Ada2a

Transcriptional adapter 2A

562 amino acids

GCN5-independent Rpb4 complexes are highly enriched in decondensed chromosome puffs so may play a role in RNA polymerase II-dependent transcription.

65.625 kDa

MSFMNPVDMVDEDAADLQFPKVALLHIFTTLNCLFAVEPLGPQVKRFIHAHQNEHTRNSMVLYNPHTLHRYLEEMEEKTRDQNSSVPSATKDANRCATCRCSLTEPYIKCSECLDTLLCLQCFSRGKEAFSHRNNHAYIIVRDNIQVFADEPHWTARDERILLKTLRTHGYGNWEAVSQALDQRHEPAEVRRHYHDCYFGGIFERLLNLKHARDSYVPERMPYVFKMRSLDPPRHDDIASMQFRLSAGYRCARGDFDTPYDTSAESLLSIMVDHRGRDDDNEASESEFEREVTEELQLGLVRAYNNRLRERQRRYKIMRQHGLIMPNRTVSWISKYVHAFGSDASCMRFLGFMQICPDPIKFDMLLESLRYYRELHSQLHKLYDLREHGVRTLSGAKLYARLSKERQQAQRDYSRLKQTDAFDWQQLVQHYESNRSGDPGPLAINSKLYVMNTRRKASPIEIGGGKHFTHCLTPTEYNFSLIPDLPGYSKLDDGERKLCSVARLVPQSYLDYKNQLVTEQAKLGYLRLADARRLIKIDVNKTRQIYDFLLEHGHISRPPSYG

ADA2A

Transcriptional adapter ADA2a

548 amino acids

Required for the function of some acidic activation domains, which activate transcription from a distant site. The exact mechanism of action is not yet known (By similarity). ADA2 stimulates the acetyltransferase activity of GCN5 on free histones or nucleosomes, probably by opening up the promoter region.

62.042 kDa

MGRSKLASRPAEEDLNPGKSKRKKISLGPENAAASISTGIEAGNERKPGLYCCNYCDKDLSGLVRFKCAVCMDFDLCVECFSVGVELNRHKNSHPYRVMDNLSFSLVTSDWNADEEILLLEAIATYGFGNWKEVADHVGSKTTTECIKHFNSAYMQSPCFPLPDLSHTIGKSKDELLAMSKDSAVKTEIPAFVRLSPKEELPVSAEIKHEASGKVNEIDPPLSALAGVKKKGNVPQAKDIIKLEAAKQQSDRSVGEKKLRLPGEKVPLVTELYGYNLKREEFEIEHDNDAEQLLADMEFKDSDTDAEREQKLQVLRIYSKRLDERKRRKEFVLERNLLYPDQYEMSLSAEERKIYKSCKVFARFQSKEEHKELIKKVIEEHQILRRIEDLQEARTAGCRTTSDANRFIEEKRKKEAEESMLLRLNHGAPGSIAGKTLKSPRGLPRNLHPFGSDSLPKVTPPRIYSGLDTWDVDGLLGADLLSETEKKMCNETRILPVHYLKMLDILTREIKKGQIKKKSDAYSFFKVEPSKVDRVYDMLVHKGIGDST

ada2a

Adenosine deaminase 2-A

503 amino acids

Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. May play a role in the regulation of cell proliferation (By similarity).

Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.

57.506 kDa

MHVLFLGDLMWIYLLLLCCASCNGRPDPRKRDALIGLEASRRTGGDITLNEREKLLDGKLQKLKQHDMEAGQFPPSMHFFKAKRLIDQSPVFNLIQKMPKGAALHVHDFAMVSVDWLVKNVTYRENCYVCFTDKQTVQFIFSSGPPASSSYCSSWTLLRSLREKIKNTTELDNSFIRNLTLFTEDPDRAYPNQDTVWERFEQVFLVAYGLVTYAPVFKDYLYEGLRQFYEDNIMYVEIRALLPQTYELDGRLNDKDWSMAACQEVVNQFKKHHPDFIGARVIFTVHRKINATEAVKTVEEAMILRRNFPDVMAGFDFVGQEDLGRPLWYFKDALSLPEDKGFNLPYFFHAGETDSQGTDVDQNLMDALLFNTTRIGHGFALARHPVVKEMARKMDVPIEVCPISNQVLKLVSDLRDHPAAVLMAEGHPLVISSDDPAVFGATALSHDFYEAFMGFGGMSFNLGTLKELALNSLRYSTLPSQRKEEAIDALLVKWDKFVWESLL