Protein
5-aminolevulinate synthase, mitochondrial
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.
Similarity
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
Sequence
MDSVLRQSKAVCPFMKKATASSLRAMTTAARPAASPCGGAISKLQVLAHRCPVMGKAMAVQSARTGGRASAAPASFVHKAKLHTGRPREAQAVEGVFTGQKAGLPPHPPVKPTTATAANPSPAACTVSGNFGTKFNYEKFYENELEKKHKDKSYRYFNNINRLAKDFPRAHMATKEEKVAVWCANDYLGMGRNKHVLEAMHTTLDEYGAGAGGTRNISGHNKHAVELENSLAKLHATDAALVFSSCYVANDATLATLGSKLPDCVILSDSLNHASMIQGIRHSGAKKIIFKHNDVEDLEKKLAALPLHIPKIIAFESVYSMCGSIGPIEKFCDLAEKYGAITFNDEVHAVGMYGPHGAGVAEHLDWEAHQRGETKGTIADRIDIYSGTLGKAYGCVGGYIAGSAKLVDTIRSLAPGFIFTTTLPPAVMAGARAAIEYQMSYDGDRRLQQLHTRAVKEALADRDIPVIPNPSHIIPILVGNAELAKKASDKLLNDHQIYVQSINYPTVPVGQERLRITPTPGHTKQFRDHLVAALDSIWTELGIKRTSDWAAEGGFIGVGEAEAEPVAPLWTDEQLGIADAVAELRAQASDEKKGVINQLLESVALEQEREALNAAEEVADAAKAAAASA