Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Function
Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2-methylisocitrate.
Similarity
Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
Sequence
MSYIEEEDQRYWDEVAAVKNWWKDSRWRYTKRPFTAEQIVAKRGNLKIEYPSNVQAKKLWGILERNFKNKEASFTYGCLDPTMVTQMAKYLDTVYVSGWQSSSTASSTDEPSPDLADYPMNTVPNKVNHLWMAQLFHDRKQREERMTTPKDQRHKVANVDYLRPIIADADTGHGGLTAVMKLTKLFVERGAAGIHIEDQAPGTKKCGHMAGKVLVPISEHINRLVAIRAQADIMGTDLLAIARTDSEAATLITSTIDHRDHPFIIGSTNPDIQPLNDLMVMAEQAGKNGAELQAIEDEWLAKAGLKLFNDAVVDAINNSPLPNKKAAIEKYLTQSKGKSNLEARAIAKEIAGTDIYFDWEAPRTREGYYRYQGGTQCAINRAVAYAPFADLIWMESKLPDYKQAKEFADGVHAVWPEQKLAYNLSPSFNWKKAMPRDEQETYIKRLGALGYAWQFITLAGLHTTALISDTFAKAYAKQGMRAYGELVQEPEMANGVDVVTHQKWSGANYVDNMLKMITGGVSSTAAMGKGVTEDQFKS