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alt4

Gene
alt4
Protein
FAD-linked oxidoreductase alt4
Organism
Alternaria solani
Length
482 amino acids
Function
FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of alternapyrone derivatives (PubMed:16356847). Alternapyrone is a decaketide with octa-methylation from methionine on every C2 unit except the third unit (PubMed:16356847). All the domains in the polyketide synthase alt5 are apparently involved in alternapyrone synthesis, that is, the 8 CMeT, 7 KR, 7 DH, and 4 ER reactions in the 9 KS-mediated condensation steps required for alternapyrone synthesis (PubMed:16356847). the alternapyrone produced by alt5 might be intensively modified by cytochrome P450 monooxygenases alt1, alt2 and alt3 and FAD-dependent oxidoreductase alt4 present in the alt gene cluster (PubMed:16356847).
Similarity
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
Mass
55.503 kDa
Sequence
MDIQQGGNDLISLAATIRTELQQKLSSKARIHLPFDEDRTEFDKANLRFTQYERPTYLAIVDPVCEDDVIEAVKYARGKGIPFTPRGGHHSVTTTMGRFQNGICINMRPLNQMRWYAEKRHVTIGGGAITDEFVRFVHDLGMEVTFGAGLGRLQGKYGFLNDNMVSCKLVLADGSTVIASKDSHPDLFWALRGAGHNFGIALEATFQVYPQAHGGIHHTWDLEYTLDQCDEVFRTLNSVYESMPAELAIFILWLRQSSGRKHIILVNLVWSGPAAGADPYVQRFESLQPVLNSGRKSVPWPELPFSTYKEINKLFCNPEIWLRGPYKMMGAACVERFDLKTTREFFESVKSLSEEWEDRGWFSAMFECLPDQRVREISDDATAFPWRAGSNHFLMLNATPKRMEDRKVFEDHLNYWKRRFIETSGYGRLQQYVSYGNGTSTMKDPPEALYGYEPWRLEKLRNLKQKYDPDNVFRWYQPLLEP

Gene
ALT4
Protein
Acyl-acyl carrier protein thioesterase ATL4, chloroplastic
Organism
Arabidopsis thaliana
Length
188 amino acids
Function
Acyl-ACP thioesterase involved in the production of fatty acids and beta-keto fatty acids. Can produce fatty acids of medium to long chain (6:0, 8:0, 10:0 and 16:1) and small amounts of medium to long chain beta-keto fatty acids (8:0, 14:0 and 16:1) when expressed in a heterologous organism (E.coli). Possesses thioesterase activity for lauroyl-ACP (12:0-ACP) in vitro. May play a role in the development of floral organs by generating short chain fatty acids.
Similarity
Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.
Mass
21.318 kDa
Sequence
MIRVTGTAAPAMSVVFPTSWRQPVMLPLRSAKTFKPHTFLDLKGGKEMSEFHEVELKVRDYELDQFGVVNNAVYANYCQHGMHEFLESIGINCDEVARSGEALAISELTMNFLAPLRSGDKFVVKVNISRTSAARIYFDHSILKLPNQEVILEAKATVVWLDNKHRPVRIPSSIRSKFVHFLRQNDTV