aceE

Gene

aceE

Protein

Pyruvate dehydrogenase E1 component

Organism

Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

Length

930 amino acids

Function

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

Mass

103.44 kDa

Sequence

MTTDFARHDLAQNSNSASEPDRVRVIREGVASYLPDIDPEETSEWLESFDTLLQRCGPSRARYLMLRLLERAGEQRVAIPALTSTDYVNTIPTELEPWFPGDEDVERRYRAWIRWNAAIMVHRAQRPGVGVGGHISTYASSAALYEVGFNHFFRGKSHPGGGDQVFIQGHASPGIYARAFLEGRLTAEQLDGFRQEHSHVGGGLPSYPHPRLMPDFWEFPTVSMGLGPLNAIYQARFNHYLHDRGIKDTSDQHVWCFLGDGEMDEPESRGLAHVGALEGLDNLTFVINCNLQRLDGPVRGNGKIIQELESFFRGAGWNVIKVVWGREWDALLHADRDGALVNLMNTTPDGDYQTYKANDGGYVRDHFFGRDPRTKALVENMSDQDIWNLKRGGHDYRKVYAAYRAAVDHKGQPTVILAKTIKGYALGKHFEGRNATHQMKKLTLEDLKEFRDTQRIPVSDAQLEENPYLPPYYHPGLNAPEIRYMLDRRRALGGFVPERRTKSKALTLPGRDIYAPLKKGSGHQEVATTMATVRTFKEVLRDKQIGPRIVPIIPDEARTFGMDSWFPSLKIYNRNGQLYTAVDADLMLAYKESEVGQILHEGINEAGSVGSFIAAGTSYATHNEPMIPIYIFYSMFGFQRTGDSFWAAADQMARGFVLGATAGRTTLTGEGLQHADGHSLLLAATNPAVVAYDPAFAYEIAYIVESGLARMCGENPENIFFYITVYNEPYVQPPEPENFDPEGVLRGIYRYHAATEQRTNKAQILASGVAMPAALRAAQMLAAEWDVAADVWSVTSWGELNRDGVAIETEKLRHPDRPAGVPYVTRALENARGPVIAVSDWMRAVPEQIRPWVPGTYLTLGTDGFGFSDTRPAARRYFNTDAESQVVAVLEALAGDGEIDPSVPVAAARQYRIDDVAAAPEQTTDPGPGA

Protein

Pyruvate dehydrogenase E1 component: aceE

Gene

aceE

Protein

Pyruvate dehydrogenase E1 component

Organism

Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Length

930 amino acids

Function

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). AceE has reductase activity with pyruvate but does not react with 2-oxoglutarate.

Mass

103.44 kDa

Sequence

Protein

Pyruvate dehydrogenase E1 component: aceE

Gene

aceE

Protein

Pyruvate dehydrogenase E1 component

Organism

Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

Length

929 amino acids

Function

Mass

103.077 kDa

Sequence

MTTEFVRQDLAQNSSTAAEPDRVRVIREGVASYLPDIDTEETAEWLESFDELLERSGPARARYLMLRLLERAGEQRVAIPALTSTDYVNTIPTELEPWFPGDEDVERRYRAWIRWNAAIMVHRAQRPGVGVGGHISTYASSATLYEVGFNHFFRGKSHPGGGDHVFIQGHASPGIYARAFLEGRLTTDQLDGFRQEHSHSGGGLPSYPHPRLMPDFWEFPTVSMGLGPMNAIYQARFNHYLHDRGIKDTSDQHVWAFLGDGEMDEPESRGLIQVAANEALDNLTFVINCNLQRLDGPVRGNGKIIQELESFFRGAGWNVIKVVWGREWDVLLHADRDGALVNLMNSTPDGDYQTYKANDGAYVRDHFFGRDPRTKALVADMSDQEIWNLKRGGHDYRKVYAAYRAAMEHKGQPTVILAKTIKGYTLGQHFEGRNATHQMKKLALEDLKNFRDVTRVPVSDAQLEEDPYLPPYYHPGPEAPEIRYLLERRRALGGFVPSRRTKSKPLALPGSDTYKALKKGSGSQAVATTMATVRTFKELLRDKNIGPRIVPIIPDEARTFGMDSWFPSLKIYNRNGQLYTSVDSELMLAYKESEVGQILHEGINEAGSTSSFTAVGTSYSTHDEPMIPIYIFYSMFGFQRTGDGLWAAADQMARGFVLGATAGRTTLTGEGLQHADGHSLLLASTNPAAVTYDPAFAYEIAHIIESGLQRMYGEDPENVFFYLTIYNEPYQQPAEPENLDVEALLKGLYLYRPAPEKRAKSAQILASGVAMPEALRAADLLASDWDVAADVWSVTSWGELNREGVAIEKHRLRHPDEPAGTPHVTSALADAAGPVIAVSDWMRAVPEQIRPWVPGTYVTLGTDGFGFSDTRPAARRYFNTDAESVVVAVLQGLARDGEIDASVAAQAAEQYRIDDVSAAGVSYADTGSA

Protein

Pyruvate dehydrogenase E1 component: aceE

Gene

aceE

Protein

Pyruvate dehydrogenase E1 component

Organism

Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)

Length

922 amino acids

Function

Is a specific component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). AceE has reductase activity with pyruvate but does not react with 2-oxoglutarate.

Mass

102.826 kDa

Sequence

MADQAKLGGKPSDDSNFAMIRDGVASYLNDSDPEETNEWMDSLDGLLQESSPERARYLMLRLLERASAKRVSLPPMTSTDYVNTIPTSMEPEFPGDEEMEKRYRRWIRWNAAIMVHRAQRPGIGVGGHISTYAGAAPLYEVGFNHFFRGKDHPGGGDQIFFQGHASPGMYARAFMEGRLSEDDLDGFRQEVSREQGGIPSYPHPHGMKDFWEFPTVSMGLGPMDAIYQARFNRYLENRGIKDTSDQHVWAFLGDGEMDEPESRGLIQQAALNNLDNLTFVVNCNLQRLDGPVRGNTKIIQELESFFRGAGWSVIKVVWGREWDELLEKDQDGALVEIMNNTSDGDYQTFKANDGAYVREHFFGRDPRTAKLVENMTDEEIWKLPRGGHDYRKVYAAYKRALETKDRPTVILAHTIKGYGLGHNFEGRNATHQMKKLTLDDLKLFRDKQGIPITDEQLEKDPYLPPYYHPGEDAPEIKYMKERRAALGGYLPERRENYDPIQVPPLDKLRSVRKGSGKQQIATTMATVRTFKELMRDKGLADRLVPIIPDEARTFGLDSWFPTLKIYNPHGQNYVPVDHDLMLSYREAPEGQILHEGINEAGSVASFIAAGTSYATHGKAMIPLYIFYSMFGFQRTGDSIWAAADQMARGFLLGATAGRTTLTGEGLQHMDGHSPVLASTNEGVETYDPSFAYEIAHLVHRGIDRMYGPGKGEDVIYYITIYNEPTPQPAEPEGLDVEGLHKGIYLYSRGEGTGHEANILASGVGMQWALKAASILEADYGVRANIYSATSWVNLARDGAARNKAQLRNPGADAGEAFVTTQLKQTSGPYVAVSDFSTDLPNQIREWVPGDYTVLGADGFGFSDTRPAARRFFNIDAESIVVAVLNSLAREGKIDVSVAAQAAEKFKLDDPTSVSVDPNAPEE

Protein

Pyruvate dehydrogenase E1 component: aceE

Gene

aceE

Protein

Pyruvate dehydrogenase E1 component

Organism

Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)

Length

888 amino acids

Function

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

Mass

101.458 kDa

Sequence

MSEKLYNYDVDPVETNDWVQSIESVIREEGLERAKFLIEKILKKSKITRANFFKCFFTSDYINTISSEEEVEYPGDLILEKRIRSAIRWNAIMMVLRASKKDLELGGHLSSFQSSATIYEVCFNHFFRSKNDEDGGDLVYFQGHIAPGIYARSFLEGRLSKKQIDNFRQEVDGKGLSSYPHPKLMPNFWQFPTVSMGLGPLCAIYQAKFLKYLQNRELKNTSKQTVYAFLGDGEMDEPESKGAISIAVREKLDNLIFVINCNLQRLDGPVVGNGKIVNELESFFYGAGWKVIKVIWGGKWDSLLKKDKTGKLIQLMNETIDGEYQTLKSKDGAYVRKYFFGKYQETLELVKNMTDEEIWNLNRGGHDPKKMFNALKKAKEIKDKPTVILAHTVKGYGMGVIAEGKNIAHQIKKININGIIYIRDRFNIPISNEDIKELPYVVFEKNSKEYCYMHQQRKKLGGYIPFRLSKFTNALNIPDLIDFKSLLKEQNKKMSTTIAFVRVLNLILKNHSIKNLIVPIIADEARTFGMEGLFRMIGIYSSIGQKYVPQDREQLAYYKEEKKGQILQEGINELGAASSWLAAATSYSTNDFPMIPFYIYYSIFGFQRIGDLFWAAGDQQARGFLIGGTSGRTTLNGEGLQHEDGHSHIQSLTIPNCVSYDPAFAYEVAVIIQDGLRRMYGPLQENIYYYITTINENYYMPAMPQGVEKGICKGIYKLKTFYATELKVQLMGSGAILRCICKAGEILSNDYCITTDIYSVTSFTELARNGEDCERWNMLHPYEKKRIAYIKTVMNSSPAVAATDYMKLFAEQIRHYIPSNEYHVLGTDGFGRSDSRDKLRDHFEVSAYYIVVAALNLLAKLNNINKKVVEEAIIKFNINADKINPRLA

Protein

Pyruvate dehydrogenase E1 component: aceE

Gene

aceE

Protein

Pyruvate dehydrogenase E1 component

Organism

Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)

Length

887 amino acids

Function

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

Mass

101.396 kDa

Sequence

MSENLYNDVDPIETRDWVQAIESVIRREGHKRAHFLIEQVLKTAKINRKEFFRSSFTSDYINTISREDEYEYPGNLILEKRIRSAIRWNAIMMVLRASKKNLELGGHLSSFQSSATIYEVCFNHFFQAKNHKDGGDLVYFQGHISPGIYARSFLEGRLSEEQIDNFRQEVDGIGLSSYPHPKLMPNFWQFPTVSMGLGPLCAIYQAKFLKYLHNRELKNTSKQIVYAFLGDGEMDEPESKGAISIAVREKLDNLIFIINCNLQRLDGPVVGNGKIVNELESFFYGAGWKVIKVIWGSRWDCLLKKDTSGKLIQLMNETVDGDYQTFKSKDGAYVRKYFFGKYKETYDLVKDMTDEEIWKLNRGGHDPKKMFNALKKAKETKYKPTVILAHTVKGYGMGVIAEGKNIAHQIKKININGIIHIRDRFNIPVSNDEINKLPYVTFKKNSEEYCYIHSQRKKLGGYIPFRLSSFTGKLILPKLIDFQSLLEEQKKDISTTVAFIRVLNIILKNNSIKHLIVPIIADEARTFGMEGLFRKIGIYSSSGQKYTPQDREQLAYYKEEKKGQILQEGINELGAASSWLAAATSYSTNDFPMILFYIYYSIFGFQRIGDLFWAAGDQQARGFLIGGTSGRTTLNGEGLQHEDGHSHIQSLTIPNCISYDPAFAYEVAVIIQDGLRRMYGPSQENIYYYITTINENYYMPAMPIGVEEGICKGIYKLKTLHGTTSKVQLIGSGAILRSVCEAAEILLKDYSITTDIYSVTSFTELARNGEDCERWNMLHPNEKNKIAYVKQIMNKNPTVAATDYMKLFAEQIRHYIPSQEYHVLGTDGFGRSDSRDKLRDHFEVNAYYIVIAALNLLANINDIKKKVVEDAIMKFNIDANKINPRLS

Protein

Pyruvate dehydrogenase E1 component: aceE

Gene

aceE

Protein

Pyruvate dehydrogenase E1 component

Organism

Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)

Length

887 amino acids

Function

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

Mass

100.906 kDa

Sequence

MAEFSSNDIDPIETEDWIQAIKSVIREDGLERANFIINTVKKYVPYKNKVVFKKCAISNYVNTIPVEEEPNYPGDLFIEQKIRSVIRWNAIMMVLRASKKNLDLGGHLSSFQSAATIYEVCFNHFFHATNENNGGDLVYFQGHISPGIYSRAFIEDRLTQKQLDNFRQEIDGIGLSSYPHPKLMPNFWQFPTVSMGLGPICAIYQAKFLKYLEHRNLKCTNNQKVYAFLGDGEMDEPESKGAISIAAREKLDNLIFIVNCNLQRLDGPVIGNGKVIDELESVFKGCGWKVIKVIWGSKWDSLLKKDVSGKLIKLMNETLDGDYQTFKSKNGAYIRKYFFGKYLETQELVKDMSDDQIWNLDRGGHDPKKIYAALSKANSIVGKPVIILMHTVKGYGMGDIAEGKNIAHQIKKIDIKGITYIKNRFKVPVEENELKYLPYVSFDANSIEYKYLHARRKKLGGYLPIRLSNFTNFFTLPKLDEFSTLLTEQKKEISTTIVFIRILNILLRNSFIKDRIVPIIADEARTFGMEGLFRKIGIYNFIGQKYTPQDKELLAYYKEDKKGQILQEGINELGAAASWLAAATSYSTNNFPMIPFYIFYSMFGFQRIGDLFWAAGDQQARGFLIGGTSGKTTLNGEGLQHGDGHSHIQALTIPNCISYNPAYAYELAVIVHDGLQRMYGPSQENIYYYITTMNENYVMPGISKNMYEGICKGIYKLKHVGKKNVKVQIMGSGSILQCVCRAAEILLEEYDIGSDVYSVTSFTELARNGQDCDRWNLLHPTQEKKVPFVTKIMNKLPAIAVTDYMKLFSEQVRAYIPAVTYRVLGTDGFGRSDSRKNLRRYFEIDEYHIVIAVLGELEKIGDVDKNTIVNAISKFKIDINKVNPRLA

Protein

Pyruvate dehydrogenase E1 component: aceE

Gene

aceE

Protein

Pyruvate dehydrogenase E1 component

Organism

Escherichia coli O157:H7

Length

887 amino acids

Function

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

Mass

99.668 kDa

Sequence

MSERFPNDVDPIETRDWLQAIESVIREEGVERAQYLIDQLLAEARKGGVNVAAGTGISNYINTIPVEEQPEYPGNLELERRIRSAIRWNAIMTVLRASKKDLELGGHMASFQSSATIYDVCFNHFFRARNEQDGGDLVYFQGHISPGVYARAFLEGRLTQEQLDNFRQEVHGNGLSSYPHPKLMPEFWQFPTVSMGLGPIGAIYQAKFLKYLEHRGLKDTSKQTVYAFLGDGEMDEPESKGAITIATREKLDNLVFVINCNLQRLDGPVTGNGKIINELEGIFEGAGWNVIKVMWGSRWDELLRKDTSGKLIQLMNETVDGDYQTFKSKDGAYVREHFFGKYPETAALVADWTDEQIWALNRGGHDPKKIYAAFKKAQETKGKATVILAHTIKGYGMGDAAEGKNIAHQVKKMNMDGVRHIRDRFNVPVSDADIEKLPYITFPEGSEEHTYLHAQRQKLHGYLPSRQPNFTEKLELPSLQDFGALLEEQSKEISTTIAFVRALNVMLKNKSIKDRLVPIIADEARTFGMEGLFRQIGIYSPNGQQYTPQDREQVAYYKEDEKGQILQEGINELGAGCSWLAAATSYSTNNLPMIPFYIYYSMFGFQRIGDLCWAAGDQQARGFLIGGTSGRTTLNGEGLQHEDGHSHIQSLTIPNCISYDPAYAYEVAVIMHDGLERMYGEKQENVYYYITTLNENYHMPAMPEGAEEGIRKGIYKLETIEGSKGKVQLLGSGSILRHVREAAEILAKDYGVGSDVYSVTSFTELARDGQDCERWNMLHPLETPRVPYIAQVMNDAPAVASTDYMKLFAEQVRTYVPADDYRVLGTDGFGRSDSRENLRHHFEVDASYVVVAALGELAKRGEIDKKVVADAIAKFNIDADKVNPRLA

Protein

Pyruvate dehydrogenase E1 component: aceE

Gene

aceE

Protein

Pyruvate dehydrogenase E1 component

Organism

Escherichia coli (strain K12)

Length

887 amino acids

Function

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

Mass

99.668 kDa

Sequence

Protein

Pyruvate dehydrogenase E1 component: aceE

Gene

aceE

Protein

Pyruvate dehydrogenase E1 component

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Length

886 amino acids

Function

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

Mass

99.131 kDa

Sequence

MSEILKNDVDPIETQDWLQSLDSLIREEGVERAQYIVEQVIGQARTSGVSLPTGVTTDYVNTIPVAEQPAYPGDHAIERRIRSAVRWNAIAMVLRSQKKDLDLGGHISTFQSAATMYEVCYNHFFKAATEKNGGDLIFFQGHAAPGMYARAFLEGRLTEEQMDNFRQEAFTDGLSSYPHPKLMPEFWQFSTVSMGLGPVNAIYQARFLKYLDNRGLKDTKDQKVYAFLGDGEMDEIESKGALTFAAREHLDNLIFTISCNLQRLDGPVNGNGKIVQELEGLFTGAGWEVIKVLWGSDWDKLFAKDTSGKLTQLMMEVVDGDYLTFKSKDGAYIREHFFGRYPETAALVADMTDDEIWALRRGAHDSEKLYAAYAKAQNATKPVVILAHQVKGYKIPEAESKNTAHQSKKMSYESLKGFRDFFELPLTDEQVEKLEYIKFAEGTPEYEYLHGHRKALNGYVPARRTKFDVEYKVPALEEFKALLEEQPRGISTTMAFTRALNILLKDKNIGKTIVPMIADEARTFGMEGLFRQVGIYNPHGQNYIPSDRDLVAYYREAKDGQVLQEGINELGATASWLAAANSYSVNNQPMIPFFIYYSMFGFQRVGDMMWAAGDQLARGFMVGGTSGRTTLNGEGLQHEDGHSHIQAGIIPNCITYDPSFAFEVAVIMQDGINRMYGEKQEDVFYYMTTLNEVMDQPAMPAGAEEGIRKGLYKFETVEGKKGKGHVQLLGSGAIMRHVREAAQILANDYGVTSDVFSAPSFNELAREGHDAARWNLLHPTETQRVPYVAQVLADLPTVASTDYVKGYADQIRAFVPSKHYHVLGTDGFGRSDSRANLREHFEVDARYVVVAALSQLAKEGTVSNQVVADAIAKFGLNVDRINPLYA

Protein

Pyruvate dehydrogenase E1 component: aceE

Gene

aceE

Protein

Pyruvate dehydrogenase E1 component

Organism

Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

Length

882 amino acids

Function

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

Mass

99.564 kDa

Sequence

MQDLDPVETQEWLDALESVLDREGEDRAHYLMTRMGELASRSGTQLPYAITTPYRNTIPVTHEARMPGDLFMERRIRSLVRWNALAMVMRANKHDPDLGGHISTFASSATLYDIGFNYFFQAPTDEHGGDLVFFQGHASPGVYARAFLEGRISEEQLENFRQEVDGNGLSSYPHPWLMPDFWQFPTVSMGLGPIQAIYQARFMKYLESRGFIPAGKQKVWCFMGDGECDEPESLGAISLAGREKLDNLIFVINCNLQRLDGPVRGNAKIIQELEGVFRGAEWNVNKVIWGRFWDPLFAKDTAGLLQQRMDEVIDGEYQNYKAKDGAYVREHFFGARPELLEMVKDLSDEEIWKLNRGGHDPYKVYAAYHQAVNHKGQPTVILAKTIKGYGTGSGEAKNIAHNVKKVDVDSLRAFRDKFDIPVKDADLEKLPFYKPEEGSAEAKYLAERRAALGGFMPVRRQKSMSVPVPPLETLKAMLDGSGDREISTTMAFVRIISQLVKDKELGPRIVPIVPDEARTFGMEGMFRQLGIYSSVGQLYEPVDKDQVMFYREDKKGQILEEGINEAGAMSSWIAAGTSYSTHNQPMLPFYIFYSMFGFQRIGDLAWAAGDSRAHGFLIGGTAGRTTLNGEGLQHEDGHSHLLASTIPNCRTYDPTYAYELAVIIREGSRQMIEEQQDIFYYITVMNENYVQPAMPKGAEEGIIKGMYLLEEDKKEAAHHVQLLGSGTILREVEEAAKLLRNDFGIGADVWSVPSFNELRRDGLAVERWNRLHPGQKPKQSYVEECLGGRRGPVIASTDYMKLYAEQIRQWVPSKEYKVLGTDGFGRSDSRKKLRNFFEVDRHWVVLAALEALADRGDIEPKVVAEAIAKYGIDPEKRNPLDC

Protein

Pyruvate dehydrogenase E1 component: aceE