Protein
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Function
Each of the constituent amino acids of the tripeptide acv are activated as aminoacyl-adenylates with peptide bonds formed through the participation of amino acid thioester intermediates.
Similarity
Belongs to the ATP-dependent AMP-binding enzyme family.
Sequence
MSPPGLLSEDGPGYSGGYADPTVPKVNWKQSNGKSAGGNGDVDAGNGNIDPSKSGVGVQVCFAGGLEGWKAGISKITERCDLSSIATNSTKYQLAVTGFSDGPDDYNEYSVPFPSEVLVAMEEMCLARDISMRSVIQFAVHYVLKGFGGGSHTVAASIDVGDDPNNIATSYTITPSIVCHESRQGQTVMQEIQSMEKLNQLRKQEMHPGEAGLSLIRMGLFDILVIFADANKCEGLIAGLPLAVMVCEGGGRLQVRIHFSGSLFRQKTLVDIAEALNVLFAKAASGGATPVRDLELLSAEQKQQLEEWNKTDGEYPECKRLNHLIEEATQLHEDKVAIVYKRRQLTYGELNAQANCFAHYLRSIGILPEQLVALFLEKSENLIVTILGIWKSGAAYVPIDPTYPDERVRFVLEDTQAKVIIASNHLAERLQSEVISDRELSIIRLEHCLSAIDQQPSTFPRANLRDPSLTSKQLAYVTYTSGTTGFPKGILKQHTNVVNSITDLSARYGVTGDHHEAILLFSAYVFEPFVRQMLMALVNGHLLAMVDDAEKYDAEKLIPFIREHKITYLNGTASVLQEYDFSSCPSLKRLILVGENLTESRYLALRRHFKNCILNEYGFTESAFVTALNVFEPGSARNNTSLGRPVRNVKCYILNKSLKRVPIGATGELHIGGLGISKGYLNRPDLTPQRFIPNPFQTDHEKELGLNQLMYKTGDLARWLPNGEIEYLGRADFQIKLRGIRIEPGEIESTLAGYPGVRTSLVVSKRLRHGEKETTNEHLVGYYVGDNTSVSETALLQFLELKLPRYMIPTRLVRVSQIPVTVNGKADLRALPSVDLIQPKVSSCELTDEVEIALGKIWADVLGAHHLSISRKDNFFRLGGHSITCIQLIARIRQQLGVIISIEDVFSSRTLERMAELLRSKESNGTPDERARPQLKTVAGEVANANVYLANSLQQGFVYQFLKNMGRSEAYVMQSVLRYDVNINPDLFKKAWKQVQHMLPTLRLRFQWGQDVLQVIDEDQPLNWWFLHLADDSALPEEQKLLELQRRDLAEPYDLAAGSLFRIYLIEHSSTRFSCLFSCHHAILDGWSLPLLFRKTHGTYLHLLHGHSLRTLEDPYRQSQQYLQDHREDHLRYWAGIVNQIEERCDMNALLNERSRYKIQLADYDKVEDQQQLTLTVPDASWLSKLRQTCSAQGITLHSILQFVWHAVLHAYGGGTHTVTGTTISGRNLPVSGIERSVGLYINTLPLVINQLAYKNKTVLEAIRDVQAIVNGMNSRGNVELGRLQKNELKHGLFDSLFVLENYPILDKSEEMRQKSELKYTIEGNIEKLDYPLAVIAREVDLTGGFTFTICYARELFDEIVISELLQMVRDTLLQVAKHLDDPVRSLEYLSSAQMAQLDAWNATDAEFPDTTLHAMFEKEAAQKPDKVAVVYEQRSLTYRQLNERANRMAHQLKSDISPKPNSIIALVVDKSEHMIATILAVWKTGGAYVPIDPEYPDDRIRYILEDTSAIAVISDACYLSRIQELAGESVRLYRSDISTQTDGNWSVSNPAPSSTSTDLAYIIYTSGTTGKPKGVMVEHHGVVNLQISLSKTFGLRDTDDEVILSFSNYVFDHFVEQMTDAILNGQTLVMLNDAMRSDKERLYQYIETNRVTYLSGTPSVISMYEFSRFKDHLRRVDCVGEAFSQPVFDQIRDTFQGLIINGYGPTEISITTHKRLYPFPERRTDKSIGQQIGNSTSYVLNADMKRVPIGAVGELYLGGEGVARGYHNRPEVTAERFLRNPFQTDSERQNGRNSRLYRTGDLVRWIPGSNGEIEYLGRNDFQVKIRGLRIELGEIEAVMSSHPDIKQSVVIAKSGKEGDQKFLVGYFVASSPLSPGAIRRFMQSRLPGYMIPSSFIPISSLPVTPSGKLDTKALPTAEEKGAMNVLAPRNEIESILCGIWAGLLDISAQTIGSDSDFFTLGGDSLKSTKLSFKIHEVFGRTISVSALFRHRTIESLAHLIMNNVGDIQEITPVDYDNRRKIAVSPAQERLLFIHELEGGGNAYNIDAAFELPPYIDQSRVEEALYTILSRHEALRTFLLRDQATGTFYQKILTTDEAKCMLIIEKSAVSTIDQIDSIVGRLSQHIFRLDSELPWLAHIVTHKTGNLYLTLSFHHTCFDAWSLKIFERELRVFCASNEKGGNMPILPMPQVQYKEYAEHHRRRLGKNQIQKLSDFWLQRLDGLEPLQLLPDYPRPAQFNYDGGDLSVILDGVVLETLRGIAKDHGVTLYAVLLAVYCLMLSTYTHQVDIAVGVPISHRTHPLFQSIVGFFVNMVVVRVDVKDFAVHDLIRRVMKALVDAQLHQDMPFQDVTKLLRVDNDASRHPLVQTVFNFESDMDKEFETTPSIQDTATIAPYQSVQRIKSVAKFDLNATATESGSALKINFNYATSLFRKETIQGFLETYRHLLLQLSYLGSQGLKEDTKLLLVRPEEMSGPHLPLAGLSNGAETLEAISLSRAFEFEAFRVPDRAAVVQGDKSLSYTELNKRANQLARYIQSVAHLRPDDKVLLILDKSIDMIICILAIWKTGSAYVPLDPSYPKERVQCISEVVQAKILITESRYASAWGSQTSTILAIDSPKVSNMVNNQATHNLPNIAGIKNLAYIIFTSGTSGKPKGVLVEQGGVLHLRDALRKRYFGIECNEYHAVLFLSNYVFDFSIEQLVLSIMSGHKLIIPEGEFVADDEFYITANGQRLSYLSGTPSLLQQIDLARLNHLQVVTAAGEQLHAAQFNKLRSGFRGPIYNAYGITETTVYNIVSEFSAQSQFENALRELLPGTRAYLLNHATQPVPMNAVGELYLAGDCVARGYLNQPVLTGDRFIQNPFQTEQDIASGSYPRLYRTGDLFRCRLDRQHQPYLEYLGRADLQVKIRGYRIEPSEVQNVLASCPGVRECAVVAKYENTDAYSRIAKFLVGYYTPDTETVSDSSILAHMKSKLPAYMVPKYLCRLEGGLPVTINGKLDVRKLPDIGNPQHQISYNPPRDVLEADLCRLWASALGTERCGIDDDLFRLGGDSITALHLAAQIHHQIGRKVTVRDIFDHPTIRGIHDNVMVKLVPHNVPQFQAEQQTVLGDAPLLPIQTWFLSKSLQHPSHWNHTFYLRTPELDVTTLSTAVAELQLYHDAFRMRLRQIDGRTVQCFADDISPVQLRVLNVKDVDGSAAIDQQLQKYQSDFDLEKGPICAAAYLHGYEDRSARVWFSVHHIIIDIVSWQILARDLQILYEGGTLGRKSSSVRQWAEALQSYQGSASERAYWEGLLAQTAANISALPPVTGTRTRLARTWSDDRTVILLNEASNQNASIQDLLLAAVGLALQQVTPGSPSMITLEGHGREEIVDPTLDLSRTLGWFTSMYPFEIPPLNVETLSQGIASLRECLRQVPARGIGFGSLYGYCKHQMPQVTFNYLGQLTSKQSITDQWALAVGDGEMQYGLTTSPADRDQSSFAVDITASCVNGALSVEMNSAWSLEKSMRFISRIEEVLNMILSGTLAQQATPVLTPQVFNEEMYTPYFEFSKTPRRGPILFLLPPGEGGAESYFNNIVKHLPTTNMVVFNNYYLHSKSLNTFEKLAEMYLGHIRQIQPDGPYHFIGWSFGGTIAMEISRQLVGLGSTIGLLGIIDTYFNVPGATRAIGLGDTEVLDPIHHISQPEPADFQCLPASTDYIILFKATRVNDKFQSENQRRLYEYYDKTLLNDLDWLLPGASNIHLVRLEEDTHFSWATNPRQIAHVCSTIEKFLARY