Alpha

Putative P4-specific DNA primase

777 amino acids

This protein acts as a DNA primase generating di- to pentaribonucleotides; the predominant product being the dimer pppApG. It complexes specifically to the P4 origin of replication (ori) and its cis replication region (crr). It also acts as a DNA helicase.

84.919 kDa

MKMNVTATVSHALGHWPRILPALGIQVLKNRHQPCPVCGGSDRFRFDDREGRGTWYCNQCGAGDGLKLVEKVFGVSPSDAAAKVAAVTGSLPPADPAVTTAAVDETDAARKNAAALAQTLMAKTRTGTGNAYLTRKGFPGRECRMLTGTHRAGGVSWRAGDLVVPLYDDSGELVNLQLISADGRKRTLKGGQVRGTCHTLEGQNQAGKRLWIAEGYATALTVHHLTGETVMVALSSVNLLSLASLARQKHPACQIVLAADRDLSGDGQKKAAAAADACEGVVALPPVFGDWNDAFTQYGGEATRKAIYDAIRPPAESPFDTMSEAEFSAMSTSEKAMRIYEHYGEALAVDANGQLLSRYENGVWKVLPPQDFARDVAGLFQRLRAPFSSGKVASVVDTLKLIIPQQEAPSRRLIGFRNGVLDTQNGTFHPHSPSHWMRTLCDVDFTPPVDGETLETHAPAFWRWLDRAAGGRAEKRDVILAALFMVLANRYDWQLFLEVTGPGGSGKSIMAEIATLLAGEDNATSATIETLESPRERAALTGFSLIRLPDQEKWSGDGAGLKAITGGDAVSVDPKYRDAYSTHIPAVILAVNNNPMRFTDRSGGVSRRRVIIHFPEQIAPQERDPQLKDKITRELAVIVRHLMQKFSDPMLARSLLQSQQNSDEALNIKRDADPTFDFIGYLETLPQTSGMYMGNASIIPRNYRKYLYHAYLAYMEANGYRNVLSLKMFGLGLPVMLKEYGLNYEKRHTKQGIQTNLTLKEESYGDWLPKCDDPTTA

alpha

Capsid protein alpha

407 amino acids

Peptide gamma: membrane-permeabilizing peptide produced by virus maturation, thereby creating the infectious virion. After endocytosis into the host cell, peptide gamma is probably exposed in endosomes, where it permeabilizes the endosomal membrane, facilitating translocation of viral capsid or RNA into the cytoplasm (Probable).

Belongs to the peptidase A6 family.

43.71 kDa

MVNNNRPRRQRAQRVVVTTTQTAPVPQQNVPRNGRRRRNRTRRNRRRVRGMNMAALTRLSQPGLAFLKCAFAPPDFNTDPGKGIPDRFEGKVVSRKDVLNQSISFTAGQDTFILIAPTPGVAYWSASVPAGTFPTSATTFNPVNYPGFTSMFGTTSTSRSDQVSSFRYASMNVGIYPTSNLMQFAGSITVWKCPVKLSTVQFPVATDPATSSLVHTLVGLDGVLAVGPDNFSESFIKGVFSQSACNEPDFEFNDILEGIQTLPPANVSLGSTGQPFTMDSGAEATSGVVGWGNMDTIVIRVSAPEGAVNSAILKAWSCIEYRPNPNAMLYQFGHDSPPLDEVALQEYRTVARSLPVAVIAAQNASMWERVKSIIKSSLAAASNIPGPIGVAASGISGLSALFEGFGF

alpha

Capsid protein alpha

407 amino acids

Peptide gamma is a membrane-disrupting peptide produced by virus maturation, thereby creating the infectious virion. After penetration into the host cell, peptide gamma is probably exposed/released in endosomes, where it disrupts the endosomal membrane, facilitating translocation of viral RNA into the cytoplasm (By similarity).

Belongs to the peptidase A6 family.

43.838 kDa

MVRNNNRRRQRTQRIVTTTTQTAPVPQQNVPKQPRRRRNRARRNRRQGRAMNMGALTRLSQPGLAFLKCAFAPPDFNTDPGKGIPDRFEGKVVTRKDVLNQSINFTANRDTFILIAPTPGVAYWVADVPAGTFPISTTTFNAVNFPGFNSMFGNAAASRSDQVSSFRYASMNVGIYPTSNLMQFAGSITVWKCPVKLSNVQFPVATTPATSALVHTLVGLDGVLAVGPDNFSESFIKGVFSQSVCNEPDFEFSDILEGIQTLPPANVTVATSGQPFNLAAGAEAVSGIVGWGNMDTIVIRVSAPTGAVNSAILKTWACLEYRPNPNAMLYQFGHDSPPCDEVALQEYRTVARSLPVAVIAAQNASMWERVKSIIKSSLAMASNVPGPIGIAASGLSGLSALFEGFGF

alpha

Capsid protein alpha

403 amino acids

Peptide gamma: membrane-permeabilizing peptide produced by virus maturation, thereby creating the infectious virion. After endocytosis into the host cell, peptide gamma is probably exposed in endosomes, where it permeabilizes the endosomal membrane, facilitating translocation of viral capsid or RNA into the cytoplasm (By similarity).

Belongs to the peptidase A6 family.

43.357 kDa

MTPRRQQRPKGQLAKAKQAKQPLARSRRPRRRRRAAITQNNLMMLSEPGLSFLKCAFASPDSNTDPGKGIPDNFEGKVLSQKNVYTETGVNFSGATTQNVDTYIIVLPTPGVAFWRCIKTATAPAQPAALTTTDVFTAVPFPDFTSLFGTTATNRADQVAAFRYASMNFGLYPTCNSTQYNGGISVWKGAVQMSTTQYPLDTTPESSQLVHAITGLESALKVGDENYSESFIDGVFTQSINGNAEFPFYPILEGVQTLPGQNVTVAQAGMPFSLDAGAATVAGFTGIGGMDAIFIKVTAAAGSVNTATIKTWACIEYRPNTNTALYKYAHDSPAEDIIALQQYRKVYKSLPVAVRAKLNANMWERVKRLLKAGLVAASYVPGPVGGIATGVQHIGDLIAELSF

alpha

Capsid protein alpha

401 amino acids

Peptide gamma: membrane-permeabilizing peptide produced by virus maturation, thereby creating the infectious virion. After endocytosis into the host cell, peptide gamma is probably exposed in endosomes, where it permeabilizes the endosomal membrane, facilitating translocation of viral capsid or RNA into the cytoplasm (By similarity).

Belongs to the peptidase A6 family.

43.326 kDa

MVSRTKNRRNKARKVVSRSTALVPMAPASQRTGPAPRKPRKRNQALVRNPRLTDAGLAFLKCAFAAPDFSVDPGKGIPDNFHGRTLAIKDCNTTSVVFTPNTDTYIVVAPVPGFAYFRAEVAVGAQPTTFVGVPYPTYATNFGAGSQNGLPAVNNYSKFRYASMACGLYPTSNMMQFSGSVQVWRVDLNLSEAVNPAVTAITPAPGVFANFVDKRINGLRGIRPLAPRDNYSGNFIDGAYTFAFDKSTDFEWCDFVRSLEFSESNVLGAATAMKLLAPGGGTDTTLTGLGNVNTLVYKISTPTGAVNTAILRTWNCIELQPYTDSALFQFSGVSPPFDPLALECYHNLKMRFPVAVSSRENSKFWEGVLRVLNQISGTLSVIPGPVGTISAGVHQLTGMYM

alpha

Capsid protein alpha

399 amino acids

Peptide gamma: membrane-permeabilizing peptide produced by virus maturation, thereby creating the infectious virion. After endocytosis into the host cell, peptide gamma is probably exposed in endosomes, where it permeabilizes the endosomal membrane, facilitating translocation of viral capsid or RNA into the cytoplasm (By similarity).

Belongs to the peptidase A6 family.

43.067 kDa

MVSKAARRRRAAPRQQQRQQSNRASNQPRRRRARRTRRQQRMAATNNMLKMSAPGLDFLKCAFASPDFSTDPGKGIPDKFQGLVLPKKHCLTQSITFTPGKQTMLLVAPIPGIACLKAEANVGASFSGVPLASVEFPGFDQLFGTSATDTAANVTAFRYASMAAGVYPTSNLMQFAGSIQVYKIPLKQVLNSYSQTVATVPPTNLAQNTIAIDGLEALDALPNNNYSGSFIEGCYSQSVCNEPEFEFHPIMEGYASVPPANVTNAQASMFTNLTFSGARYTGLGDMDAIAILVTTPTGAVNTAVLKVWACVEYRPNPNSTLYEFARESPANDEYALAAYRKIARDIPIAVACKDNATFWERVRSILKSGLNFASTIPGPVGVAATGIKGIIETIGSLWV

alpha

Capsid protein alpha

340 amino acids

Capsid protein alpha self-assembles to form an icosahedral procapsid with a T=3 symmetry, about 30 nm in diameter, and consisting of 60 capsid proteins trimers. The capsid encapsulates the two genomic RNAs (By similarity).

Belongs to the peptidase A6 family.

37.195 kDa

MVRKGDKKLAKPPTTKAANSQPRRRATQRRRSGRADAPLAKASTITGFGRATNDVHISGMSRIAQAVVPAGTGTDGKIVVDSTIVPELLPRLGHAARIFQRYAVETLEFEIQPMCPANTGGGYVAGFLPDPTDNDHTFDALQATRGAVVAKWWESRTVRPQYTRTLLWTSTGKEQRLTSPGRLVLLCVGSNTDVVNVSVMCRWSVRLSVPSLETPEDTTAPITTQAPLHNDSINNGYTGFRSILLGATQLDLAPANAVFVTDKPLPIDYNLGVGDVDRAVYWHLRKKAGDTQVPAGYFDWGLWDDFNKTFTVGAPYYSDQQPRQILLPAGTLFTRVDSEN

alpha

Protein alpha-2

116 amino acids

14.18 kDa

MFGYMEISVRVEIGKQNSRIHKLELWKLMEEGLHTLMKEEKLDIMLKEEANFGFCRWLNTRGNWLYLEDMRKPILIEFQNFFNCLNYPSRVYKLTVQNNDYKLGSIRDLRIKLFFF

alpha

Protein alpha-1

88 amino acids

10.694 kDa

MEKGLLSNFWNDFKRWSEDRKVEIVIWWSNLESKVRLGFWIILIILLGILAIRIAIKVYQCVKFTNQGVKKIKRIIKRKRSIKKYRKT

alpha

Protein alpha-3

51 amino acids

5.723 kDa

MEIDGRRFAHLDEGRKTGHNVKGGGKFRLLPMAQHQRELVVSGGHEKTNIN