Protein
Serine/threonine-protein kinase AfsK
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Function
Involved in the regulation of secondary metabolism by phosphorylating, on both Ser and Thr, the AfsR global regulatory protein involved in the control of secondary metabolism.
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Sequence
MVDQLTQHDPRRIGPFEVLGRLGAGGMGLVYLARSASGRRVAIKTVRTELAEDQLFRVRFTREVEAARAVSGFYTAAVVDADPRAAVPWLATAYVPAPSLEEIVNECGPMPAQAVRWLAAGVAEALQSIHGAGLVHRDLKPSNVLVVEDGPRVIDFGIASGVSNTRLTMTNVAVGTPAYMSPEQAKDSRSVTGASDVFSLGSMLVFAATGHPPFHGANPVETVFMLLREGPDLEGLPDELRPLIESCMQMEATGRPNPADLQAQLAPHLFGSGSDDSGTASAWLPERAVGLIEGRRNGRPAVKPATTAGGRGHGHGPSGARAPVHAPPLPPPPAHDPVVPAPPAHVPAVPAPVGAPDGGPVRLPGAAVPIGPGPRVADMRAAAVAAPPPESALAASWSRPRPGVNGADPAVPAPAPAPPEASPAGWRPWRFRMSNDVWGTPRVAEDLVYVTSFEVHALDVATGRRRFKTRDVAWSMAVADGRIHASDGPTLFALDAREGADLWRVQTDAWVYSLQADRGTVLTATRGGGVQAWEASAGQKLWEVTGAQTDFESPEAGAALHDGTAYVWQDARLRALDARTGDERWSYPIGDAASCGGVPVRLTQAPDGYVYVAAGTRVLALEVASGHVRWHFEAPAVFLAPPTFVPGPAVTGGGVYLADYLGTVYALDATDGRDRWRIATEARSSTDPVLVAAGHVHVGSGKGLYTLDAVTGTPKWRFQAGGDIVGAPAVAEGRIHFGSSDHLLYTLKADDGRLRWKLATGGEITGSPVVRDGIVYACSKDRCVYALDAEKGTGTARTT