Protein
Inactive angiotensin-converting enzyme-related protein
Organism
Caenorhabditis elegans
Function
Inactive as a metallopeptidase, due to a lack of active site residues (PubMed:14559923). Required for larval molting, male tail development, and formation of adult alae (PubMed:14559923). Acts in the heterochronic pathway and plays a role in the developmental timing of postembryonic hypodermal seam cell division and adult alae production (PubMed:28933985). Acts synergistically with apl-1 in let-7 regulated postembryonic cell division events (PubMed:28933985). Might act downstream of the heterochronic protein lin-41 (PubMed:28933985). Negative regulator of lifespan, heat and oxidative stress response and age-related degenerative changes like reduced pharyngeal pumping and decreased body movements (PubMed:26918946). Lifespan restriction is dependent on the forkhead-type transcription factor daf-16 (PubMed:26918946).
Similarity
Belongs to the peptidase M2 family.
Sequence
MKFHILLLLLVGACLPVFTQEIKPKPELLPADEAPKDPEAVFSEGEPFELTDALDTPKNGSVPVPEPEPKPEPEPEPEPKPEPEPSPTPEPEPAIKFDNIESEDYGDVAETAASTQPDELNTEVIEQLVDTFLNTGSIASNKTNKGPVFANPVAQALVNSSNYWKTDNLQAPGSIKDEEKLRSWLAGYEAEAIKVLREVALSGWRYFNDASPSLKLALDEAENVLTMFVRSTSMQAKQFDMASVTDEKVMRQLGYVSFEGMSALAPSRFADYSQAQAALNRDSKDSTICDKDVPPPCALQKIDMDSIFRNEKDASRLQHLWVSYVTAIAKSKPSYNNIITISNEGAKLNGFANGGAMWRSAFDMSSKVHKAEFDLNKQIDKIYSTIQPFYQLLHAYMRRQLAGIYSNPVGLSKDGPIPAHLFGSLDGGDWSAHYEQTKPFEEESETPEAMLSAFNTQNYTTKKMFVTAYRYFKSAGFPHLPKSYWTSSIFARVWSKDMICHPAAALDMRAPNDFRVKACAQLGEPDFEQAHSLLVQTYYQYLYKDQSLLFREQASPVITDAIANAFAHLSTNPHYLYSQKLVPSEHLDIKDSVIINKLYKESLESFTKLPFTIAADNWRYELFDGTVPKNKLNDRWWEIRNKYEGVRSPQPYNTSNLDALIHNSVSQVHSPATRTLISYVLKFQILKALCPEGTILSEGCILSEDTTEKLRETMKLGSSITWLKALEMISGKGELDAQPLLEYYEPLINWLRNTNEIDQVVVGWDGEGTPFTVEEIPKTRQPGDGGNGLPSEDRVAFPGGECVNGQECLLDSHCNGTICVCNDGLYTLEIGNTFNCVPGNPADSGFGDGKGGLVIGLFNNEVTTPEPSAEPEPTAKTTTKMPPRVRAATSPFSLYLTVLLIIYFAL