Protein
2-epi-5-epi-valiolone 7-phosphate 2-epimerase
Organism
Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110)
Function
Involved in the biosynthesis of the alpha-glucosidase inhibitor acarbose. Catalyzes the 2-epimerisation of 2-epi-5-epivaliolone 7-phosphate to yield 5-epi-valiolone 7-phosphate.
Similarity
Belongs to the hyi family.
Sequence
MTCRVGLTEWRLAPSGAAAIRLAAAVGADGIQLDFGGPGRGVLVDGPGRAGQLRAVADEAGVDLLALAGNLLNDIGLTSQPAVVQPVLARLADTATELGVPLLIVPSFRRSAITDAMSFTRTAAALRWAVSLAEARGIVLASENVLPPARARQLVEEVGSPAFRLLLDTFNPVRYGLDPAWLATELRPWWADQIHLKDGPPDTGPSPLLGAGQGGVRRTLTALRGSPAPVRALVLENDYRDGHGARLRADLEWARRAAVNARESEKGKLT