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anapc7

Gene
ANAPC7
Protein
Anaphase-promoting complex subunit 7
Organism
Homo sapiens
Length
599 amino acids
Function
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Similarity
Belongs to the APC7 family.
Mass
66.855 kDa
Sequence
MDPGDAAILESSLRILYRLFESVLPPLPAALQSRMNVIDHVRDMAAAGLHSNVRLLSSLLLTMSNNNPELFSPPQKYQLLVYHADSLFHDKEYRNAVSKYTMALQQKKALSKTSKVRPSTGNSASTPQSQCLPSEIEVKYKMAECYTMLKQDKDAIAILDGIPSRQRTPKINMMLANLYKKAGQERPSVTSYKEVLRQCPLALDAILGLLSLSVKGAEVASMTMNVIQTVPNLDWLSVWIKAYAFVHTGDNSRAISTICSLEKKSLLRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVMANNVYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGIALLRNALANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDPNDQKSLEGMQKMEKEESPTDATQEEDVDDMEGSGEEGDLEGSDSEAAQWADQEQWFGMQ

Gene
anapc7
Protein
Anaphase-promoting complex subunit 7
Organism
Dictyostelium discoideum
Length
580 amino acids
Function
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.
Similarity
Belongs to the APC7 family.
Mass
66.851 kDa
Sequence
MIQQLPMVNVELMISNLRILVESKQFSSAEFLGNFVISVPNQQKTPHQNIISFSLFGDSLFGKNEFVRSLKYFKQSLDILFKVYNNPNNNNNNNNKQADFDNKQFEYELKYKISLCYIKINRNNLAISYLESIPFSSRGLDTHLTIARLYKDIGKEKSKECIISYKEVIKLCPLCLEAINSLKEMGENVDQVLIPSINKFQQKNNSFNSNNIIDLSWISLLSMSQYEMKRNQPEKSLILLKKVESKFSTNLYVLEKLALSYLYHDEPSIINTFNIFQKIRLLDPYYIGSMDIFCSLLKRRSLQFELNKVCNDLVASNPYCAETWTSVALFYFLKENVEKSLENVDRAISIKESHEFAHSLKGEILLSLDEPREALPSLERAFQLSKNILTARELVRCHLILNQMKEALVVAETINNLSPDYSKTMALLGMVLANQPEEREEARKILTKALTLSPHCTDTVLTLSKLNVVEGRFQEAIDILNSQLEYQETDLMHTEIAGVYLTKDYHEDAMIHYNSALEINPQYEPASRGIARLELIMKGIDPDQELDQENDDDDQEEGEGENDQEENDDDDNDDDDEYIS

Gene
Anapc7
Protein
Anaphase-promoting complex subunit 7
Organism
Mus musculus
Length
565 amino acids
Function
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
Similarity
Belongs to the APC7 family.
Mass
63.021 kDa
Sequence
MSVIDHVRDMAAAGLHSNVRLLSSLLLTMSNNNPELFSPSQKYQLLVYHADSLFHDKEYRNAVSKYAMALQQKKALSKTSKVRPSTGNSASTPQSQCLPSEIEVKYKMAECYTMLKLDKDAIAVLDGIPSRQRTPKINMMLANLYKKAGQERPSVTSYKEVLRQCPLALDAILGLLSLSVKGAEVASMTMNVIQTVPNLDWLSVWIKAYAFVHTGDNSRAINTICSLEKKSLLRDNVDLLGSLADLYFRAGDSKNSVLKFEQAQMLDPYLIRGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVMANNVYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLDKALAQRPDYVKAVVKKAELLSREQKYEDGIALLRNALANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDPNDQKSLEGMQKMEKEESPTDATQEEDVDDMEGSGEEGDLEGSDSEAAQWADQEQWFGMQ