Protein
Axin interactor, dorsalization-associated protein A
Function
Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by axin/JNK-signaling (By similarity).
Similarity
Belongs to the AIDA family.
Sequence
MSDMNKILHKWSASLKKGTDFDSWGQLVEAIDEYQILARQLQKEAQSPANSSDFTEDQKKTIGKIATCLGLRSAALQYTQSQEGFTLEDVKKLEPILSSIVTFNKEFPFDVQPVPLRRILAPGEEENLEVDEEEEDGGAGIGSPDLFPARVPGTLLPRLPSEPGMTLLTIKIEKIGLKDAGQCIDPYITVSVKDLNGIDLTPVQDTPMATRKEDTYVHFNVEIEIQKHVEKLTKGAAIFFEFKHYKPKKRFTSTKCFAFMEMDEIKPGQTVIELYKKPTDFKRKKLQLLTKKPLYLHLLQTLLKD