acrA

Adenylate cyclase, terminal-differentiation specific

2123 amino acids

Through the production of cAMP, activates cAMP-dependent protein kinases (PKAs), triggering terminal differential and the production of spores.

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

243.012 kDa

MTNNRLKNRKKPNQIHTISEEEEEEEPLFNNEDLQTQHLNSPSSDSISTSSSSSLSSVGGSVVGNNNSNSNGIDNNNSNNNNNNNNNNNNNNNNNNSNNNNNYTGNSIGGNDFKNKASSSSSTPTTSTGIGSSKFPNIKRKNSFSNRYDSGGGGSGSSRSNSFGGSNSSGGASKEFFYFDNDDMIQDDDLIPMLMQDQEHQLQTQYQNQQQVQQQQNIINSFINHENLKFPFSIIYTNKLHIWLSYFLFTFVLIFCCLAVGPLLWIELPPNSGCMWCRIFKLEWVISFMSLISAMFHYTIRRDMFPLYLSIIGFYHVLTYSEPFLEPFRVNNFFSLILTVICIFIAFYPKNKLRRQQASNHHQQQQQQQQQQRQRQQNNNRQPEKSIIKRIIQNEWFHSLIQILIVLGIVVLLFFSIFILALFMKDDKTFSGDVIDGNINSNNNNNNNNNNNINNNNIDNNNNNIKNNNKGFIEEIEQGEEQLELYLENAYHIFKELVFKKFISSSVVYLILITLLFCISLVYHWEVRKPYTLMALASMIPQLTQALYKVELTLTGVMDKGTMSHNVTPLGGGIFYILNVISYTSFYCGLAIDVVVASGEKYKRLKKRGEKYHRRLSTQINEQNAFVNKIYASGTAQLLQKVEFMQKFVDKILFSTLEISNRLQRLESSDQDIPSSLVDQLNDIQYQTNRSLLLLNDTKLILAIESGVISREDVSVNLFDFLEDVLERTSKDIKFNNIELVYKIDKDVPLNIILDPTALTQICFQLLSNAIKYTEEGEIGILIKRILRNDYEYQQEQQQPQQDNELPPFGTISEEDEEYNSNNPPPPLNQQQQQRQQQQQQEPKQIYLEISIFDSGPGMDDDELDICNQFQPFPDIGDEDDIEIKKKGSGLGLLICNKVLKSIGGDLIVERYLETGGCIFKCCIPVLVDPQPKENFTFQIPLSQETNELLSDLSVLVIDDNPYARDSVGFIFSSVFNSAIVKSANSSVEGVRDLKYAIATDSNFKLLLVDYHMPGCDGIEAIQMIVDNPAFSDIKIILMILPSDSFAHMNEKTKNITTLIKPVTPTNLFNAISKTFKLKEFSSVVDLVDLNAPDTSTQIPLKRNRLKFKIDFPFRLPETGKPIMRVLIGESDKSTQSKIQKVIESFGYFSTFVTDGTALISLSKKNYYDLVIVDLELQSTDGFECAQIIRDTHGEIFSNTIFVPKPISTNSNDDNNNNNNNNNNNNNNDNNNNNNNNNNNNNNNNNNNNNNNNNNNNSILTSSVDTDGNHIVSSSTSTSSSFPTRRSSIGSFQTASPSMTEISHRRRVKLPIIGIWHHSDIIPDDIIKKIKRVGFDGYCSFDNLEFYLQEFLLEFDRKRKSNILSPIRLFPNGSPSTNIYDYSSIISNLNQASGNNNNSSPISGILNENVISSPISLDLDLNSVSSIQSQSSSSSSSFQHNNQQQQQQQHQHQLTPTQQSIGGGNNGINQLSFSSQQSTPIFNQSQIQHQIISNRSKHSSLSSSTSSNGSGGSGGKSRFSIPMLPSSTNRDSSPHSSSKMALKRVQDLESVISKFVPIEFQQLIAPSGMENVYLGDAICKSITIFFSDIRDFTSTTEKMLVDDVIDFLNTYLAFALPSITDSGGFIDKFIGDAIMAIFPNSDMKLQAINAVKAAIRMMRSLDFMSISGFRFSSVETGVGINTGKTIIGIVGTENRMEPTALGDAVNLASRTEQLCKEYQSRILITQFTMEAIGTSIDEFVIRLVDSVTVKGKSEAVNIYEVIDGEREDKRVLKMKILPWYQNGMDLYKRHCYEEALSYFQLCTEIMPNDKPTLIYIQRCIQNIKTLELQQIQLQQLQRQQLLQQQQQQLLLQQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSQNIQQPQSQQSQYVQQPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPQQQQQLQQQQQHQQQKQPSPQQQQQPQQPQQQQQQQIQNQYQHQLQYQRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHHQQQQFQQQSQQSQQQSQQQQQQQQQQSQQQSQQQSQQIQKKSQHPHSQQIQSQRHQSQPQNVDTNVKTKPQQ

acrA

Multidrug efflux pump subunit AcrA

397 amino acids

AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together (By similarity).

Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

42.197 kDa

MNKNRGFTPLAVVLMLSGSLALTGCDDKQAQQGGQQMPAVGVVTVKTEPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFKEGSDIEAGVSLYQIDPATYQATYDSAKGDLAKAQAAANIAQLTVNRYQKLLGTQYISKQEYDQALADAQQANAAVTAAKAAVETARINLAYTKVTSPISGRIGKSNVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLKQENGKAKVSLITSDGIKFPQDGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGLNPNAILVPQQGVTRTPRGDATVLVVGADDKVETRPIVASQAIGDKWLVTEGLKAGDRVVISGLQKVRPGVQVKAQEVTADNNQQAASGAQPEQSKS

acrA

Multidrug efflux pump subunit AcrA

397 amino acids

AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm.

Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

42.197 kDa

MNKNRGFTPLAVVLMLSGSLALTGCDDKQAQQGGQQMPAVGVVTVKTEPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFKEGSDIEAGVSLYQIDPATYQATYDSAKGDLAKAQAAANIAQLTVNRYQKLLGTQYISKQEYDQALADAQQANAAVTAAKAAVETARINLAYTKVTSPISGRIGKSNVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLKQENGKAKVSLITSDGIKFPQDGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGLNPNAILVPQQGVTRTPRGDATVLVVGADDKVETRPIVASQAIGDKWLVTEGLKAGDRVVISGLQKVRPGVQVKAQEVTADNNQQAASGAQPEQSKS