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aflS

Gene
aflS
Protein
Aflatoxin cluster transcriptional coactivator aflS
Organism
Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1)
Length
438 amino acids
Function
Transcription coactivator involved in regulation of the aflatoxin biosynthesis gene cluster with aflR (PubMed:15006741, PubMed:11913765, PubMed:12655397, PubMed:15054098, PubMed:23605486). The ratio of the expression data between aflS:aflR plays a crucial role in the regulation of aflatoxins production (PubMed:23605486). A high ratio, produced at a range between 17 and 30 degrees Celsius, corresponds with the production profile of aflatoxin G1 biosynthesis (PubMed:23605486). A low ratio, produced over 30 degrees Celsius, is related to aflatoxin B1 biosynthesis (PubMed:23605486). AflJ may act in aflR transport to or from the nucleus, thus controlling the availability of aflR for transcriptional activation of aflatoxin biosynthesis cluster genes (PubMed:23342682). AflJ may also assist in directing endosomes to the cytoplasmic membrane for aflatoxin export (PubMed:23342682).
Mass
47.229 kDa
Sequence
MTLTDLETCAEEIATAARTLARDGHSGGYSAGLPDHLRAVQRTLIANASQVLALASQPADLVRQLALYNQLLACLRWLGEFQVLACIPLDESVPFEDVADIAGVPECRLRRLVRPLFTIGFLCEPSPGHVAHSVLSKQFVTQPALLDAILFMSETLAPSASAMGTQTRRFGASEQAGDSAWNMAVGSDSPFAACLQQRPKVKRQLGAYLSYVSSAIDAGVEDTLTRMNWQNLGMATVVHVGAQSPSLVVALAPQFPSLRFLVQTEAKAESGGHQPCLDNHGIPALKLASIPLHLRARITWGTRLSTATQPVLDAAVYLISIPFPSPQSPAMEITMRVAQALKAHVEVLRNNSDARLILTLPMSSATRSMDAAARAAVSLSDLSLLQLTNGGSLNMGEIRDLLRSRSDGLVVMREVRSPTNAVIAFEIQYRVDNDDNRY