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adr-1

Gene
adr-1
Protein
A-to-I RNA editing regulator adr-1
Organism
Caenorhabditis elegans
Length
964 amino acids
Function
Required for the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:12426375). Does not have deaminase activity but binds to dsRNA and regulates A-to-I RNA editing, possibly by modulating the accessibility of the double-stranded RNA-specific adenosine deaminase adr-2 for target adenosines (PubMed:24508457, PubMed:25373143). Regulates editing efficiency of specific adenosines in 3' untranslated regions of target mRNAs (PubMed:24508457). Represses editing efficiency of the Y75B8A.8 3' UTR in neurons (PubMed:26917557). Required for correct expression and A-to-I editing of clec-41 (PubMed:28925356). Required for normal chemotaxis (PubMed:12426375, PubMed:14657490). Also required for normal vulva development (PubMed:12426375). Plays a role in determining lifespan (PubMed:20011587, PubMed:25373143). Not required for RNA interference (PubMed:12419225). Likely to play a role in determining whether a dsRNA enters the RNAi pathway (PubMed:14657490).
Mass
107.427 kDa
Sequence
MDQNPNYNFGYGQAYGSGTDHTSDSTNNYNWASQWSQPESAASLATHTFPQYVSQQQQQQQQQAQQQAQNTYAAMNPISTFMQQQQRAQTFPQKKYGQQGGAPKPSAIRNNNFGAFGGGHALSQEWVQPMSQNQMGGPQGNRFFNNQKGGPFNQNKPNWRQNKPKGPAAPKKFDSTGKSPAMLLHELFKDVSEEYTEVEGVPKKYCCTLKVNGRTFQMESVNKKAAKQKCSELVVRDLRPDVHVTPFEEGVAAKAAAPVKKEIDAASGNGQNNKRNLLQADAISNQPTPKKVSAVKKAKLQLTPVESALSLLDLMQKIIAESAEKYSPVFEASEVPKDPEIPEVEVKKEEVDTNGENVANEKKSGWRKNETMHNVTLKFVEQNKQYTKMGPSRGVLKDMVIREALRDLFNVSHADITTVARRHASNRLGHDTTILQCLNTICSILNCTLTIECEPAEDRPLGIGRAYFMAKCTIIDHNENDLKFEVKSSSLASKAMAKDWVAQETLKNYFAIDPSSCVKTDAVSSQGPCALLHAMLNKQTKQKCKIAYEFKDNVPPVAGQATTTFYCECVIDETDRYIGVGRSKKLAKSEAAMQALKKLFKIDYDPAGNYPLALTSRAMTESKVSPLCRHIAEFCKREYHQMTEYYQIPPSNLFAAFLLVNAQEEKRVLAMGSSIQYIVEPDTLSGANGTSLLHLDAIILARRAMLKAFIHELSTVDSECSIFEKKEEGKAALKPNLRLVLYSNYSPPCIHAVDDAATKKLSYVTPTNLTCVPDDVLTYEQIKETKSLRVHCTADKLFKWNTLGIQGALLSNVLHPIFIDNIFFGSEAPVSDESLSYALQGRLGPNENEREIIVESMPVQMRMHMGISHLWHRGVDSVETLDYNTGRTSKGSPSRVCKAEIFEAYRKLNGVDQAVVNYAKAKEMASEYQYEKKVFYEKLEAAGLGKWQTKPAELVDSFTLAAFD