age-1

Phosphatidylinositol 3-kinase age-1

1182 amino acids

Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause (PubMed:8700226). Promotes cell survival during embryonic development by recruiting akt-1/2 to the plasma membrane through the production of PtdIns(3,4,5)P3 (PubMed:25383666). Could function in the development or neuroendocrine signaling of the dauer pathway (PubMed:8700226). Mediates susceptibility to enteropathogenic E.coli infection (PubMed:16091039). May negatively regulate AYI interneuron neurite outgrowth (PubMed:22069193). Plays a role in aversive olfactory learning when an odor is associated with food deprivation (PubMed:27383131). Regulates this process by promoting the nuclear relocalization of egl-4 in AWC olfactory neurons after odor conditioning (PubMed:27383131).

Belongs to the PI3/PI4-kinase family.

136.873 kDa

MSMGRSPSTTFRSRTGSHGARDLIAGHGRNSRRISQMHVNILHPQLQTMVEQWQMRERPSLETENGKGSLLLENEGVADIITMCPFGEVISVVFPWFLANVRTSLEIKLSDFKHQLFELIAPMKWGTYSVKPQDYVFRQLNNFGEIEVIFNDDQPLSKLELHGTFPMLFLYQPDGINRDKELMSDISHCLGYSLDKLEESLDEELRQFRASLWARTKKTCLTRGLEGTSHYAFPEEQYLCVGESCPKDLESKVKAAKLSYQMFWRKRKAEINGVCEKMMKIQIEFNPNETPKSLLHTFLYEMRKLDVYDTDDPADEGWFLQLAGRTTFVTNPDVKLTSYDGVRSELESYRCPGFVVRRQSLVLKDYCRPKPLYEPHYVRAHERKLALDVLSVSIDSTPKQSKNSDMVMTDFRPTASLKQVSLWDLDANLMIRPVNISGFDFPADVDMYVRIEFSVYVGTLTLASKSTTKVNAQFAKWNKEMYTFDLYMKDMPPSAVLSIRVLYGKVKLKSEEFEVGWVNMSLTDWRDELRQGQFLFHLWAPEPTANRSRIGENGARIGTNAAVTIEISSYGGRVRMPSQGQYTYLVKHRSTWTETLNIMGDDYESCIRDPGYKKLQMLVKKHESGIVLEEDEQRHVWMWRRYIQKQEPDLLIVLSELAFVWTDRENFSELYVMLEKWKPPSVAAALTLLGKRCTDRVIRKFAVEKLNEQLSPVTFHLFILPLIQALKYEPRAQSEVGMMLLTRALCDYRIGHRLFWLLRAEIARLRDCDLKSEEYRRISLLMEAYLRGNEEHIKIITRQVDMVDELTRISTLVKGMPKDVATMKLRDELRSISHKMENMDSPLDPVYKLGEMIIDKAIVLGSAKRPLMLHWKNKNPKSDLHLPFCAMIFKNGDDLRQDMLVLQVLEVMDNIWKAANIDCCLNPYAVLPMGEMIGIIEVVPNCKTIFEIQVGTGFMNTAVRSIDPSFMNKWIRKQCGIEDEKKKSKKDSTKNPIEKKIDNTQAMKKYFESVDRFLYSCVGYSVATYIMGIKDRHSDNLMLTEDGKYFHIDFGHILGHGKTKLGIQRDRQPFILTEHFMTVIRSGKSVDGNSHELQKFKTLCVEAYEVMWNNRDLFVSLFTLMLGMELPELSTKADLDHLKKTLFCNGESKEEARKFFAGIYEEAFNGSWSTKTNWLFHAVKHY

age-1

Phosphatidylinositol 3-kinase age-1

1159 amino acids

Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause. Promotes cell survival during embryonic development by recruiting akt-1/2 to the plasma membrane through the production of PtdIns(3,4,5)P3. Could function in the development or neuroendocrine signaling of the dauer pathway. Mediates susceptibility to enteropathogenic E.coli infection. May negatively regulate AYI interneuron neurite outgrowth. Plays a role in aversive olfactory learning when an odor is associated with food deprivation. Regulates this process by promoting the nuclear relocalization of egl-4 in AWC olfactory neurons after odor conditioning.

Belongs to the PI3/PI4-kinase family.

133.936 kDa

MSMGRSSSTTFRNRTASHGSRSLGSAETARIPRKLSSQLSHTHANILHPQLQTMMEQWQMRERPSLETENGKGSLLLSSEGVADMIVLSSFGEVISVVFPWFLANVRTSFDIKLSEFKHQLFEQIGPMKWGKHSTQPQDYAFRQLNNFGEIEVIFNDDQQLSCLELHGTFPMLFLFEPDGFNRDKELMCDISHCLGYSLDKLEESIDEELRQFRASLWTQTKKTCFERGVDGVDHYAFPEEQYFCVGEKCPTDLESKVKAAKLDYQLFWTKRKSEANEVWEKMYKITIDFDPEFNPQSLMRMFVKELQCMNLFDPEDPPDEEWILQLAGRTSFVTRPEISLVSYDGIRSELESYRCPGFVVRRKSLVLKDYVRPKPLYEPHYVRVHERKMALDVLSVSIGTEVKHSGNSDKVWTDFRPTASLEQITLWDLDSNLMIRPVNVTGLPFTASHDIYLGMEFKVYVGTLTLATIKIPRVPTTKLVWKREFFTFDLYMKDMPPSAILSVRVYSMKTTKMKEEIELGWVNISLSDWRDELRQGQIKLNLWGPEPSANRSRIGHNGAKIGTSLSVTVEISSHGRRVKMPNEAQYKYLVDHRISWSDTVEIVGDDYEACIGDPGYKKLQDLVKKHESGVILDDSEQRHVWSWRNYIQKQEPDLLVVLSELRIVWTDRENFSELYVMLETWKAPSVAAALTLLGKRCTDRVIRKFAVNKLNDQLSQFNVHLFLLPLIQALKYEPRAYSEVGMMLLTRALSSYRIGHRLFWLLRSEICRLKDCATNNEEYRRISLLMEAYLRGNEEHIKGIIRQVDMVDELTRISSLVKGLSKEAAREKLRDQLRTISHKMESIDSPLDPVYKFGEMVIEKAIVLGSAKQPLRLVWKNKNPKSDLHLPFCEVIFKNGDDLRQDMLVLQVLEVMDTIWKAANIDCCLSPYGVLPMGEMIGIIEVVPNCKTIFEIQHKAGLVNTAARSVDSNFMNKWIRKQCGFVDEKKKYKKGGGPTVDSAQATKKYFESVDRFLYSCVGYSVATYIMGIKDRHSDNLMLTEDGKYFHIDFGHILGHGKTKLGIQRDRQPFILTEQFLTIIRSGKPVDGNSHEIQKFKTLCLEAYEVMWNNLKYKFQKTLCCKGETKEKARKFFAGVYEEAFNGSWSTKTNWLFHAMKHY