Function
Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:12426375). Acts primarily on non-coding regions of protein-coding genes including introns and untranslated regions (UTR) (PubMed:28925356, PubMed:25373143). Required for normal chemotaxis (PubMed:12426375, PubMed:14657490). Edits the 3' UTR of clec-41 which is required for normal clec-41 expression and for chemotaxis (PubMed:28925356). Plays a role in determining lifespan (PubMed:20011587, PubMed:25373143). Not required for RNA interference (PubMed:12419225). Likely to play a role in determining whether a dsRNA enters the RNAi pathway (PubMed:14657490).
Sequence
MSVEEGMEVELKSEKMDLDDNIPDFVKETVERSGKNPMSLFSELYVHMTGNTPVFDFYNRNQPNGSMKFICVVILNGERIEGNVKSKKKEAKVSCSLKGLEVVLKHVSEYVVPAVKFEEKTTFFEMLREHTYAKFYELCKNNALIYGFEKVIASVFLKINGNLQIIALSTGNKGLRGDKIVNDGTALIDCHAEILARRGLLRFLYSEVLKFSTEPPNSIFTKGKNALVLKPGISFHLFINTAPCGVARIDKKLKPGTSDDLQNSSRLRFKIDKGMGTVLGGASEFEAPQTFDGIMMGERMRTMSCSDKLLRANVLGVQGAILSHFIDPIYYSSIAVAELNNADRLRKAVYSRAATFKPPAPFHVQDVEIGECQVEDTEQSTSAAARSTISSMNWNLADGNTEVVRTSDGMVHDKDMSGADITTPSRLCKKNMAELMITICTLTKTSVDYPISYEELKAGSQEYAAAKKSFITWLRQKDLGIWQRKPREFQMFTIN