Function
Involved in retrograde signaling from post-synaptic cells to pre-synaptic neurons, probably by regulating vesicle exocytosis in post-synaptic cells (PubMed:11804572, PubMed:2323555, PubMed:19028454). Acts in muscles, to regulate the localization of synaptic vesicle fusion protein unc-13 likely during vesicle exocytosis and thus regulate retrograde signaling at the neuromuscular junction (NMJ) (PubMed:11804572). Regulates anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP) (PubMed:11804572, PubMed:2323555, PubMed:19028454). Probably by regulating DMP, plays a homeostatic role in the uptake of triglycerides (PubMed:25849533). Regulates locomotion (PubMed:11804572).
Sequence
MREEALESICAALSISFTEDPDHLESIIDRFSEIFKVKDHLNQLRKKCEKFQTFTLEIRPVGSSNCTENVYAYIIESETCRQLELKPTGTTKLEIGSDKNVSLKFGLSQKKDSTTSKKGLSRSASLLKKLKFSDKKNLDELKISIFPLDIAVRKNINLGSGKSTLLEMKLIRNDHRNMIQCLEFDDFLEMTRSFHEWQAQISESELYDGSLGDPTFSMFYSIAFFFEIPSFVLKLTEMTCFLVWDDEMKKLDERALADVSLKMTACESEVDLQHPLLSPALSYLNDCTCNTIRCILVPFSTEPFFPPVSPSRLKSINVALKLIADICVLDVWDEFENLANPSNFLSSELKKLLESSAERYGESLKKQEFNELCRTILNLWMSLSNESQPYYIFFHQFDINYIGAAMLKLDKYLAESIQISLKCQLDLLNLRIPTELENFTKTTMRLFVTLRNLLNMVEAFHLPECQLFHFEEWFTDISVFWTYSWREVTLQMVERTITLDEDGDSVKYGARRPLPAGLYSFLCIQKGISDDLARLEFTFPHHLVVCAASVVNIMCQNINAYARKLFSEAMRNHEEKASRLVRATNGIEQAMCFVEEGYRRFAQFQRLEEYVDVDDLSAVRSTSIRLLKSTRDTCEIQVSTLLSHFVNLKTDIVLKIAKNLCADGKESNSGLKSYMRELASSERIESILECCYGLVDDVRCLLLPNCFKLSTQHFATSLEQQIRKNIRQKQPAEYYSNIYVGFLNILIFKRLKQMYLKFQIALKYIYEFLEIEDRKDIELLSNLHLNSFSTKDLILSYYDSLCEKIDRTRFGNAPHVDVHISYVKMVDEDTISIQIKLIKMSPIEWIDVISDRVDYFVRLELFPKILFPSNKFESPTTNPMPQSTRPQWKQLFEIRVPLECFFLRGACLAISVFDHERFIDRLVGRGFISLHSVPQASEEKPTQRLQVPLLPNDFSDQNNVFYQLLKTRACRDSIAKEFIETRTRRHQRIRALQHYIRINRNRVGHMLLG