AI4

Intron-encoded DNA endonuclease aI4

556 amino acids

Mitochondrial DNA endonuclease involved in intron homing. It introduces a specific double-strand break at the junction of the two exons a4-a5 of the COX1 gene and thus mediates the insertion of an intron, containing its own coding sequence (group I intron), into an intronless gene. Recognizes with limited specificity and cleaves the sequence 5'-TTTGGTCACCCTGAAGTA-3'. The protein may acquire mRNA maturase activity, like the closely related bI4, through a single amino acid substitution Glu-362 to Lys or when present together with a mutant form of the imported mitochondrial leucyl-tRNA synthetase NAM2.

In the N-terminal section; belongs to the heme-copper respiratory oxidase family.

63.311 kDa

MVQRWLYSTNAKDIAVLYFMLAIFSGMAGTAMSLIIRLELAAPGSQYLHGNSQLFNVLVVGHAVLMIFFLVMPALIGGFGNYLLPLMIGATDTAFPRINNIAFWVLPMGLVCLVTSTLVESGAGTGWTVYPPLSSIQAHSGPSVDLAIFALHLTSISSLLGAINFIVTTLNMRTNGMTMHKLPLFVWSIFITAFLLLLSLPVLSAGITMLLLDRNFNTSFFEVSGGGDPILYEHLFWFFGQTVATIIMLMMYNDMHFSKCWKLLKKWITNIMSTLFKALFVKMFMSYNNQQDKMMNNTMLKKDNIKRSSETTRKMLNNSMNKKFNQWLAGLIDGDGYFGIVSKKYVSLEITVALEDEMALKEIQNKFGGSIKLRSGVKAIRYRLTNKTGMIKLINAVNGNIRNTKRLVQFNKVCILLGIDFIYPIKLTKDNSWFVGFFDADGTINYSFKNNHPQLTISVTNKYLQDVQEYKNILGGNIYFDKSQNGYYKWSIQSKDMVLNFINDYIKMNPSRTTKMNKLYLSKEFYNLKELKAYNKSSDSMQYKAWLNFENKWKNK

aI4

Probable intron-encoded endonuclease aI4

530 amino acids

Mitochondrial DNA endonuclease involved in intron homing.

In the N-terminal section; belongs to the heme-copper respiratory oxidase family.

59.676 kDa

MVRWLYSTNAKDIGTLYLIFAVFAAMIGTAFSVLIRMELAAPGVQYLNGDHQLYNVIITAHAFVMIFFMVMPAMVGGFGNYLVPVMIGAPDMAFPRLNNISFWLLPPSLILLLASAFVEQGAGTGWTVYPPLSGLQSHSGGSVDLAIFSLHLSGISSMLGAMNFITTVLNMRNPGMTLHKLPLFVWAIFVTAILLLLSLPVLAGKFVPALNLAVCWELFSSVFSKIIDVKDDQQVTYESYNFIWNLNDCAPELSISHMSSLLFFGSYLAGLIEGDGTIVVPKQERSAKGKRNYPSVQIVFQLKDFPLCQIVQKLIGHGTISKKKQAAAYILTINNIQGLIELSNLINGKIRGPKYYQFVLLVEYLNKKCPNLNLKPAGFNKTPLGFDSWLSGFIEADGSFQVRTSLSSKYPRLSLSFELVQSRITHYGFTMFTIMQEIAIFLETNVNEIRSERKNPQYRLRTSSLKTNKNIRDYLVKYPLKGTKYLDFKDWCKVLSYFEQGTHMDNTARIVEIKSQMNQRRTVYNWDHLQ

ai4

Intron-encoded endonuclease ai4

159 amino acids

Mitochondrial DNA endonuclease involved in intron homing.

Belongs to the LAGLIDADG endonuclease family.

19.358 kDa

MIYEFFNKNGYCTNNIPRKYIVKLKHNDDVKDFERYEFVTYTFRSFKYIYEMFYKKQKKVLHLEKIKEYLDERALAHWIMDDGGYTGAGIRIATNAFTLKEVMFLKELLEDKFKLKCTIQEIYIKDKWSIYITKDSMTHLISIIKPYMHPSMYYKLGIK