Function
Required for contractile events in embryos that occur prior to mitosis, such as cortical ruffling and pseudocleavage. Promotes membrane ruffling by organizing cortical patches of septins and myosin II. Not generally required for cytokinesis in mitotic cells. Required for the asymmetric cleavage events that extrude the two polar bodies during oocyte meiosis. Not required for meiotic contractile ring assembly, initiation or closure but is required for the transformation of the contractile ring from a disk above the spindle to a tube around the spindle midzone. Promotes astral microtubule-directed cortical myosin polarization and cleavage furrow ingression. Regulates neuroblast cytokinesis during mid- to late-embryogenesis and is required for ventral enclosure.
Sequence
MGDQFDSLMERIRVRQAEMSGEGEVAKENGPVTSKITSVKQEVASPTKVFGSSSKCNDGPSTPVHFHPQEPKETTPNMKENAENSLNSFKDATVNESSSKKTSRFSMLAQEIDEYEYDYQSQYNKPKEAYMKGRSPRMSIGETRPAVLCTPAGAQAMKSPNVAVSSKSAPEIALGMSDFEARRIKFAQPIVNVNYLPNESSIFSGGSGSSVNDQSTVLGGSAEMMNVTTSSLSCGELSMNQHITHENTIINAQSCDNREAILRERQQVSNEEYGPHTFMRKKVPKEASSATSSSSSTTTLTTISGASGSTTSGISNAPQDSASTKTTTNTFTSSYLLTKTSNNNINALVSSSPKPFSKDIGRSMFSPVHFTPKSTSSPKTLSESIFSPSKSAAVEGSIATTRRLQFEEKLKKSSSANVTAPPAPTSAPVPTPRHVAPLAPTVAQQSHLTPNHRHAAQQKKHLFPVVGIVATAPIPVQTQWRGQSNTPVVQGARADEKTAGNEPPVGAGVGKLKNLKSRWEFSSATGTPIHPDATEDSLIATAIKMKESAIPKQLGHRSERKGPSASSLYSQGARSNTASPASKSTRYEQEEEDDVFEAPEFNDGGDVISEDGILQEEEEDTSKFIDNAFGFMEGSGAGTPSPYREPPLQRLEKNRPPAEVIEEETENEDESEPYEPEEEEDDDATTQFPVPERSRKSSSQLAYSVSFYRKIQRDRNEESSTVLAGPVISQISPSAPPMSSSLTSQQKLRQLTTGPANGARIVESAKDAHDRIKRAIQVEEQLVAQSKRAMILARDKPSFRGSREEFEAQWAMLRHVEKHRALLTEYDRLKRDGPRIIDGPRGTITVSQLSVNMARDYVSANIASSKKSDEVFYFAAILRYGEQVDVSKMVTSDGGLNRRGVLEFPVPLMLTGIPPDFRATVEIYGQRSMRESTSHEDKYKLKNSTFKAKTRNTFLGGGSTSSANQSLFVDPAASSSSTSSTTSNFNLLGTFSFDINCPGKHLYNMSHTVYPLEGITQMKVRKQAIDGADITYHGFLSMYQRTGEGLGSWTRYWCALENGEMKFWKQPEDEGTKGYTALMDLSTCCRSEGASVVEDICPFPNSFHIDVWAPKMDTSDPRGIERLRVMLAADTAQDLQTWLSLINSTSKQLCTWRNPIVNQ