apg-1

Serine/threonine-protein kinase apg-1

968 amino acids

Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates. Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9.

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.

107.01 kDa

MSDRTSASSSSRRTKQNYDAIGSFVIDQEIGKGSFAKVYLGRHKVTGALVAVKSVELARLNKKLKENLYGEIQILKTLRHPHIVALHDCVESSTHINLIMEYCELGDLSLFIKKRDKLITNPYTHDLARKYPVYPNAGLNEVVTRHFLKQLASALQFLRAGDFVHRDVKPQNLLLLPSPHMMANNKTAKHIMSGSYDSFTPAAGLASAPMLKLADFGFARVLPSTSLAETLCGSPLYMAPEILRYEKYDAKADLWSVGTVLYEMVTGRPPFKASNHVELLRKIESSGDVIKFTRESVVSQEMKGLIRALLKKNPVERISFEDLFNHPVVTEPIPGLVEDDIPKPPRRRSLKEERPVSRAEDSLVPSRKQSLRKDLADREGAPQTAGPSSPKPRRSSPLATPNEPVEISKPNYFQIPPREDRLSYSPRKEAADGLGIKRPQVQPSTSAPTRPSSYVDRRHRSSNASLRAPVREANPPPNDVTRTKPRGMGTKPMTEEERAAQDIAFERDYVLVDKKHLEVNALADQISMYPQQPQSPKSAQIVRRATQQGSPTSTSGAVPSPPSRALQLAQGHSRQGSYDKALGTSPSKATSVISKAIQDASLRLFGFKYAPHLLSKGPSPVPMYNPFPTYPAPNTPTGLISDGKQGTPVDEDSRVAQCIEDHATRSDVVYGFAEVKYKQLVPLAPSMDHGLGGAPIEKSAEEDGLTAEAIVSLSEEALVLYVKALTLLAKSMDIASLWWSRKNKVESTNSITSAARDSANSEALALRINGAVQWIRSRFNEVLEKAEIVRLKLAEAQKRLPEDHPSHPNNHANDSTALNSLSTVGVFLSEGISAERLMYDRAIEMSRAAAINEIANEDLPGCEISYITAIRMLEAVLDQDDDHLPKRKVSGASKEEKTGANELSDEMNNEDKQVVQNVINMVNNRLTVLRKKLRLIESASKAQQQEEQKQQNLMRRRSGEMTSRSVPA