Protein
S-inosyl-L-homocysteine hydrolase
Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Function
Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.
Similarity
Belongs to the adenosylhomocysteinase family.
Sequence
MTEQELVESGNMKMEWARNHMPVIAIIREKFEKEKPLKGLKVGMALHVEAKTAVLVETLAAGGAQVAISGCNPLSTQDDVARALDTRKNISCFARYGCCTSEYYEAIDKVLDIEPDITIDDGADLIFKLHKERTDLLPKILGGCEETTTGVHRLHAMEKEGALKMPVIAVNDAMTKYLFDNRYGTGQSAWDGINRTTNLLVAGKNVVVGGYGWCGRGVAMRAAGLGANVIVTEVDPIRALEARMDGYRVMRMADAARLGEIFVTTTGNRDILTAEHFKVMPDGAVLANSGHFNVEIDMEALTSLAKSVKTVRHNIKEYDIGDRRINVIAEGRLVNLAAGDGHPAEVMDMSFANQALCVRYIAENTLLNGVHGVPRGIDTYVAKLKLESMGISIDELTSKQECYMTGWECGT