGGGSSSNAGGRGGNTGTSGGQAGPAGLSTPSTSTSNNSLP

arid3a

AT-rich interactive domain-containing protein 3A

570 amino acids

Transcription factor.

62.395 kDa

MVDNTSIATKSALQAAFSSASSLPLLVSSPGAHGQSGGGGGMKLEAVMENLQRQQAARLALEEKLRQAEKEKDIRSMVESQIQQQALAFRHYQAAVRGAFAAGVPNSSSGHPLERRAESDIDDEDDEDDDPELDRGMDDEERDMDEDDSMNEGGGDEDLEGPLAHYPPRHAVYPGAGQSPKSTPIHLSRVQPPYPAPRQAESPSALAPQAQSQHHEWTYEEQFKQLYELDDDEKRKEFLDDLFSFMQKRGTPVNRIPIMAKQVLDLYTLYKLVTEKGGLVEVINKKIWREITKGLNLPTSITSAAFTLRTQYMKYLYPYECEKRGLSSPGELQAAIDSNRREGRRQSYGSTLFNYSPVGTPTLLASPKLQMPHISMPTPNGGHMTQTPGIKKEDSMLSSCLTNRVGIPMSLAGHHSAAQAAAAAAVQAAALEQLREKLESGEPPEKKVMLMAEEQQRIMQHALQQNLFAMATQLPMNIKLNNRDDRQETALNLSTNGISSINMSIEINGVVYTGVLFARKPAIGFMPSSQRVHHQHSSQGKSNSPGLSSHIQPSSSASSSASSHGPATSP

arid3a

AT-rich interactive domain-containing protein 3A

541 amino acids

Transcription factor required for smad1 and smad2-mediated responses to TGFbeta during mesoderm induction.

58.757 kDa

MKLQAVMETLQRQQRARLQQELEARQLQQDSSEGRTPPSVGYPGNGSEEAEPEALKIQRAQAAALAAMRAAAAGLSQQPSPAASDEEEEDGESMASDEEDEKERDGESERYPDMGSEEEDLKGKWDEDDFEDEGEEDDYEDMEEGMGVSEAGRVGKGSTLPPKHPNPQAFPTQRSVGAERAGLPHTGHPQLQDHGDWTYEEQFKQLYELDGDPKRKEFLDDLFSFMQKRGTPVNRIPIMAKQVLDLYMLYVLVTEKGGLVEVINKKLWREITKGLNLPTSITSAAFTLRTQYMKYLYPYECEKRGLSNPNELQAAIDSNRREGRRQSFGGSLFTYSPSGAPSMLSSPKLQVSALSLGGVATNGSSLSSMQKIKKEEDSPISLTVPPRIPVSLAGHSMVAAQVAAQAAALEQLREKLESGEPPEKKMALGTEEQQRLQRAIQHNLLAMTAQLPMNIRINSQAEGRQDSAVNLTTNGTNSISMSVELNGIVYTGVLFAQPPTSASGTSKGSSNRTGSIGGGSSTSQAAPPPAPSAPTSNNPSP

arid3a

AT-rich interactive domain-containing protein 3A

539 amino acids

Transcription factor required for smad1 and smad2-mediated responses to TGFbeta during mesoderm induction.

58.57 kDa

MKLQAVMETLQRQQRARLQQELEARQLQQDSSEGRTPPSAGYPGNGSDEAEPEALKIQRAQAAALAAMRAAAAGLSQQPSPAASEEEDGESMASDEEDEKERDGESERYQDMASEEEDLKGKWDEDDFEDEGEDEYEDMEEGIGVNEAGRVGKGSTLPPKHSSQQAFPSQRSQGAERAGLPLSGHPQLQDHGDWTYEEQFKQLYELDGDPKRKEFLDDLFSFMQKRGTPVNRIPIMAKQVLDLYMLYVLVTEKGGLVEVINKKLWREITKGLNLPTSITSAAFTLRTQYMKYLYPYECEKRGLSNPNELQAAIDSNRREGRRQSFGGTLFTYSPSGAPSMLSSPKLQVSGLSLGGAALNGSTLSSMQKIKKEEDSPISLAMPPRIPVTLAGHSMVAAQVAAQAAALEQLREKLESGEPPEKKMALGSEEQQRIIQRTIQHNLLAMTAQLPMNIRINSQAEGRQDSAVNLTTNGTNSISMSVELNGIVYTGVLFAQPPTSASGTSKGSSNRTGSIGGGSSNSQAAPPSTPSAPNSNNPSP