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alb1

Gene
alb1
Protein
Conidial pigment polyketide synthase alb1
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Length
2146 amino acids
Function
Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of dihydroxynaphthalene (DHN)-melanin, a bluish-green pigment and a structural component of the conidial wall (PubMed:9620950, PubMed:10515939, PubMed:18539819, PubMed:19156203). The first step of the pathway is the production of the heptaketide naphtopyrone YWA1 by the polyketide synthase alb1 though condensation of acetyl-CoA with malonyl-CoA (PubMed:9620950, PubMed:11040426). The naphtopyrone YWA1 is then converted to the pentaketide 1,3,6,8-tetrahydroxynaphthalene (1,3,6,8-THN) by the heptaketide hydrolyase ayg1 though chain-length shortening (PubMed:10515939, PubMed:11350964). 1,3,6,8-THN is substrate of the hydroxynaphthalene reductase arp2 to yield scytalone (PubMed:10515939). The scytalone dehydratase arp1 then reduces scytalone to 1,3,8-THN (PubMed:10515939). 1,3,8-THN is also substrate of the hydroxynaphthalene reductase arp2 to yield vermelone (PubMed:10515939). Vermelone is further converted by the multicopper oxidase abr1 to 1,8-DHN (PubMed:10515939). Finally the laccase abr2 transforms 1,8-DHN to DHN-melanin (PubMed:10515939). DHN-melanin biosynthesis appears to be initiated in endosomes where early enzymes (abl1, ayg1, arp1 and arp2) localize, with exocytosis leading to melanin deposition on the cell surface where late enzymes (abr1 and abr2) localize (PubMed:26972005). DHN-melanin is an important structural component of the outer cell wall and is required for the presence of conidial surface hydrophobins (PubMed:19703288). DHN-melanin plays also a crucial role in fungal virulence, including a protective role against the host's immune defenses (PubMed:9620950, PubMed:9832321, PubMed:12464010,PubMed:16110796, PubMed:20145078, PubMed:21501368, PubMed:21747802, PubMed:21573171, PubMed:24818666, PubMed:24836942, PubMed:25810442, PubMed:26972005). DHN-melanin protects also conidia against amoeba predation (PubMed:25684622).
Mass
234.494 kDa
Sequence
MEDLHRLYLFGDQTISCDEGLRNLLQAKNHTIVASFIERCFHALRQEITRLPPSQRTLFPRFTSIADLLAQHRESGTNPALGSALTCIYQLGCFIDYHGDRGHPYPSSDDGLLGSCTGMLSCTAVSSCKNVGELLPLAVEIVRLTIHLGLCVMRVREMVDSTESSSGSWSILVSEINEADATSLIGNFVKKRGIPPSSQPYISAVGSKGLTISAPPEILDNFIEEGLPKEYKHFKAPGVSGPYHAPHLYNDREIRNILSFCSEDVILRHTPRVPLVSSNTGKLVQVKSMRDLLKVALEEILLRKICWDKVTESCLSIVQATNDKPWRILPIASNATQGLVTALQRMGNCQIEVDTGVGAPQMDPAAPNATGNASRSKIAIIGMSGRFPEADGIEAFWDLLYKGLDVHKKVPPERWDVDAHVDLTGTKRNTSKVPYGCWINEPGLFDARFFNMSPREALQADPAQRLALLSAYEALEMAGFVPNSSPSTQRDRVGIFMGMTSDDYREINSGQDIDTYFIPGGNRAFTPGRINYYFKFSGPSVSVDTACSSSLAAIHLACNAIWRNDCDTAISGGVNLLTNPDNHAGLDRGHFLSRTGNCNTFDDGADGYCRADGVGTIVLKRLEDAEADNDPILGVINAAYTNHSAEAVSITRPHVGAQAFIFNKLLNDTNTNPHEIGYVEMHGTGTQAGDAVEMQSVLDVFAPDYRRGPANSLYLGSAKSNIGHGESASGVTSLVKVLLMLKQNMIPPHCGIKTKINHNFPTDLAQRNVHIAFKPTPWNRPVSGKRKMFINNFSAAGGNTALLMEDAPLREITGQDPRNVHVVSVTARSQTALKRNINALIKYINTHAPSSPANERRFLASLAYTTTARRMHHPFRVTAVGSSVKDIREVLRQRADQDVTTPVPATAPKTGFVFTGQGAQYTGMGKQLYEDCATFRSTIHRLDCIAQSQGFPSILPLIDGSMPVEELSPVVTQLGTTCLQMALVDYWKGLGVTPAFVLGHSLGDYAALNSAGVLSTSDTIYLCGRRAQLLTQQCQMGTHAMLAVKAAVSEIQHLLDPDVHAVACINGPTETVISGLSGRIDELAQQCSSQNLKSTKLKVPFAFHSAQVDPILESFEESAQGVIFHEPAVPFVSALNGEVITESNYSVLGPTYMVKHCREAVNFLGALEATRHAKLMDDATLWVEVGSHPICSGMIKSTFGPQATTVPSLRRDDDPWKILSNSLSTLHLAGVELNWKEFHQDFSSAHEVLELPRYGWDLKNYWIPYTNNFCLTKGGPVTAEVSAPKSTFLTTAAQKIVECREDGNTATLVVENNIAEPELNRVIQGHKVNGVALTPSSLYADIAQTLVDHLITKYKPEYQGLGLDVCDMTVPKPLIAKSGDQFFRVSAVMSWAEQKASVQVWSVNGDGKKMAEHAHCTVKLFNCAERETEWKRNSYLIKRSVSLLQDKAQTGEAHRMQRGMVYKLFAALVDYDENFKAIQEVILDSNEHEATARVKFQAPPGNFHRNPFWIDSFGHLSGFIMNASDATDSKNQVFVNHGWDSMRCLKKFSGDATYQTYVKMQPWKDSIWAGDVYVFEGDDIIAVYGGVKFQALARKILDTVLPPIGGSKTVGAPAPAPARPIGEKKAPPPIKVTGPPKPNPSNARAASPVVARALEILAAEVGLSEAEMTDSLNFADYGVDSLLSLTVTGRYREELNLDLESSVFMDYPTIKDFKAYLAEKGFCDSSSPEPSSEPESKFSFNSDASSEASSGLTTPGITSPVKHEAPKGGQNKVWKSICSIIAEEIGVSVGDIDPSDNLPEMGMDSLLSLTVLGRIRETLGMDLPAEFFLENPTLDAVQAALDLKPKMVPAATPVSEPIRLLETIDNTKPKTSRHPPATSILLQGNPHTATKKLFMFPDGSGSASSYATIPALSPDVCVYGLNCPYMKTPQNLTCSLDELTEPYLAEIRRRQPKGPYSFGGWSAGGICAFDAARQLILEEGEEVERLLLLDSPFPIGLEKLPPRLYKFFNSIGLFGDGKRAPPDWLLPHFLAFIDSLDAYKAVPLPFNDSKWAKKMPKTYLIWAKDGVCGKPGDPRPEPAEDGSEDPREMQWLLNDRTDLGPNKWDTLVGPQNIGGIHVMEDANHFTMTTGQKAKELSQFMATAMSS

Gene
alb1
Protein
Serum albumin 1
Organism
Salmo salar
Length
608 amino acids
Function
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood.
Similarity
Belongs to the ALB/AFP/VDB family.
Mass
67.151 kDa
Sequence
MQWLSVCSLLVLLSVLSRSQAQNQICTIFTEAKEDGFKSLILVGLAQNLPDSTLGDLVPLIAEALAMGVKCCSDTPPEDCERDVADLFQSAVCSSETLVEKNDLKMCCEKTAAERTHCFVDHKAKIPRDLSLKAELPAADQCEDFKKDHKAFVGRFIFKFSKSNPMLPPHVVLAIAKGYGEVLTTCCGEAEAQTCFDTKKATFQHAVMKRVAELRSLCIVHKKYGDRVVKAKKLVQYSQKMPQASFQEMGGMVDKIVATVAPCCSGDMVTCMKERKTLVDEVCADESVLSRAAGLSACCKEDAVHRGSCVEAMKPDPKPDGLSEHYDIHADIAAVCQTFTKTPDVAMGKLVYEISVRHPESSQQVILRFAKEAEQALLQCCDMEDHAECVKTALAGSDIDKKITDETDYYKKMCAAEAAVSDDSFEKSMMVYYTRIMPQASFDQLHMVSETVHDVLHACCKDEQGHFVLPCAEEKLTDAIDATCDDYDPSSINPHIAHCCNQSYSMRRHCILAIQPDTEFTPPELDASSFHMGPELCTKDSKDLLLSGKKLLYGVVRHKTTITEDHLKTISTKYHTMKEKCCAAEDQAACFTEEAPKLVSESAELVKV

Gene
ALB1
Protein
Ribosome biogenesis protein ALB1
Organism
Saccharomyces cerevisiae (strain YJM789)
Length
175 amino acids
Function
Involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm (By similarity).
Similarity
Belongs to the ALB1 family.
Mass
19.287 kDa
Sequence
MPSKNSINRPKLTSNLHHKVHSLNKKRAQRERAGLLKPARSSVNSKSGEIKSVALDLYFQNKKNESQNSTAVTLQNASSSPASITTRTLSKKRAKKIERNLKYATQRKLLVDASAKLEDEMDIDLDGGKKVKENEKKSSLTLVKEALWSVIDDTASQGLIIENGQGTTLGGPFFP

Gene
ALB1
Protein
Ribosome biogenesis protein ALB1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
175 amino acids
Function
With ARX1, involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm.
Similarity
Belongs to the ALB1 family.
Mass
19.287 kDa
Sequence
MPSKNSINRPKLTSNLHHKVHSLNKKRAQRERAGLLKPARSSVNSKSGEIKSVALDLYFQNKKNESQNSTAVTLQNASSSPASITTRTLSKKRAKKIERNLKYATQRKLLVDASAKLEDEMDIDLDGGKKVKENEKKSSLTLVKEALWSVIDDTASQGLIIENGQGTTLGGPFFP

Gene
ALB1
Protein
Ribosome biogenesis protein ALB1
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
168 amino acids
Function
Involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm (By similarity).
Similarity
Belongs to the ALB1 family.
Mass
18.502 kDa
Sequence
MPSRNSINKPKDKLQRNSHASSIGKKRSARARNGIVTKSSTPRYETDSNAAPKATESKAIALYNGATTPTGVIINNTLSNKRSKKIARNKKYIAKRNEKLNIDLLADQEQMEVDEETEKEEQTKAKNQTKLDKIKEVLWAAVEDRVSEGLKVSSGTDGNGTTLGVQAF

Gene
ALB1
Protein
Ribosome biogenesis protein ALB1
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
162 amino acids
Function
Involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm (By similarity).
Similarity
Belongs to the ALB1 family.
Mass
18.035 kDa
Sequence
MPSRNSINRPKLTVNLNRKNSSISKKRDQRERAGLLQPARSSADSKSGKVKSVPLDLYFEGQKDDHASAKGITNKTLSKKRAKKIERNIKYAQQRRLLTDATAKLEADMEIDIDQKKTKDAKPKTALEQVKEALWNAVEDTSNSGLIIENGQGTVLGGPYFP

Gene
ALB1
Protein
Ribosome biogenesis protein ALB1
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
160 amino acids
Function
Involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm (By similarity).
Similarity
Belongs to the ALB1 family.
Mass
17.72 kDa
Sequence
MPSKNSINRPKQKLNLQHRVQKNAAKRSARERAGLLAPPRSSDQSQSGRAKSIPLDLFRGERVDQGPITTKTLSKKRAKKIERNLRYVEQRKLLVDVQAARESGMDIDVETAVSTKAKTQQTGPLQKVKESIWSALEDVAAQEMIVQTGAGTTLGGQFFP

Gene
ALB1
Protein
Ribosome biogenesis protein ALB1
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
160 amino acids
Function
Involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm (By similarity).
Similarity
Belongs to the ALB1 family.
Mass
17.706 kDa
Sequence
MPSKNSINRPKQKVNLNRKVHQRAAKRDAMEKKGLLAPARSSGTSKSGQLKSIPLDLYKGEHSTSGALTTKTLSKKRAKKIERNLKYVEQRKLLVDLQSQSEENGGMQIDAPVVKKEKETKKGQLEKMREAISTVLEDIQSQGLSLQTGSGTTLGGQYFL

Gene
ALB1
Protein
Ribosome biogenesis protein ALB1
Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294)
Length
158 amino acids
Function
Involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm (By similarity).
Similarity
Belongs to the ALB1 family.
Mass
17.647 kDa
Sequence
MPSKNSINRPKLTVNLNKKSQRLGQKRADRERKGLLQPERSSEASKSGEIKSVPLDLYFNGKESNNNSSITTKTLSKKRAKKIERNLKYAQQRKLLVDVQAKEDIDMNVESNKTKGNGKEKTPLTKMKDALWNVIEDTSSQGLTLKTGQGTTLGGPTF

Gene
ALB1
Protein
Ribosome biogenesis protein ALB1
Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)
Length
157 amino acids
Function
Involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm (By similarity).
Similarity
Belongs to the ALB1 family.
Mass
17.267 kDa
Sequence
MASKNSINKPKIKINAHSHAKTLGRKRAARARKNPSTKSSTSRYAEVSGTATKPSDSTAIALYTGEAPKPTGVVTNTTLSNKRAKKLARNQKYIDQRKNEGLGKEHEMDVEVETEEQRQSRLEQIKKALWSVVQNQSEGLYKVAVDAEGTTLGVQAF

Gene
ALB1
Protein
Ribosome biogenesis protein ALB1
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
153 amino acids
Function
Involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm (By similarity).
Similarity
Belongs to the ALB1 family.
Mass
16.842 kDa
Sequence
MAGRNAINKPKIKLHAQSHAKSLGRKRAARRTTATRSSTSRYAAKGTTAPRPTDSKAVALYTGNAPQPTSTMTTQTLSNKRAKKIARNQRYLAANKLKENETAMEVDNTSEQEKQTKLDQIKKALWSVIENHQKNGYSVVSDPEGTTLGIQSF

Gene
ALB1
Protein
Ribosome biogenesis protein ALB1
Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)
Length
149 amino acids
Function
Involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm (By similarity).
Similarity
Belongs to the ALB1 family.
Mass
16.693 kDa
Sequence
MAGRNAINKPKIKMLAQSHARSLSRKRAARSSVQTRSSTSRYASKSLTAPRPTDSKSLALYTGETPLSQSVMTTNTLSKKRAKKIARNQKYLSQKQEDELMMDMDKQMKEKSRLDKVKKALWDLIENFEKNGPTVLPTGEGTTLGVQSF