arfC

Gene

arfC

Protein

2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase

Organism

Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

Length

224 amino acids

Function

Catalyzes an early step in riboflavin biosynthesis, the NAD(P)H-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate. The beta anomer is the authentic substrate, and the alpha anomer can serve as substrate subsequent to spontaneous anomerization. NADPH and NADH function equally well as the reductants. Does not catalyze the reduction of 5-amino-6-(5-phospho-D-ribosylamino)uracil to 5-amino-6-(5-phospho-D-ribitylamino)uracil.

Similarity

Belongs to the HTP reductase family.

Mass

25.037 kDa

Sequence

MVMVMEKKPYIISNVGMTLDGKLATINNDSRISCEEDLIRVHKIRANVDGIMVGIGTVLKDDPRLTVHKIKSDRNPVRIVVDSKLRVPLNARVLNKDAKTIIATTEDTNEEKEKKIKILEDMGVEVVKCGRGKVDLKKLMDILYDKGIKSILLEGGGTLNWGMFKEGLVDEVSVYIAPKIFGGKEAPTYVDGEGFKTVDECVKLELKNFYRLGEGIVLEFKVKK

Protein

2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase: arfC

Gene

arfC

Protein

Uncharacterized membrane protein ArfC

Organism

Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

Length

175 amino acids

Function

Required for wild-type expression of ArfA and ammonia secretion.

Similarity

Belongs to the ArfC membrane protein family.

Mass

18.909 kDa

Sequence

MEHVHWWLAGLAFTLGMVLTSTLMVRPVEHQVLVKKSVRGSSAKSKPPTARKPAVKSGTKREESPTAKTKVATESAAEQIPVAGEPAAEPIPVAGEPAARIPVVPYAPYGPGSARAGADGSGPQGWLVKGRSDTRLYYTPEDPTYDPTVAQVWFQDEESAARAFFTPWRKSTRRT

Protein

Uncharacterized membrane protein ArfC: arfC

Gene

arfC

Protein

Uncharacterized membrane protein ArfC

Organism

Mycobacterium bovis (strain BCG / Pasteur 1173P2)

Length

175 amino acids

Function

Required for ammonia secretion (By similarity). Also required for wild-type expression of ArfA.

Similarity

Belongs to the ArfC membrane protein family.

Mass

18.909 kDa

Sequence

MEHVHWWLAGLAFTLGMVLTSTLMVRPVEHQVLVKKSVRGSSAKSKPPTARKPAVKSGTKREESPTAKTKVATESAAEQIPVAGEPAAEPIPVAGEPAARIPVVPYAPYGPGSARAGADGSGPQGWLVKGRSDTRLYYTPEDPTYDPTVAQVWFQDEESAARAFFTPWRKSTRRT

Protein

Uncharacterized membrane protein ArfC: arfC

Gene

arfC

Protein

Uncharacterized membrane protein ArfC

Organism

Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

Length

175 amino acids

Function

Required for wild-type expression of ArfA and ammonia secretion, not however part of an ammonia transporter.

Similarity

Belongs to the ArfC membrane protein family.

Mass

18.909 kDa

Sequence

MEHVHWWLAGLAFTLGMVLTSTLMVRPVEHQVLVKKSVRGSSAKSKPPTARKPAVKSGTKREESPTAKTKVATESAAEQIPVAGEPAAEPIPVAGEPAARIPVVPYAPYGPGSARAGADGSGPQGWLVKGRSDTRLYYTPEDPTYDPTVAQVWFQDEESAARAFFTPWRKSTRRT

Protein

Uncharacterized membrane protein ArfC: arfC

Gene

arfC

Protein

Uncharacterized membrane protein ArfC

Organism

Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Length

175 amino acids

Function

Required for wild-type expression of ArfA and ammonia secretion, not however part of an ammonia transporter.

Similarity

Belongs to the ArfC membrane protein family.

Mass

18.909 kDa

Sequence

MEHVHWWLAGLAFTLGMVLTSTLMVRPVEHQVLVKKSVRGSSAKSKPPTARKPAVKSGTKREESPTAKTKVATESAAEQIPVAGEPAAEPIPVAGEPAARIPVVPYAPYGPGSARAGADGSGPQGWLVKGRSDTRLYYTPEDPTYDPTVAQVWFQDEESAARAFFTPWRKSTRRT

Protein

Uncharacterized membrane protein ArfC: arfC