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akirin

Gene
akirin
Protein
Akirin
Organism
Drosophila melanogaster
Length
201 amino acids
Function
Required for embryonic development and for normal innate immune response. Effector of immune deficiency pathway (Imd) acting either downstream of, or at the level of, the NF-kappa-B factor Relish (Rel). Not part of the Toll pathway (PubMed:18066067). NF-kappa-B factor Relish (Rel) cofactor that orchestrates NF-kappa-B factor Relish (Rel) transcriptional selectivity by recruiting the Osa-containing-SWI/SNF-like Brahma complex (BAP) through bap60 interaction, leading to activation a subset of NF-kappa-B factor Relish (Rel) effector genes (PubMed:25180232).
Similarity
Belongs to the akirin family.
Mass
22.705 kDa
Sequence
MACATLKRALDWESMNQRPPKRRRCNPFGQAGSNAGPASPSRDGPSTSAGLPHTPSNRFAKDSTEPSPFSESSLAKMSPDKMAESLCNEIKRLHKRKQLPITSSALERMQDSESSGSEMGPESPRRPDSPQNLMRHGEKALFTFKQVQLICESMIKERENQLRERYESVLTTKLAEQYDAFVKFTYDQIQRRYEAAPSYLS