Protein
Autophagy-related protein 11
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion (By similarity).
Similarity
Belongs to the ATG11 family.
Sequence
MVTQVLIAHTGQRLEIDSRTITSLNGLKESVASQTSIPVECLIALTPQGRSLRWQPTQPETEIYIYDSRLTQRSQPGASSPPLSELPLPRYNAHTPPNSIEDTRSIPAWQKLFETRRAWAIDVVEDCARMDAATRERYAEMDVMLRCLDAAVANLENAVKGLENKYVELKEWSTSAQAEYSALATGFDRYLSLARGIAISSSMARFMTSRDDGGWKGRPQRQSTLEDLVDLELARQAGKLAPSALRKFKDRITNLDKAATHLFQDADTLMHKFETTMSRSALSHDGESLHLLKDIEALANKIDNDYNVTLEYTSSTRDTLLQVSKTAAHHTERLLPSIQKRALEMGDILCYATKARNSLAAESIEFMRSITEITSDSHSVKSQISETGQEDELATFDHLRLIQQIPYLYASFVAEAIRRREWLDKVKQDSTTLANEMAIFHEEEAKRRRRWHKSIGAVFGPAPTADSKVPNLEINLRGDDGEWPLMTRKDLDDFFNALRNQKADPELVVEIEKLIADMDKSTRQQSRRMKAFKNGSVHETALGRSGLLVRGDDDLLRSLQADKTRLESKLKTAESRVRRLEDLLHRQTQASRPNVGNLFQNPSQQVLDRNDSISSLRNPRAVDDRSRSLDGLETLIHRTQQLETELNTERERCVVLEREINALTTLHNDLKGQMDEANSTKKDLLQNMEALKREFTEERKSLEEEVKQLKARLEYTEDEIEHFGESRENEKASYDEKVHFLELEVERLTRERRDDSLKADDQVVLLQNEARLQRERIAAQDIELRAAQDEIRVLSKRLEAVTEDKQKYRQALEDIWECLAPADDVPTELPDLLEGITGKAADILNTKQGVEGDMSLMKLNVDTLQNNIRTLRSEMDFTKDRLTEEESVSLRLREKFSEERAKVVAMEGELAHGREQLHEFRVKIADGETGSEYMRKRLEDEEQNLASMTEELAAGQTQVQKMEEEVTRFKAKLHQTQMQLSELSIRLESRTECAKDLTQLLWSQNDRLTRLLERLGFSISREEDGTMHIQRTPRSERSLATTANPNDSDPSSSLRRSSTLNARPVTDNADLELLQWMSSATPEAEVEKYKIFMGLIGSLDMDVFADAVYRRVKDVEHMARKLQREARAYREKAHSFQKEAHDKIAFKHFKEGDLALFLPTRNQSTGAWAAFNVGFPHYFLREQDSHRLRNREWLVARIMRIQERVVDLSKSLQHDQAGETRKDGARGETESLDDDENDNPFDLSDGLRWYLIEAVEDKPGAPSTPGLAKSTVAANNVEAMADMRTQGHISKARGLTGRGGTPLGIEGVSKTLSKSLESRRSSTGSRKTLPFVIGASSRGRESALASETNSLRAVPADNNSSAPTNAAQQHMSPTDKLKDESLQETPQQTNSISAEGESMTIAARNDQAILQPSQTHSEVRNEIESLIGP